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兰州大学机构库  > 化学化工学院  > 期刊论文
题名: Design of Block Copolymer Micellar Aggregates for Co-Delivery of Enzyme and Anticancer Prodrug
作者: Li, HP; Chen, LL; Shi, YT; Yuan, BB; Ma, YX; Wei, H; Zhao, GH
收录类别: SCIE ; PubMed
出版日期: 2017-01
刊名: CHEMISTRY-AN ASIAN JOURNAL
卷号: 12, 期号:1-2, 页码:176-180
出版者: WILEY
出版地: WEINHEIM
英文摘要: Traditional enzyme-prodrug therapy (EPT) is a two-step strategy, which has many serious deficiencies, so having a one-step EPT treatment becomes a problem of immediate interest. This study aims to achieve an effective co-delivery of horseradish peroxidase (HRP) as a kind of enzyme for prodrug activation and ethyl 3-indoleacetate (EIA) as anticancer prodrug. A ternary block copolymer PEG-PAsp(AED)-CA consisting of poly(ethylene glycol) (PEG), reduction-sensitive poly (N-(2,2-dithiobis(ethylamine)) aspartamide) PAsp(AED), and cholic acid (CA) was synthesized and assembled into spherical micelles which encapsulated EIA in its hydrophobic core and HRP in a reduction-sensitive interlayer. TEM photographs show that the polymer micelle is around 40nm, and the cell survival rate test shows that the EIA/HRP polymer micelle is highly lethal to human lung adenocarcinoma cells. Thus, co-delivery of EIA and HRP demonstrates great potential in cancer therapy, offering a structurally simple and highly tunable platform for the synchronous delivery of enzymes and prodrugs in EPT.
关键词: drug delivery ; enzymes ; horseradish peroxidase ; micelles ; reactive oxygen species
作者部门: [Li, Hongping ; Chen, Lulu ; Shi, Yuting ; Yuan, Binbin ; Wei, Hua ; Zhao, Guanghui] Lanzhou Univ, Key Lab Nonferrous Met Chem & Resources Utilizat, Inst Biochem Engn & Environm Technol, State Key Lab Appl Organ Chem,Coll Chem & Chem En, Lanzhou 730000, Peoples R China ; [Ma, Yingxia] Lanzhou Univ Technol, Sch Mat Sci & Engn, Lanzhou 730050, Peoples R China ; [Zhao, Guanghui] Lanzhou Univ, Zhongwei High Tech Inst, Zhongwei 755000, Peoples R China
通讯作者: Zhao, GH (reprint author), Lanzhou Univ, Key Lab Nonferrous Met Chem & Resources Utilizat, Inst Biochem Engn & Environm Technol, State Key Lab Appl Organ Chem,Coll Chem & Chem En, Lanzhou 730000, Peoples R China. ; Zhao, GH (reprint author), Lanzhou Univ, Zhongwei High Tech Inst, Zhongwei 755000, Peoples R China.
学科分类: Chemistry
文章类型: Article
所属项目编号: National Natural Science Foundation of China [21301081] ; Natural Science Foundation of Gansu Province [1506RJYA221] ; Fundamental Research Funds for the Central Universities [lzujbky-2015-30, lzujbky-2016-ct05]
所属项目名称: 国家自然科学基金项目 ; 中央高校基本科研业务费专项资金 ; 甘肃省青年科技基金计划
项目资助者: NSFC ; LZU ; GSSTD
语种: 英语
DOI: 10.1002/asia.201601198
ISSN号: 1861-4728
WOS记录号: WOS:000393434200001
PM记录号: 27966832
IR记录号: WOS:000393434200001
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内容类型: 期刊论文
URI标识: http://ir.lzu.edu.cn/handle/262010/188999
Appears in Collections:化学化工学院_期刊论文

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Recommended Citation:
Li, HP,Chen, LL,Shi, YT,et al. Design of Block Copolymer Micellar Aggregates for Co-Delivery of Enzyme and Anticancer Prodrug[J]. CHEMISTRY-AN ASIAN JOURNAL,2017,12(1-2):176-180.
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