化学化工学院机构知识库

Institutional Repository, College of Chemistry and Chemical Engineering

 

兰州大学机构库  > 化学化工学院  > 期刊论文
题名: PEGylated Oxidized Alginate-DOX Prodrug Conjugate Nanoparticles Cross-Linked with Fluorescent Carbon Dots for Tumor Theranostics
作者: Jia, X; Pei, ML; Zhao, XB; Tian, K; Zhou, TT; Liu, P(刘鹏)
收录类别: SCIE ; BIOSIS
出版日期: 2016-09
刊名: ACS BIOMATERIALS SCIENCE & ENGINEERING
卷号: 2, 期号:9, 页码:1641-1648
英文摘要: Theranostic nanomedicine has recently emerged as an appealing approach for tumor chemotherapy. Here, for the first time, fluorescent carbon dots (Cdots) were used as cross-linker for tumor theranostic nanoparticles. Novel theranostic nanoparticles of approximately 27 nm with a doxorubicin (DOX) content of 0.2532 mg/mg (mPEG-OAL-DOX/Cdots) were designed by conjugating DOX onto mPEG-OAL/Cdots nanoparticles that were prepared by cross-linking the PEGylated oxidized alginate (mPEG-OAL) with Cdots. Due to the acid-labile Schiff base conjugating linkage, the theranostic prodrug nanoparticles showed low levels of DOX release in the simulated physiological media, which indicated premature drug leakage could be reduced during body circulation. Interestingly, the in vitro DOX release was triggered in the simulated tumor microenvironment without burst release. MTT assay and CLSM analysis showed that the mPEG-OAL/Cdots nanoparticles were noncytotoxic, but that the mPEG-OAL-DOX/Cdots theranostic nanoparticles exhibited high degrees of inhibition of cancer cells due to their nucleus-targeting DOX delivery. In addition, their cellular fluorescence characteristic demonstrated a potential application for imaging-guided drug delivery in tumor treatment.
关键词: tumor theranostics ; prodrug nanoparticle ; carbon dots ; oxidized alginate ; imaging-guided drug delivery
作者部门: [Liu, Peng] Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China ; Lanzhou Univ, Coll Chem & Chem Engn, Key Lab Nonferrous Met Chem & Resources Utilizat, Lanzhou 730000, Peoples R China
通讯作者: Liu, P (reprint author), Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China.
学科分类: Materials Science
文章类型: Article
所属项目编号: National Natural Science Foundation of China [20904017] ; Program for New Century Excellent Talents in University [NCET-09-0441]
所属项目名称: 国家自然科学基金项目 ; 新世纪优秀人才支持计划
项目资助者: NSFC ; MOE
语种: 英语
DOI: 10.1021/acsbiomaterials.6b00443
ISSN号: 2373-9878
WOS记录号: WOS:000383220000022
BIOSIS记录号: BCI:BCI201600791357
IR记录号: WOS:000383220000022
第一机构:
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.lzu.edu.cn/handle/262010/180562
Appears in Collections:化学化工学院_期刊论文

Files in This Item:

There are no files associated with this item.


Recommended Citation:
Jia, X,Pei, ML,Zhao, XB,et al. PEGylated Oxidized Alginate-DOX Prodrug Conjugate Nanoparticles Cross-Linked with Fluorescent Carbon Dots for Tumor Theranostics[J]. ACS BIOMATERIALS SCIENCE & ENGINEERING,2016,2(9):1641-1648.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Altmetrics Score
 
Google Scholar
Similar articles in Google Scholar
[Jia, X]'s Articles
[Pei, ML]'s Articles
[Zhao, XB]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Jia, X]‘s Articles
[Pei, ML]‘s Articles
[Zhao, XB]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Email:
Passwd
验 证:
换一张
Have you forgotten your password? Log In
Copyright © 2007-2017  兰州大学 - Feedback
Powered by CSpace