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题名: Evaluation of efficacy and safety for recombinant human adenovirus-p53 in the control of the malignant pleural effusions via thoracic perfusion
作者: Rong, BX; Pan, H; Gao, WL; Yang, SY
收录类别: SCIE
出版日期: 2016-12-15
刊名: SCIENTIFIC REPORTS
卷号: 6
出版者: NATURE PUBLISHING GROUP
出版地: LONDON
英文摘要: A certain number of studies have showed that p53 gene transfer has an anti-tumor activity in vitro and in vivo. This study was to evaluate the efficacy and safety of thoracic perfusion of recombinant human adenovirus p53 (rAd-p53, Gendicine) for controlling malignant pleural effusion (MPE). We searched for the relevant studies from the database of MEDLINE, Web of Science, EMBASE, Cochrance Library and CNKI to collect the trials concerning the efficacy and safety of rAd-p53 to treat MPE. Fourteen randomised controlled trials (RCTs) with 879 patients were involved in this analysis. The rAd-p53 combined with chemotherapeutic agents significantly improved the overall response rate (ORR) (P < 0.001; odds ratio = 3.73) and disease control rate (DCR) (P < 0.001; odds ratio = 2.32) of patients with MPE as well as the quality of life (QOL) of patients (P < 0.001; odds ratio = 4.27), compared with that of chemotherapeutic agents alone. In addition, the participation of rAd-p53 did not have an obvious impact on the most of incidence of adverse reactions (AEs) (P < 0.05) except the fever (P < 0.001). However, the fever was self-limited and could be tolerated well. The application of rAd-p53 through thoracic perfusion for treating MPE had a better efficacy and safety, which could be a potential choice for controlling MPE.
作者部门: [Rong Biaoxue] Xian Med Univ, Affiliated Hosp 1, Dept Resp Med, Xian, Peoples R China ; [Rong Biaoxue] Res Ctr Prevent & Treatment Resp Dis, Xian 710077, Shaanxi Provinc, Peoples R China ; [Pan Hui] Gansu Prov Hosp, Dept Resp Med, Lanzhou, Peoples R China ; [Gao Wenlong] Lanzhou Univ, Inst Epidemiol & Hlth Stat, Sch Publ Hlth, Lanzhou, Peoples R China ; [Yang Shuanying] Xi An Jiao Tong Univ, Affiliated Hosp 2, Dept Resp Med, Xian, Peoples R China
通讯作者: Rong, BX (reprint author), Xian Med Univ, Affiliated Hosp 1, Dept Resp Med, Xian, Peoples R China. ; Rong, BX (reprint author), Res Ctr Prevent & Treatment Resp Dis, Xian 710077, Shaanxi Provinc, Peoples R China.
学科分类: Science & Technology - Other Topics
文章类型: Article
语种: 英语
DOI: 10.1038/srep39355
ISSN号: 2045-2322
WOS记录号: WOS:000390280800001
IR记录号: WOS:000390280800001
第一机构:
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内容类型: 期刊论文
URI标识: http://ir.lzu.edu.cn/handle/262010/189121
Appears in Collections:公共卫生学院_期刊论文

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Recommended Citation:
Rong, BX,Pan, H,Gao, WL,et al. Evaluation of efficacy and safety for recombinant human adenovirus-p53 in the control of the malignant pleural effusions via thoracic perfusion[J]. SCIENTIFIC REPORTS,2016,6.
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