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题名: Fe-56 irradiation-induced cognitive deficits through oxidative stress in mice
作者: Yan, JW; Liu, Y; Zhao, QY; Li, J; Mao, AH; Li, HY; Di, CX; Zhang, H
收录类别: SCIE
出版日期: 2016
刊名: TOXICOLOGY RESEARCH
卷号: 5, 期号:1-6, 页码:1672-1679
出版者: ROYAL SOC CHEMISTRY
出版地: CAMBRIDGE
英文摘要: The rapid growth of manned space flight results in more concerns about health risks and an urgent need for health assessment for space travel. The cosmic environment is complicated and full of radiation. Because of their strong biological effects, heavy ions such as Fe-56 ions are considered to be an important component of these lethal galactic rays. Due to the importance of brain function to astronauts, we explored the long-term effects and potential mechanisms of Fe-56 ion radiation on mice brains containing the hippocampus. In our study, radiation doses were carried out with 0.5 Gy, 1 Gy or 2 Gy. One month after whole-body Fe-56 ion exposure, the Morris water maze test was performed to assess the ability of spatial learning and memory. A histological study was used for pathology analysis of the hippocampus. Alteration of oxidative stress was reflected by MDA and GSH and oxidative DNA damage marked by 8-OHdG was detected by biochemical and immunofluorescence methods. In our results, irradiated groups exhibited significant changes in behavioral performance and also showed loose and edematous arrangement in the pathological characteristics. Furthermore, whole brain levels of MDA, GSH and 8-OHdG increased in the irradiated groups. In addition, increased expression of 8-OHdG can also be detected by immunofluorescence in the hippocampus. Our findings revealed a linkage between radiation-induced oxidative stress and behavioral deficits. This may suggest an underlying mechanism of brain tissue protection and risk assessment in manned space flight.
作者部门: [Yan, Jiawei ; Liu, Yang ; Zhao, Qiuyue ; Mao, Aihong ; Li, Hongyan ; Di, Cuixia ; Zhang, Hong] Chinese Acad Sci, Inst Modern Phys, Lanzhou 730000, Peoples R China ; [Yan, Jiawei ; Liu, Yang ; Zhao, Qiuyue ; Mao, Aihong ; Li, Hongyan ; Di, Cuixia ; Zhang, Hong] Chinese Acad Sci, Key Lab Heavy Ion Radiat Med, Lanzhou 730000, Peoples R China ; [Yan, Jiawei ; Liu, Yang ; Zhao, Qiuyue ; Mao, Aihong ; Li, Hongyan ; Di, Cuixia ; Zhang, Hong] Key Lab Heavy Ion Radiat Med Gansu Prov, Lanzhou 730000, Peoples R China ; [Yan, Jiawei ; Zhao, Qiuyue ; Mao, Aihong] Univ Chinese Acad Sci, Beijing 100039, Peoples R China ; [Li, Jie] Lanzhou Univ, Sch Stomatol, Lanzhou 730000, Peoples R China ; [Mao, Aihong] Inst Gansu Med Sci Res, Lanzhou 730050, Peoples R China
通讯作者: Zhang, H (reprint author), Chinese Acad Sci, Inst Modern Phys, Lanzhou 730000, Peoples R China. ; Zhang, H (reprint author), Chinese Acad Sci, Key Lab Heavy Ion Radiat Med, Lanzhou 730000, Peoples R China. ; Zhang, H (reprint author), Key Lab Heavy Ion Radiat Med Gansu Prov, Lanzhou 730000, Peoples R China.
学科分类: Toxicology
文章类型: Article
所属项目编号: Key Program of National Natural Science Foundation of China [U1432248] ; National Key Projects of Research and Development [2016YFC0904600] ; National Natural Science Foundation of China [11305224, 11675234] ; Western Talent Program of Chinese Academy of Sciences [Y260230XB0]
所属项目名称: 国家自然科学基金项目 ; 国家重点研发计划
项目资助者: NSFC ; MOST
语种: 英语
DOI: 10.1039/c6tx00282j
ISSN号: 2045-452X
WOS记录号: WOS:000387013300017
IR记录号: WOS:000387013300017
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内容类型: 期刊论文
URI标识: http://ir.lzu.edu.cn/handle/262010/189090
Appears in Collections:口腔医学院_期刊论文

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Recommended Citation:
Yan, JW,Liu, Y,Zhao, QY,et al. Fe-56 irradiation-induced cognitive deficits through oxidative stress in mice[J]. TOXICOLOGY RESEARCH,2016,5(1-6):1672-1679.
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