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兰州大学机构库  > 化学化工学院  > 期刊论文
题名: A fluorescence enhancement probe based on BODIPY for the discrimination of cysteine from homocysteine and glutathione
作者: Gong, DY; Tian, YJ; Yang, CD; Iqbal, A; Wang, ZP; Liu, WS(刘伟生); Qin, WW; Zhu, XT; Guo, HC
收录类别: SCIE ; EI ; MEDLINE ; BIOSIS
出版日期: 2016-11-15
刊名: BIOSENSORS & BIOELECTRONICS
卷号: 85, 页码:178-183
英文摘要: Herein, a fluorescent probe BODIPY-based glyoxal hydrazone (BODIPY-GH) (1) for cysteine based on inhibiting of intramolecular charge transfer (ICT) quenching process upon reaction with the unsaturated aldehyde has been synthesized, which exhibits longer excitation wavelength, selective and sensitive colorimetric and fluorimetric response toward cysteine in natural media. The probe shows highly selectivity towards cysteine over homocysteine and glutathione as well as other amino acids with a significant fluorescence enhancement response within 15 min In the presence of 50 equiv. of homocysteine, the emission increased slightly within 15 min and completed in 2.5 h to reach its maximum intensity. Therefore, the discrimination of cysteine from homocysteine and glutathione can be achieved through detection of probe 1. It shows low cytotoxicity and excellent membrane permeability toward living cells, which was successfully applied to detect and image intracellular cysteine effectively by confocal fluorescence imaging. (C) 2016 Elsevier B.V. All rights reserved.
关键词: BODIPY ; Fluorescent probes ; Living cells ; Cysteine ; Bioimaging
作者部门: [Gong, Deyan ; Yang, Chengduan ; Iqbal, Anam ; Liu, Weisheng ; Qin, Wenwu] Lanzhou Univ, Key Lab Nonferrous Met Chem & Resources Utilizat, Coll Chem & Chem Engn, Lanzhou 730000, Peoples R China ; [Gong, Deyan ; Yang, Chengduan ; Iqbal, Anam ; Liu, Weisheng ; Qin, Wenwu] Lanzhou Univ, State Key Lab Appl Organ Chem, Coll Chem & Chem Engn, Lanzhou 730000, Peoples R China ; [Tian, Yuejun ; Wang, Zhiping] Lanzhou Univ, Hosp 2, Inst Urol, Lanzhou, Gansu, Peoples R China ; [Zhu, Xiangtao ; Guo, Huichen] Chinese Acad Agr Sci, Lanzhou Vet Res Inst, Minist Agr, State Key Lab Vet Etiol Biol, Xujiaping 1, Lanzhou 730046, Gansu, Peoples R China ; [Zhu, Xiangtao ; Guo, Huichen] Chinese Acad Agr Sci, Lanzhou Vet Res Inst, Minist Agr, Key Lab Anim Virol, Xujiaping 1, Lanzhou 730046, Gansu, Peoples R China
通讯作者: Qin, WW (reprint author), Lanzhou Univ, Key Lab Nonferrous Met Chem & Resources Utilizat, Coll Chem & Chem Engn, Lanzhou 730000, Peoples R China. ; Qin, WW (reprint author), Lanzhou Univ, State Key Lab Appl Organ Chem, Coll Chem & Chem Engn, Lanzhou 730000, Peoples R China. ; Guo, HC (reprint author), Chinese Acad Agr Sci, Lanzhou Vet Res Inst, Minist Agr, State Key Lab Vet Etiol Biol, Xujiaping 1, Lanzhou 730046, Gansu, Peoples R China. ; Guo, HC (reprint author), Chinese Acad Agr Sci, Lanzhou Vet Res Inst, Minist Agr, Key Lab Anim Virol, Xujiaping 1, Lanzhou 730046, Gansu, Peoples R China.
学科分类: Biophysics; Biotechnology & Applied Microbiology; Chemistry; Electrochemistry; Science & Technology - Other Topics
文章类型: Article
所属项目编号: National Natural Science Foundation of China [21271094, 81372733/H1619] ; National Science Foundation of China for Fostering Talents in Basic Research of the National Natural Science Foundation of China [J1103307] ; Ministry of Science and Technology of China [2014DFA31890]
所属项目名称: 国家自然科学基金项目 ; 国家基础科学人才培养基金项目 ; 国家国际科技合作专项
项目资助者: NSFC ; MOST
语种: 英语
DOI: 10.1016/j.bios.2016.05.013
ISSN号: 0956-5663
WOS记录号: WOS:000382410100023
EI记录号: 20161902372111
PM记录号: 27176916
BIOSIS记录号: BCI:BCI201600759743
IR记录号: WOS:000382410100023
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内容类型: 期刊论文
URI标识: http://ir.lzu.edu.cn/handle/262010/180598
Appears in Collections:化学化工学院_期刊论文

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Recommended Citation:
Gong, DY,Tian, YJ,Yang, CD,et al. A fluorescence enhancement probe based on BODIPY for the discrimination of cysteine from homocysteine and glutathione[J]. BIOSENSORS & BIOELECTRONICS,2016,85:178-183.
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