化学化工学院机构知识库

Institutional Repository, College of Chemistry and Chemical Engineering

 

兰州大学机构库  > 化学化工学院  > 期刊论文
题名: Multi-functionalized hyaluronic acid nanogels crosslinked with carbon dots as dual receptor-mediated targeting tumor theranostics
作者: Jia, X; Han, Y; Pei, ML; Zhao, XB; Tian, K; Zhou, TT; Liu, P(刘鹏)
收录类别: SCIE ; EI ; MEDLINE ; BIOSIS
出版日期: 2016-11-05
刊名: CARBOHYDRATE POLYMERS
卷号: 152, 页码:391-397
英文摘要: Hyaluronic acid (HA)-based theranostic nanogels were designed for the tumor diagnosis and chemotherapy, by crosslinking the folate-terminated poly(ethylene glycol) modified hyaluronic acid (FA-PEG-HA) with carbon dots (CDs) for the first time. Due to the extraordinary fluorescence property of the integrated CDs, the theranostic nanogels could be used for the real-time and noninvasive location tracking to cancer cells. HA could load Doxorubicin (DOX) via electrostatic interaction with a drug-loading capacity (DLC) of 32.5%. The nanogels possessed an ideal release of DOX in the weak acid environment, while it was restrained in the neutral media, demonstrating the pH-responsive controlled release behavior. The cytotoxicity and cellular uptake results clearly illustrated that most DOX was released and accumulated in the cell nuclei and killed the cancer cells efficaciously, due to their dual receptor-mediated targeting characteristics. (C) 2016 Elsevier Ltd. All rights reserved.
关键词: Tumor theranostics ; Hyaluronic acid ; Carbon dots ; Dual receptor-mediated targeting ; Tumor microenvironment-responsive controlled release
作者部门: [Liu, Peng] Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China ; Lanzhou Univ, Coll Chem & Chem Engn, Key Lab Nonferrous Met Chem & Resources Utilizat, Lanzhou 730000, Peoples R China
通讯作者: Liu, P (reprint author), Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China.
学科分类: Chemistry; Polymer Science
文章类型: Article
所属项目编号: National Natural Science Foundation of China [20904017] ; Program for New Century Excellent Talents in University of the Ministry of Education of China [NCET-09-0441]
所属项目名称: 国家自然科学基金项目 ; 新世纪优秀人才支持计划
项目资助者: NSFC ; MOE
语种: 英语
DOI: 10.1016/j.carbpol.2016.06.109
ISSN号: 0144-8617
WOS记录号: WOS:000380944500044
EI记录号: 20162902623888
PM记录号: 27516286
BIOSIS记录号: BCI:BCI201600707943
IR记录号: WOS:000380944500044
第一机构:
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.lzu.edu.cn/handle/262010/180595
Appears in Collections:化学化工学院_期刊论文

Files in This Item:

There are no files associated with this item.


Recommended Citation:
Jia, X,Han, Y,Pei, ML,et al. Multi-functionalized hyaluronic acid nanogels crosslinked with carbon dots as dual receptor-mediated targeting tumor theranostics[J]. CARBOHYDRATE POLYMERS,2016,152:391-397.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Altmetrics Score
 
Google Scholar
Similar articles in Google Scholar
[Jia, X]'s Articles
[Han, Y]'s Articles
[Pei, ML]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Jia, X]‘s Articles
[Han, Y]‘s Articles
[Pei, ML]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Email:
Passwd
验 证:
换一张
Have you forgotten your password? Log In
Copyright © 2007-2017  兰州大学 - Feedback
Powered by CSpace