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题名: A pH/glutathione double responsive drug delivery system using molecular imprint technique for drug loading
作者: Zhang, Kelin; Guan, Xiujuan; Qiu, Yanxin; Wang, Dongdong; Zhang, Xiaoyu; Zhang, HX(张海霞)
收录类别: SCIE ; EI
出版日期: 2016-12-15
刊名: Applied Surface Science
卷号: 389, 页码:1208-1213
出版者: ELSEVIER
出版地: AMSTERDAM
英文摘要: A surface molecular imprinting polymer (SMIP) with doxorubicin (DOX) as the template was prepared on the surface of mesoporous silica nanoparticles (MSNs), which were further used as DOX carriers. The loading amount of DOX was calculated as 10.5 +/- 0.2 wt% with loading efficiency of 70 +/- 8%. The DOX release was controlled because the monomer molecule used in polymerization of SMIP containing sulfur sulfur bonding, which could be decomposed with an acidic pH and glutathione (GSH). Under an acidic pH and high concentration of GSH, there was greater release of DOX than under normal physiological conditions, which induced less damage to normal cells than to cancer cells. Confocal laser scanning microscopy studies verified the invasion of the DOX within SMIP into TCA8113 cancer cells. These results indicate that the prepared SMIP was an effective nanocarrier. (C) 2016 Elsevier B.V. All rights reserved.
关键词: Molecular imprint polymer ; Nanocarrier ; Control release
作者部门: (1) College of Chemistry and Chemical Engineering, Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, Lanzhou University, Lanzhou ; 730000, China ; (2) Institute of Physiology, School of Basic Medical Sciences, Lanzhou University, Lanzhou ; 730000, China
通讯作者: Zhang, HX (reprint author), Lanzhou Univ, Key Lab Nonferrous Met Chem & Resources Utilizati, Coll Chem & Chem Engn, Lanzhou 730000, Peoples R China.
学科分类: Chemistry; Materials Science; Physics
文章类型: Article
所属项目编号: National Science Foundation of China [21575055, 21375052]
所属项目名称: 国家自然科学基金项目
项目资助者: NSFC
语种: 英语
DOI: 10.1016/j.apsusc.2016.08.107
ISSN号: 0169-4332
WOS记录号: WOS:000384577600148
EI记录号: 20163502753831
IR记录号: 20163502753831
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内容类型: 期刊论文
URI标识: http://ir.lzu.edu.cn/handle/262010/180609
Appears in Collections:化学化工学院_期刊论文

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Recommended Citation:
Zhang, Kelin,Guan, Xiujuan,Qiu, Yanxin,et al. A pH/glutathione double responsive drug delivery system using molecular imprint technique for drug loading[J]. Applied Surface Science,2016,389:1208-1213.
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