兰州大学机构库 >化学化工学院
Identification of resveratrol derivative 3,3 ',4,4 ',5,5 '-hexamethoxy-trans-stilbene as a novel pro-angiogenic small-molecule compound
Chen, ZQ; Zhang, L; Yu, JT; Chen, LK; Zhou, B(周波); Zhang, L (reprint author), Henan Univ Technol, Coll Bioengn, Lianhua St, Zhengzhou 450001, Peoples R China.
收录类别SCIE ; PubMed ; MEDLINE
2016-11-15
发表期刊EUROPEAN JOURNAL OF PHARMACOLOGY
卷号791页码:185-194
出版者ELSEVIER
出版地AMSTERDAM
摘要The potential to promote neovascularization in ischemic tissues using exogenous agents is an attractive avenue for therapeutics. To identify novel pro-angiogenic small-molecule compound, we screened a series of resveratrol methylated derivatives and identified 3,3',4,4', 5,5'-hexamethoxy-trans-stilbene (3,3',4,4',5,5'-HMS) potently promotes proliferation, migration, invasion and tube formation of human umbilical vein VECs (HUVECs) in vitro. Furthermore, 3,3',4,4',5,5'-HMS accelerates neo-vessels sprouting of rat aortic rings ex vivo, and neovascularization of chick chorioallantoic membrane (CAM) and mouse matrigel plugs in vivo. Microarray analyses show that the level of early growth response 1 (EGR-1), an inducible pro-angiogenic gene regulatory factor, was upregulated. The upregulation of EGR-1 was confirmed by semiquantitative RT-PCR, quantitative real-time PCR and western blotting analyses. In addition, the levels of several pro-angiogenic factors including transforming growth factor beta 1 (TGF-beta 1), vascular endothelial growth factor (VEGF), nitric oxide (NO), and the activity of endothelial NO synthase (eNOS) were elevated in 3,3',4,4',5,5'-HMS-treated HUVECs. Inhibition of NO synthase by L-NAME blocked the pro-angiogenic effects of 3,3',4,4',5,5'-HMS. Our research shows that 3,3',4,4',5,5'-HMS dramatically promoted angiogenesis in vitro, ex vivo and in vivo, which might represent a novel potential agent for the development of therapeutic drugs to treat ischemic diseases. (C) 2016 Elsevier B.V. All rights reserved.
关键词3,3 ',4,4 ',5,5 '-hexamethoxy-trans-stilbene Angiogenesis Early growth response-1 Vascular endothelial cell
作者部门[Chen, ZhiQiang;
Zhang, Lu;
Yu, JingTing;
Chen, LiangKe] Henan Univ Technol, Coll Bioengn, Lianhua St, Zhengzhou 450001, Peoples R China;
[Zhou, Bo] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China
学科领域Pharmacology & Pharmacy
所属项目编号National Natural Science Foundation of China [31471296, 21372109] ; Program for Science and Technology Innovation Talents in Universities of Henan Province [15HASTIT031] ; Scientific Research Special Funds of Provincial Colleges and Universities [2015RCJH04] ; Key Project of Henan Educational Committee [14A180028] ; Foundation for University Key Teacher by Henan Educational Committee [2013GGJS-078]
资助项目国家自然科学基金项目
项目资助者NSFC
DOI10.1016/j.ejphar.2016.08.034
ISSN0014-2999
文章类型Article
语种英语
WOS记录号WOS:000388827700020
PM记录号27590357
IR记录号WOS:000388827700020
第一机构
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文献类型期刊论文
条目标识符http://ir.lzu.edu.cn/handle/262010/188866
Collection化学化工学院
通讯作者Zhang, L (reprint author), Henan Univ Technol, Coll Bioengn, Lianhua St, Zhengzhou 450001, Peoples R China.
Recommended Citation:
GB/T 7714
Chen, ZQ,Zhang, L,Yu, JT,et al. Identification of resveratrol derivative 3,3 ',4,4 ',5,5 '-hexamethoxy-trans-stilbene as a novel pro-angiogenic small-molecule compound[J]. EUROPEAN JOURNAL OF PHARMACOLOGY,2016,791:185-194.
APA Chen, ZQ,Zhang, L,Yu, JT,Chen, LK,Zhou, B,&Zhang, L .(2016).Identification of resveratrol derivative 3,3 ',4,4 ',5,5 '-hexamethoxy-trans-stilbene as a novel pro-angiogenic small-molecule compound.EUROPEAN JOURNAL OF PHARMACOLOGY,791,185-194.
MLA Chen, ZQ,et al."Identification of resveratrol derivative 3,3 ',4,4 ',5,5 '-hexamethoxy-trans-stilbene as a novel pro-angiogenic small-molecule compound".EUROPEAN JOURNAL OF PHARMACOLOGY 791(2016):185-194.
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