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题名: Overexpression of stathmin promotes metastasis and growth of malignant solid tumors: a systemic review and meta-analysis
作者: Rong, BX; Liu, H; Gao, WL; Yang, SY
收录类别: SCIE
出版日期: 2016-11-29
刊名: ONCOTARGET
卷号: 7, 期号:2-17, 页码:78980-78993
出版者: IMPACT JOURNALS LLC
出版地: ALBANY
英文摘要: Stathmin has been investigated to be involved in development and progress of malignant tumors. This study was to clarify the relationship between expression of stathmin and tumors and assess its clinical significance. We identified 25 studies with a total of 3,571 individuals from the electronic bibliographic databases and strictly evaluated the quality and heterogeneity of included studies. We analysed the relationship between expression of stathmin and clinical characteristics by the fixedeffects and random-effects of meta-analysis and constructed a summary receiveroperator characteristic curve to estimate the test characteristics. The results showed that patients with cancer displayed a higher stathmin expression than those of noncancer individuals (OR, 0.31), and overexpression of stathmin correlated with tumor cell differentiation (OR, 0.73), lymph node invasion (OR, 0.80) and high TNM stage (OR, 0.67). The pooled sensitivity of stathmin for distinguishing malignant tumors was 0.73 and the specificity was 0.77. The maximum balance joint for sensitivity and specificity (the Q-value) was 0.7566 and the area under the curve (AUC) was 0.8234. In conclusion, these results showed that overexpression of stathmin intimately correlated with malignant behavior of tumors, suggesting it could be a risk factor of malignant tumors. Stathmin had great sensitivity and specificity indicated it should be a significant molecular biomarker for malignant tumors.
关键词: stathmin ; tumors ; immunohistochemistry ; meta-analysis ; diagnosis
作者部门: [Rong Biaoxue] Xian Med Univ, Affiliated Hosp 1, Dept Resp Med, Xian, Peoples R China ; [Liu Hua] Gansu Prov Hosp, Dept Resp Med, Lanzhou, Peoples R China ; [Gao Wenlong] Lanzhou Univ, Dept Stat & Epidemiol, Coll Med, Lanzhou, Peoples R China ; [Yang Shuanying] Xi An Jiao Tong Univ, Affiliated Hosp 2, Dept Resp Med, Xian, Peoples R China
通讯作者: Rong, BX (reprint author), Xian Med Univ, Affiliated Hosp 1, Dept Resp Med, Xian, Peoples R China.
学科分类: Oncology; Cell Biology
文章类型: Article
所属项目编号: Technology Research and Development Plan of Gansu Province [0912TCYA016]
所属项目名称: 甘肃省技术研究与开发专项计划
项目资助者: GSSTD
语种: 英语
DOI: 10.18632/oncotarget.12982
ISSN号: 1949-2553
WOS记录号: WOS:000389636000065
IR记录号: WOS:000389636000065
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内容类型: 期刊论文
URI标识: http://ir.lzu.edu.cn/handle/262010/189119
Appears in Collections:公共卫生学院_期刊论文

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Recommended Citation:
Rong, BX,Liu, H,Gao, WL,et al. Overexpression of stathmin promotes metastasis and growth of malignant solid tumors: a systemic review and meta-analysis[J]. ONCOTARGET,2016,7(2-17):78980-78993.
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