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题名: Increased level of annexin A1 in bronchoalveolar lavage fluid as a potential diagnostic indicator for lung cancer
作者: Rong, BX; Cai, XG; Liu, H; Fu, T; Gao, WL
收录类别: SCIE
出版日期: 2017-01
刊名: INTERNATIONAL JOURNAL OF BIOLOGICAL MARKERS
卷号: 32, 期号:1-1, 页码:E132-E140
出版者: WICHTIG PUBLISHING
出版地: MILAN
英文摘要: Background: Annexin A1 has been implicated in various tumor types, but few studies have investigated its involvement in lung cancer. The purpose of this investigation was to quantify the annexin A1 level in bronchoalveolar lavage fluid (BALF) and analyze its usefulness in lung cancer diagnosis. Methods: Annexin A1 expression was measured by immunohistochemistry and enzyme immunoassay. The sensitivity and specificity of annexin A1 for distinguishing lung cancer were determined by receiver operator characteristic (ROC) curves. Results: Tumor tissues, BALF and serum of patients with lung cancer contained higher levels of annexin A1 than those of the control group of patients with benign lung diseases. Moreover, an increased level of BALF annexin A1 was closely correlated with lymphatic invasion and malignant progression of lung cancer. The sensitivity and specificity of BALF annexin A1 for distinguishing lung cancer were 94.2% and 90.2%, respectively. Conclusions: Increased annexin A1 in BALF was correlated with lymphatic invasion and malignant progression of lung cancer, suggesting that it could be an indicator for discerning lung cancer and predicting outcome.
关键词: Annexin A1 ; Bronchoalveolar lavage fluid ; BALF ; Diagnosis ; Lung cancer
作者部门: [Rong Biaoxue] Xian Med Univ, Affiliated Hosp 1, Dept Resp Med, 48 Fenghao West Rd, Xian 710077, Peoples R China ; [Rong Biaoxue] Res Ctr Prevent & Treatment Resp Med, Xian, Peoples R China ; [Cai Xiguang ; Liu Hua] Gansu Prov Hosp, Dept Resp Med, Lanzhou, Peoples R China ; [Fu Tian] Jining Med Univ, Affiliated Hosp, Dept Resp Med, Jining, Peoples R China ; [Gao Wenlong] Lanzhou Univ, Coll Med, Dept Stat & Epidemiol, Lanzhou, Peoples R China
通讯作者: Rong, BX (reprint author), Xian Med Univ, Affiliated Hosp 1, Dept Resp Med, 48 Fenghao West Rd, Xian 710077, Peoples R China.
学科分类: Biotechnology & Applied Microbiology; Oncology
文章类型: Article
所属项目编号: Technology Research and Development Plan of Gansu Province, China [0912TCYA016]
所属项目名称: 甘肃省技术研究与开发专项计划
项目资助者: GSSTD
语种: 英语
DOI: 10.5301/jbm.5000243
ISSN号: 0393-6155
WOS记录号: WOS:000395937900014
IR记录号: WOS:000395937900014
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内容类型: 期刊论文
URI标识: http://ir.lzu.edu.cn/handle/262010/189125
Appears in Collections:公共卫生学院_期刊论文

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Recommended Citation:
Rong, BX,Cai, XG,Liu, H,et al. Increased level of annexin A1 in bronchoalveolar lavage fluid as a potential diagnostic indicator for lung cancer[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MARKERS,2017,32(1-1):E132-E140.
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