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题名: ASSOCIATION OF MTHFR A1298C POLYMORPHISM WITH BREAST CANCER AND/OR OVARIAN CANCER RISK: AN UPDATED META-ANALYSIS
作者: Liu, W; Li, Y; Li, R; Han, X; Ma, Y; Liu, B; Kong, XZ
收录类别: SCIE
出版日期: 2016
刊名: AFRICAN JOURNAL OF TRADITIONAL COMPLEMENTARY AND ALTERNATIVE MEDICINES
卷号: 13, 期号:1-5, 页码:72-86
出版者: AFRICAN NETWORKS ETHNOMEDICINES
出版地: ILE-IFE
英文摘要: Background: Recent years have witnessed the discovery of similar gene variations between breast cancer and ovarian cancer, inherited breast and ovarian cancer in particular. A large number of case-control studies have been conducted to explore the association of Methylenetetrahydrofolate Reductase (MTHFR) A1298C polymorphism with breast cancer and/or ovarian cancer risk. However, the results are still inconsistent and inconclusive. Consequently, we performed a meta-analysis to evaluate the association between MTHFR A1298C polymorphism and breast, ovarian cancer risk. Materials and Methods: A comprehensive retrieval was conducted in the electronic database of PubMed, Web of Science and Chinese National Knowledge Infrastructure (CNKI) until June 2015 to identify eligible studies. A total of 35 studies which examined the association of MTHFR A1298C polymorphism with breast cancer and/or ovarian cancer were identified. The pooled odds ratios (ORs) with 95 % confidence intervals (CIs) were used to assess the effect of gene polymorphism. And allele model, homozygous model, co-dominant model, dominant model, recessive model were applied. Result: In the overall analysis, significantly increased breast cancer and/or ovarian cancer risk was found (for allele model A VS C OR = 1.05, CI: 1.02-1.08, P = 4x10(-3); for homozygous model AA VS CC OR = 1.11, CI: 1.03-1.19, P = 5x10(-3); for recessive model (AC + AA) VS CC: OR = 1.10, CI: 1.03-1.18, P = 7x10(-3)). Conclusion: In the subgroup analysis, significantly increased breast cancer risk was identified among Caucasians. MTHFR A1298C polymorphism might contribute to an increased risk of breast cancer and/or ovarian cancer susceptibility. In addition, MTHFR A1298C polymorphism had a significant association with breast cancer in Caucasians.
关键词: Breast cancer ; Ovarian cancer ; MTHFR A1298C ; Polymorphism ; Meta-analysis
作者部门: [Liu, Wei ; Liu, Bin] Lanzhou Univ, Sch Hosp Stomatol, Sch Nucl Sci & Technol, Lanzhou 730000, Gansu, Peoples R China ; [Li, Yi ; Ma, Ying] Lanzhou Univ, Sch Basic Med Sci, Lanzhou 730000, Gansu, Peoples R China ; [Li, Rui] Lanzhou Univ, Sch Stomatol, Lanzhou 730000, Gansu, Peoples R China ; [Han, Xiao] Gansu Univ Tradit Chinese Med, Lanzhou 730000, Gansu, Peoples R China ; [Kong, Xiangzhen] Qinghai Univ, Affiliated Hosp, Res Dept, Xining 810000, Qinghai Provinc, Peoples R China
学科分类: Integrative & Complementary Medicine
文章类型: Article
语种: 英语
DOI: 10.21010/ajtcam.v13i5.11
ISSN号: 0189-6016
WOS记录号: WOS:000392618200011
IR记录号: WOS:000392618200011
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内容类型: 期刊论文
URI标识: http://ir.lzu.edu.cn/handle/262010/189086
Appears in Collections:口腔医学院_期刊论文

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Recommended Citation:
Liu, W,Li, Y,Li, R,et al. ASSOCIATION OF MTHFR A1298C POLYMORPHISM WITH BREAST CANCER AND/OR OVARIAN CANCER RISK: AN UPDATED META-ANALYSIS[J]. AFRICAN JOURNAL OF TRADITIONAL COMPLEMENTARY AND ALTERNATIVE MEDICINES,2016,13(1-5):72-86.
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