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题名: Effects of human opiorphin on food intake and water intake in mice following central administration
作者: Chen, Y; Tian, XZ; Bai, L; Liu, ZQ; Xiao, XP; Liu, P; Li, XK
收录类别: SCIE ; PubMed
出版日期: 2017-02-22
刊名: NEUROSCIENCE LETTERS
卷号: 641, 页码:62-69
出版者: ELSEVIER
出版地: CLARE
英文摘要: Human opiorphin plays an important pharmacological functions in rats or mice. The present study was performed to investigate effects and underlying mechanism of central injected opiorphin on food intake and water intake in mice. Intracerebroventricularly (i.c.v.) administered opiorphin (5-20 mu g/kg) dose dependently suppressed food intake in fasted mice, but had no influence on food intake in freely feeding mice. The cumulative food intake was significantly decreased at 60 min after injection of 10 and 20 mu g/kg opiorphin and the food intake was significantly reduced during the 20-60 min period after treatment. Non-selected opiate receptor antagonist naloxone could fully block the inhibitory effect induced by opiorphin on cumulative food intake at 60 min in fasted mice, suggesting that the anorexic effect of opiorphin was related to the opioid system. Moreover, the anorexic effect induced by opiorphin in fasted mice was also significantly inhibited by pretreatment with captopril or valsartan, which suggested that endogenous angiotensin may be involved in the response to opiorphin. Interestingly, the effect of opiorphin on water intake was increased in both fasted and freely feeding mice, which was completely blocked by captopril and valsartan. Furthermore, naloxone did not modify the effect of opiorphin on water intake. All together, the food and water intake effects of opiorphin may be due to the protection of the endogenous angiotensin and opioid peptides from degradation by NEP or APN. (C) 2017 Elsevier B.V. All rights reserved.
关键词: Human opiorphin ; Food intake ; Water intake ; Anorexic effect ; Renin-angiotensin system
作者部门: [Chen, Yong ; Tian, Xiao-Zhu ; Bai, Lu ; Liu, Ze-Qi ; Xiao, Xing-Peng ; Liu, Pu ; Li, Xiang-Kai] Lanzhou Univ, Sch Life Sci, Inst Microbiol, 222 Tian Shui South Rd, Lanzhou 730000, Peoples R China
通讯作者: Li, XK (reprint author), Lanzhou Univ, Sch Life Sci, Inst Microbiol, 222 Tian Shui South Rd, Lanzhou 730000, Peoples R China.
学科分类: Neurosciences & Neurology
文章类型: Article
所属项目编号: National Natural Science Foundation of China [31400430] ; Scientific Technology Research Projects of Gansu Province [1104NKCA092]
所属项目名称: 国家自然科学基金项目 ; 甘肃省科技支撑计划
项目资助者: NSFC ; GSSTD
语种: 英语
DOI: 10.1016/j.neulet.2017.01.028
ISSN号: 0304-3940
WOS记录号: WOS:000394918600011
PM记录号: 28104434
IR记录号: WOS:000394918600011
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内容类型: 期刊论文
URI标识: http://ir.lzu.edu.cn/handle/262010/189421
Appears in Collections:生命科学学院_期刊论文

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Recommended Citation:
Chen, Y,Tian, XZ,Bai, L,et al. Effects of human opiorphin on food intake and water intake in mice following central administration[J]. NEUROSCIENCE LETTERS,2017,641:62-69.
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