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题名: Study on glutathione's inhibition to dopamine polymerization and its application in dopamine determination in alkaline environment based on silver selenide/molybdenum selenide/glassy carbon electrode
作者: Xia, Xiaohong; Shen, Xuan; Du, Yonglin; Ye, Weichun; Wang, CM(王春明)
收录类别: SCIE ; EI
出版日期: 2016-12-01
刊名: SENSORS AND ACTUATORS B-CHEMICAL
卷号: 237, 页码:685-692
出版者: ELSEVIER
出版地: LAUSANNE
英文摘要: Cellular glutathione plays critical roles in protecting neuronal cells against dopamine induced oxidative stress and electrophilic cellular damage; inspired by above mentioned properties of glutathione, we used glutathione as a polymerization inhibitor to develop a dopamine biosensor which can be used in alkaline environment. The detection of dopamine in alkaline environment has been challenged by its polymerization for many years, glutathione as a kind of thiol can be used to prevent the polymerization of dopamine in alkaline environment by eliminating the electrophilic quinone molecules needed during the polymerization. In order to enhance the electrochemical performance of electrode, Ag2Se/MoSe2 composite with large exposed surface areas was synthesized, which improved the sensitivity and stability for dopamine detection. The low oxidation peak potential for dopamine, 0.04 V vs. SCE, indicats that glutathione can realize the electrooxidation of dopamine at lower potential in alkaline environment. In this study, by introducing glutathione to inhibit the dopamine polymerization, sensitive and stable detection of dopamine can be achieved at pH 8.5 based on the Ag2Se/MoSe2/GCE. (C) 2016 Elsevier B.V. All rights reserved.
关键词: Glutathione ; Polymerization inhibitor ; Silver/molybdenum selenide ; Dopamine sensor ; Alkaline environment
作者部门: (1) School of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou ; 730000, China
通讯作者: Wang, CM (reprint author), Lanzhou Univ, Sch Chem & Chem Engn, Lanzhou 730000, Peoples R China.
学科分类: Chemistry; Electrochemistry; Instruments & Instrumentation
文章类型: Article
所属项目编号: National Science Foundation of China [51372106, J1103307]
所属项目名称: 国家自然科学基金项目 ; 国家基础科学人才培养基金项目
项目资助者: NSFC
语种: 英语
DOI: 10.1016/j.snb.2016.06.154
ISSN号: 0925-4005
WOS记录号: WOS:000384010500083
EI记录号: 20164102897392
IR记录号: 20164102897392
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内容类型: 期刊论文
URI标识: http://ir.lzu.edu.cn/handle/262010/180607
Appears in Collections:化学化工学院_期刊论文

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Recommended Citation:
Xia, Xiaohong,Shen, Xuan,Du, Yonglin,et al. Study on glutathione's inhibition to dopamine polymerization and its application in dopamine determination in alkaline environment based on silver selenide/molybdenum selenide/glassy carbon electrode[J]. Sensors and Actuators, B: Chemical,2016,237:685-692.
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