兰州大学机构库 >化学化工学院
Versatile rare-earth oxide nanocomposites: enhanced chemo/photothermal/photodynamic anticancer therapy and multimodal imaging
Shen, TT; Zhang, Y; Kirillov, AM; Hu, BB; Shan, CF; Liu, WS(刘伟生); Tang, Y; Tang, Y (reprint author), Lanzhou Univ, Coll Chem & Chem Engn, Key Lab Nonferrous Met Chem & Resources Utilizat, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China.
2016-12-28
发表期刊JOURNAL OF MATERIALS CHEMISTRY B
ISSN2050-750X
卷号4期号:2-17页码:7832-7844
出版者ROYAL SOC CHEMISTRY
摘要The development of novel nanocomposites that combine multiple imaging and therapeutic strategies has recently attracted considerable attention because of their cumulative and synergistic therapeutic effects. In this study, doxorubicin (DOX)- and indocyanine green (ICG)-loaded Gd2O3:Eu3+@P(NIPAm-co-MAA)@THA@cRGD nanocomposites {abbreviated as DOX-ICG-TPNPs@cRGD; P(NIPAm-co-MAA): poly[(N-isopropylacrylamide)-co-(methacrylic acid)); THA: 4,4-trifluoro-1-(9-pentylcarbazole-3-yl)-1,3-butanedione; cRGD: cyclic(Arg-Gly-Asp-D-Phe-Lys)} were designed, assembled, fully characterized, and successfully applied in multimodal imaging diagnosis and therapy. The designed nanocomposites display a versatile, multifunctional platform that includes (a) simultaneous targeting with cRGD, (b) multimodal imaging, including two-photon luminescence (TPL), magnetic resonance imaging (MRI), computed tomography (CT), and photothermal imaging (PTI), and (c) stimuli-responsive coordinated drug delivery; this results in a highly efficient synergistic chemo/photothermal/photodynamic anticancer therapy (chemo/PTT/PDT). An important feature of the obtained nanocomposites is the enhancement of both the PTT and PDT effects of ICG due to the effective light protection of a two-photon sensitized Eu3+ complex. This integrated strategy shows an excellent synergistic inhibition of tumor growth triggered by NIR laser irradiation, as confirmed by both in vitro and in vivo tests. The present study emphasizes the influence and interaction of every component in the nanocomposites and demonstrates that the systematic design of nanocarriers can lead to an assembly of smart nanomaterials with enhanced antitumor efficacy.
出版地CAMBRIDGE
学科领域Materials Science
作者部门[Shen, Tingting;
Zhang, Yu;
Hu, Binbin;
Shan, Changfu;
Liu, Weisheng;
Tang, Yu] Lanzhou Univ, Coll Chem & Chem Engn, Key Lab Nonferrous Met Chem & Resources Utilizat, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China;
[Kirillov, Alexander M.] Univ Lisbon, Inst Super Tecn, Ctr Quim Estrutural, Complexo 1,Av Rovisco Pais, P-1049001 Lisbon, Portugal
DOI10.1039/c6tb02244h
文章类型Article
收录类别SCIE
所属项目编号National Natural Science Foundation of China [21471071, 21431002]
语种英语
资助项目国家自然科学基金项目
项目资助者NSFC
WOS记录号WOS:000391778200006
IR记录号WOS:000391778200006
第一机构
Citation statistics
???java.ItemTag.Counts???10[WOS]   ???java.ItemTag.WOS.Record???     ???java.ItemTag.WOS.Related-Records???
文献类型期刊论文
条目标识符http://ir.lzu.edu.cn/handle/262010/188930
Collection化学化工学院
通讯作者Tang, Y (reprint author), Lanzhou Univ, Coll Chem & Chem Engn, Key Lab Nonferrous Met Chem & Resources Utilizat, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China.
Recommended Citation:
GB/T 7714
Shen, TT,Zhang, Y,Kirillov, AM,et al. Versatile rare-earth oxide nanocomposites: enhanced chemo/photothermal/photodynamic anticancer therapy and multimodal imaging[J]. JOURNAL OF MATERIALS CHEMISTRY B,2016,4(2-17):7832-7844.
APA Shen, TT.,Zhang, Y.,Kirillov, AM.,Hu, BB.,Shan, CF.,...&Tang, Y .(2016).Versatile rare-earth oxide nanocomposites: enhanced chemo/photothermal/photodynamic anticancer therapy and multimodal imaging.JOURNAL OF MATERIALS CHEMISTRY B,4(2-17),7832-7844.
MLA Shen, TT,et al."Versatile rare-earth oxide nanocomposites: enhanced chemo/photothermal/photodynamic anticancer therapy and multimodal imaging".JOURNAL OF MATERIALS CHEMISTRY B 4.2-17(2016):7832-7844.
Files in This Item:
There are no files associated with this item.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Altmetrics Score
谷歌学术
谷歌学术Similar articles in Google Scholar
[Shen, TT]'s Articles
[Zhang, Y]'s Articles
[Kirillov, AM]'s Articles
百度学术
百度学术Similar articles in Google Scholar
[Shen, TT]'s Articles
[Zhang, Y]'s Articles
[Kirillov, AM]'s Articles
必应学术
必应学术Similar articles in Google Scholar
[Shen, TT]'s Articles
[Zhang, Y]'s Articles
[Kirillov, AM]'s Articles
Related Copyright Policies
Null
???item.sidebar.baidu.bookmark-share???
???jsp.display-item.all??? (0)
[???jsp.display-item.idea???]
???jsp.display-item.comment-text2???
Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.