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兰州大学机构库  > 化学化工学院  > 期刊论文
题名: Self-fluorescent and stimuli-responsive mesoporous silica nanoparticles using a double-role curcumin gatekeeper for drug delivery
作者: Xu, XB; Lu, SY; Gao, CM; Feng, C; Wu, C; Bai, X; Gao, NN; Wang, ZY; Liu, MZ(柳明珠)
收录类别: SCIE ; EI ; BIOSIS
出版日期: 2016-09-15
刊名: CHEMICAL ENGINEERING JOURNAL
卷号: 300, 页码:185-192
英文摘要: Self-fluorescent and stimuli-responsive drug nanocarriers were developed based on curcumin gatekeeper on a platform of mesoporous silica nanoparticles with large pores (named LP) for drug delivery. The cur cumin gatekeeper was anchored to the surface of LP via thiol-ene "click" chemistry, and the pluronic polymer, F127, was coated to the out surface of the nanocarrier by self-assembly through hydrophobic interactions to provide a hydrophobic micro-environment and to improve the dispersity of the nanoparticles. In vitro drug release profiles indicated that curcumin can be confined in the pores in absence of GSH at pH 7.4. In the presence of GSH and at pH 5.5 condition, the beta-thioesters were hydrolyzed leading to curcumin release. Further investigations show that the curcumin gatekeeper can be served as fluorescent agent to avoid the use of other fluorescent label. This novel drug nanocarriers will inspire the development of new smart and self-fluorescent drug nanocarriers with imaging and therapeutic goals for cancer therapy. (C) 2016 Elsevier B.V. All rights reserved.
关键词: Cancer ; Drug delivery ; Mesoporous materials ; Curcumin ; Self-fluorescence
作者部门: [Xu, Xiubin ; Lu, Shaoyu ; Gao, Chunmei ; Feng, Chen ; Wu, Can ; Bai, Xiao ; Gao, Nannan ; Wang, Zhiyong ; Liu, Mingzhu] Lanzhou Univ, Dept Chem, State Key Lab Appl Organ Chem, Key Lab Nonferrous Met Chem & Resources Utilizat, Lanzhou 730000, Peoples R China
通讯作者: Lu, SY ; Liu, MZ (reprint author), Lanzhou Univ, Dept Chem, State Key Lab Appl Organ Chem, Key Lab Nonferrous Met Chem & Resources Utilizat, Lanzhou 730000, Peoples R China.
学科分类: Engineering
文章类型: Article
所属项目编号: National Natural Science Foundation of China [51541304, 51273086] ; Fund for Fostering Talents from National Natural Science Foundation of China [J1103307] ; Special Doctorial Program Fund from the Ministry of Education of China [20130211110017] ; Fundamental Research Funds for the Central Universities [lzujbky-2015-198, lzujbky-2015-26]
所属项目名称: 国家自然科学基金项目 ; 国家基础科学人才培养基金项目 ; 高等学校博士学科点专项科研基金 ; 中央高校基本科研业务费专项资金
项目资助者: NSFC ; MOE ; LZU
语种: 英语
DOI: 10.1016/j.cej.2016.04.087
ISSN号: 1385-8947
WOS记录号: WOS:000378181400019
EI记录号: 20161902350749
BIOSIS记录号: BCI:BCI201600668778
IR记录号: WOS:000378181400019
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内容类型: 期刊论文
URI标识: http://ir.lzu.edu.cn/handle/262010/180577
Appears in Collections:化学化工学院_期刊论文

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Recommended Citation:
Xu, XB,Lu, SY,Gao, CM,et al. Self-fluorescent and stimuli-responsive mesoporous silica nanoparticles using a double-role curcumin gatekeeper for drug delivery[J]. CHEMICAL ENGINEERING JOURNAL,2016,300:185-192.
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