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题名: Identification of resveratrol derivative 3,3 ',4,4 ',5,5 '-hexamethoxy-trans-stilbene as a novel pro-angiogenic small-molecule compound
作者: Chen, ZQ; Zhang, L; Yu, JT; Chen, LK; Zhou, B(周波)
收录类别: SCIE ; PubMed ; MEDLINE
出版日期: 2016-11-15
刊名: EUROPEAN JOURNAL OF PHARMACOLOGY
卷号: 791, 页码:185-194
出版者: ELSEVIER
出版地: AMSTERDAM
英文摘要: The potential to promote neovascularization in ischemic tissues using exogenous agents is an attractive avenue for therapeutics. To identify novel pro-angiogenic small-molecule compound, we screened a series of resveratrol methylated derivatives and identified 3,3',4,4', 5,5'-hexamethoxy-trans-stilbene (3,3',4,4',5,5'-HMS) potently promotes proliferation, migration, invasion and tube formation of human umbilical vein VECs (HUVECs) in vitro. Furthermore, 3,3',4,4',5,5'-HMS accelerates neo-vessels sprouting of rat aortic rings ex vivo, and neovascularization of chick chorioallantoic membrane (CAM) and mouse matrigel plugs in vivo. Microarray analyses show that the level of early growth response 1 (EGR-1), an inducible pro-angiogenic gene regulatory factor, was upregulated. The upregulation of EGR-1 was confirmed by semiquantitative RT-PCR, quantitative real-time PCR and western blotting analyses. In addition, the levels of several pro-angiogenic factors including transforming growth factor beta 1 (TGF-beta 1), vascular endothelial growth factor (VEGF), nitric oxide (NO), and the activity of endothelial NO synthase (eNOS) were elevated in 3,3',4,4',5,5'-HMS-treated HUVECs. Inhibition of NO synthase by L-NAME blocked the pro-angiogenic effects of 3,3',4,4',5,5'-HMS. Our research shows that 3,3',4,4',5,5'-HMS dramatically promoted angiogenesis in vitro, ex vivo and in vivo, which might represent a novel potential agent for the development of therapeutic drugs to treat ischemic diseases. (C) 2016 Elsevier B.V. All rights reserved.
关键词: 3,3 ',4,4 ',5,5 '-hexamethoxy-trans-stilbene ; Angiogenesis ; Early growth response-1 ; Vascular endothelial cell
作者部门: [Chen, ZhiQiang ; Zhang, Lu ; Yu, JingTing ; Chen, LiangKe] Henan Univ Technol, Coll Bioengn, Lianhua St, Zhengzhou 450001, Peoples R China ; [Zhou, Bo] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China
通讯作者: Zhang, L (reprint author), Henan Univ Technol, Coll Bioengn, Lianhua St, Zhengzhou 450001, Peoples R China.
学科分类: Pharmacology & Pharmacy
文章类型: Article
所属项目编号: National Natural Science Foundation of China [31471296, 21372109] ; Program for Science and Technology Innovation Talents in Universities of Henan Province [15HASTIT031] ; Scientific Research Special Funds of Provincial Colleges and Universities [2015RCJH04] ; Key Project of Henan Educational Committee [14A180028] ; Foundation for University Key Teacher by Henan Educational Committee [2013GGJS-078]
所属项目名称: 国家自然科学基金项目
项目资助者: NSFC
语种: 英语
DOI: 10.1016/j.ejphar.2016.08.034
ISSN号: 0014-2999
WOS记录号: WOS:000388827700020
PM记录号: 27590357
IR记录号: WOS:000388827700020
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内容类型: 期刊论文
URI标识: http://ir.lzu.edu.cn/handle/262010/188866
Appears in Collections:化学化工学院_期刊论文

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Recommended Citation:
Chen, ZQ,Zhang, L,Yu, JT,et al. Identification of resveratrol derivative 3,3 ',4,4 ',5,5 '-hexamethoxy-trans-stilbene as a novel pro-angiogenic small-molecule compound[J]. EUROPEAN JOURNAL OF PHARMACOLOGY,2016,791:185-194.
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