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兰州大学机构库  > 化学化工学院  > 期刊论文
题名: Redox-responsive core-cross-linked mPEGylated starch micelles as nanocarriers for intracellular anticancer drug release
作者: Wu, Can; Yang, Jinlong; Xu, Xiubin; Gao, Chunmei; Lü, Shaoyu; Liu, MZ(柳明珠)
收录类别: SCIE ; EI
出版日期: 2016-10-01
刊名: European Polymer Journal
卷号: 83, 页码:230-243
出版者: ELSEVIER
出版地: OXFORD
英文摘要: Novel redox-responsive core-cross-linked polymers were prepared by cross-linking mPEGylated starch (mPEG-St) with 3,3'-dithiodipropionic acid (DPA), a cross-linker containing a disulfide bond. The structure of the polymer based on starch (mPEG-St-DPA) was characterized using nuclear magnetic resonance (NMR), Fourier transform infrared spectroscopy (FTIR), and Raman spectroscopy. In addition, these polymers could self assemble into micelles in phosphate-buffered saline (PBS) solution. The size and critical micelle concentration (CMC) of the mPEG-St-DPA micelles decreased with an increase in the degree of cross-linking. Interestingly, the size of the mPEG-St-DPA micelles increased gradually in the presence of 10 mM glutathione (GSH) owing to the cleavage of the disulfide bonds in the micellar core. The mPEG-St-DPA micelles showed good stability, exhibiting slight changes in size after 1000-fold dilution with PBS solution or 10-fold dilution with dimethyl formamide (DMF). The results of a protein adsorption test indicated that the mPEG-St-DPA micelles were hemocompatible. Doxorubicin (DOX), a model anticancer drug, was efficiently loaded into the mPEG-St-DPA micelles. The in vitro release studies revealed that the DOX-loaded mPEG-St-DPA micelles showed enhanced release of DOX in the presence of GSH. An in vitro MIT assay confirmed that the core-cross-linked mPEG-St-DPA micelles were biocompatible with HeLa cells, and the DOX-loaded mPEGSt-DPA micelles displayed higher inhibition of HeLa cell proliferation. These results suggest that the redox-responsive mPEG-St-DPA micelles hold great potential as ideal drug delivery carriers for cancer therapy. (C) 2016 Elsevier Ltd. All rights reserved.
关键词: Starch ; Polymeric micelles ; Redox-responsive ; Drug delivery
作者部门: (1) Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, State Key Laboratory of Applied Organic Chemistry and Department of Chemistry, Lanzhou University, Lanzhou ; 730000, China
通讯作者: Gao, CM ; Liu, MZ (reprint author), Lanzhou Univ, State Key Lab Appl Organ Chem, Key Lab Nonferrous Met Chem & Resources Utilizat, Lanzhou 730000, Peoples R China.
学科分类: Polymer Science
文章类型: Article
所属项目编号: National Natural Science Foundation of China [51273086] ; Ministry of Education of China [20130211110017] ; Fundamental Research Funds for the Central Universities [lzujbky-2015-198, lzujbky-2015-26]
所属项目名称: 国家自然科学基金项目 ; 高等学校博士学科点专项科研基金 ; 中央高校基本科研业务费专项资金
项目资助者: NSFC ; MOE ; LZU
语种: 英语
DOI: 10.1016/j.eurpolymj.2016.08.018
ISSN号: 0014-3057
WOS记录号: WOS:000385595300020
EI记录号: 20163502756078
IR记录号: 20163502756078
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内容类型: 期刊论文
URI标识: http://ir.lzu.edu.cn/handle/262010/180588
Appears in Collections:化学化工学院_期刊论文

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Recommended Citation:
Wu, Can,Yang, Jinlong,Xu, Xiubin,et al. Redox-responsive core-cross-linked mPEGylated starch micelles as nanocarriers for intracellular anticancer drug release[J]. European Polymer Journal,2016,83:230-243.
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