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题名: Effects of Ru(CO)3Cl-glycinate on the developmental toxicities induced by X-ray and carbon-ion irradiation in zebrafish embryos
作者: Zhou, R; Song, JE; Si, J; Zhang, H; Liu, B; Gan, L; Zhou, X; Wang, YP; Yan, JF; Zhang, QJ
收录类别: SCIE ; PubMed ; MEDLINE
出版日期: 2016-11
刊名: MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
卷号: 793, 页码:41-50
出版者: ELSEVIER
出版地: AMSTERDAM
英文摘要: The inhibitory effects of carbon monoxide (CO), generated by Ru(CO)(3)Cl-glycinate [CO-releasing molecule (CORM-3)], on developmental toxicity in zebrafish embryos induced by ionizing radiation with different linear energy transfer (LET) were studied. Zebrafish embryos at 5 h post-fertilization were irradiated with X-ray (low-LET) and carbon-ion (high-LET) with or without pretreatment of CORM-3 1 h before irradiation. CORM-3 pre-treatment showed a significant inhibitory effect on X-ray irradiation-induced developmental toxicity, but had little effect on carbon-ion irradiation-induced developmental toxicity. X-ray irradiation-induced significant increase in ROS levels and cell apoptosis could be modified by CORM-3 pretreatment. However, embryos exposed to carbon-ion irradiation showed significantly increase of cell apoptosis without obvious ROS generation, which could not be attenuated by CORM-3 pretreatment. CORM-3 could inhibit apoptosis induced by ionizing radiation with low-LET as an effective ROS scavenger. The expression of pro-apoptotic genes increased significantly after X-ray irradiation, but increased expression was reduced markedly when CORM-3 was applied before irradiation. Moreover, the protein levels of P53 and,gamma-H2AX increased markedly after X-ray irradiation, which could be modified by the presence of CORM-3. The protective effect of CORM-3 on X-ray irradiation occurred mainly by suppressing ROS generation and DNA damage, and thus inhibiting the activation of P53 and the mitochondria) apoptotic pathway, leading to the attenuation of cell apoptosis and consequently alleviating X-ray irradiation-induced developmental toxicity at lethal and sub-lethal levels. (C) 2016 Elsevier B.V. All rights reserved.
关键词: CORM-3 ; Zebrafish embryos ; X-ray irradiation ; Carbon-ion irradiation ; Oxidative stress ; Apoptosis
作者部门: [Zhou, Rong ; Si, Jing ; Zhang, Hong ; Gan, Lu ; Zhou, Xin ; Wang, Yupei ; Yan, Junfang ; Zhang, Qianjing] Chinese Acad Sci, Inst Modern Phys, Dept Radiat Med, Lanzhou 730000, Gansu, Peoples R China ; [Zhou, Rong ; Si, Jing ; Zhang, Hong ; Gan, Lu ; Zhou, Xin ; Wang, Yupei ; Yan, Junfang ; Zhang, Qianjing] Chinese Acad Sci, Key Lab Heavy Ion Radiat Biol & Med, Lanzhou 730000, Peoples R China ; [Zhou, Rong ; Si, Jing ; Zhang, Hong ; Gan, Lu ; Zhou, Xin ; Wang, Yupei ; Yan, Junfang ; Zhang, Qianjing] Key Lab Basic Res Heavy Ion Radiat Applicat Med, Lanzhou 730000, Gansu, Peoples R China ; [Wang, Yupei ; Yan, Junfang ; Zhang, Qianjing] Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China ; [Song, Jing'e ; Liu, Bin] Lanzhou Univ, Sch Hosp Stomatol, Lanzhou 730000, Peoples R China
通讯作者: Zhang, H (reprint author), Chinese Acad Sci, Inst Modern Phys, Dept Radiat Med, Lanzhou 730000, Gansu, Peoples R China.
学科分类: Biotechnology & Applied Microbiology; Genetics & Heredity; Toxicology
文章类型: Article
所属项目编号: Key Program of National Natural Science Foundation of China [U1432248] ; National Key Projects of Research and Development [2016YFC0904600] ; National Natural Science Foundation of China [11305226, 11605255] ; Western Talent Program of Chinese Academy of Sciences [2013-165, Y460030XB0] ; Scientific Technology Research Projects of Lanzhou City [2015-3-75, Y660040SJ0]
所属项目名称: 国家自然科学基金项目 ; 国家重点研发计划 ; 兰州市科技局资助项目
项目资助者: NSFC ; MOST ; LZSTB
语种: 英语
DOI: 10.1016/j.mrfmmm.2016.11.001
ISSN号: 0027-5107
WOS记录号: WOS:000390739600005
PM记录号: 27837686
IR记录号: WOS:000390739600005
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内容类型: 期刊论文
URI标识: http://ir.lzu.edu.cn/handle/262010/189089
Appears in Collections:口腔医学院_期刊论文

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Recommended Citation:
Zhou, R,Song, JE,Si, J,et al. Effects of Ru(CO)3Cl-glycinate on the developmental toxicities induced by X-ray and carbon-ion irradiation in zebrafish embryos[J]. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS,2016,793:41-50.
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