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题名: Versatile rare-earth oxide nanocomposites: enhanced chemo/photothermal/photodynamic anticancer therapy and multimodal imaging
作者: Shen, TT; Zhang, Y; Kirillov, AM; Hu, BB; Shan, CF; Liu, WS; Tang, Y
收录类别: SCIE
出版日期: 2016-12-28
刊名: JOURNAL OF MATERIALS CHEMISTRY B
卷号: 4, 期号:2-17, 页码:7832-7844
出版者: ROYAL SOC CHEMISTRY
出版地: CAMBRIDGE
英文摘要: The development of novel nanocomposites that combine multiple imaging and therapeutic strategies has recently attracted considerable attention because of their cumulative and synergistic therapeutic effects. In this study, doxorubicin (DOX)- and indocyanine green (ICG)-loaded Gd2O3:Eu3+@P(NIPAm-co-MAA)@THA@cRGD nanocomposites {abbreviated as DOX-ICG-TPNPs@cRGD; P(NIPAm-co-MAA): poly[(N-isopropylacrylamide)-co-(methacrylic acid)); THA: 4,4-trifluoro-1-(9-pentylcarbazole-3-yl)-1,3-butanedione; cRGD: cyclic(Arg-Gly-Asp-D-Phe-Lys)} were designed, assembled, fully characterized, and successfully applied in multimodal imaging diagnosis and therapy. The designed nanocomposites display a versatile, multifunctional platform that includes (a) simultaneous targeting with cRGD, (b) multimodal imaging, including two-photon luminescence (TPL), magnetic resonance imaging (MRI), computed tomography (CT), and photothermal imaging (PTI), and (c) stimuli-responsive coordinated drug delivery; this results in a highly efficient synergistic chemo/photothermal/photodynamic anticancer therapy (chemo/PTT/PDT). An important feature of the obtained nanocomposites is the enhancement of both the PTT and PDT effects of ICG due to the effective light protection of a two-photon sensitized Eu3+ complex. This integrated strategy shows an excellent synergistic inhibition of tumor growth triggered by NIR laser irradiation, as confirmed by both in vitro and in vivo tests. The present study emphasizes the influence and interaction of every component in the nanocomposites and demonstrates that the systematic design of nanocarriers can lead to an assembly of smart nanomaterials with enhanced antitumor efficacy.
作者部门: [Shen, Tingting ; Zhang, Yu ; Hu, Binbin ; Shan, Changfu ; Liu, Weisheng ; Tang, Yu] Lanzhou Univ, Coll Chem & Chem Engn, Key Lab Nonferrous Met Chem & Resources Utilizat, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China ; [Kirillov, Alexander M.] Univ Lisbon, Inst Super Tecn, Ctr Quim Estrutural, Complexo 1,Av Rovisco Pais, P-1049001 Lisbon, Portugal
通讯作者: Tang, Y (reprint author), Lanzhou Univ, Coll Chem & Chem Engn, Key Lab Nonferrous Met Chem & Resources Utilizat, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China.
学科分类: Materials Science
文章类型: Article
所属项目编号: National Natural Science Foundation of China [21471071, 21431002]
所属项目名称: 国家自然科学基金项目
项目资助者: NSFC
语种: 英语
DOI: 10.1039/c6tb02244h
ISSN号: 2050-750X
WOS记录号: WOS:000391778200006
IR记录号: WOS:000391778200006
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内容类型: 期刊论文
URI标识: http://ir.lzu.edu.cn/handle/262010/188930
Appears in Collections:化学化工学院_期刊论文

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Recommended Citation:
Shen, TT,Zhang, Y,Kirillov, AM,et al. Versatile rare-earth oxide nanocomposites: enhanced chemo/photothermal/photodynamic anticancer therapy and multimodal imaging[J]. JOURNAL OF MATERIALS CHEMISTRY B,2016,4(2-17):7832-7844.
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