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题名: Reversible recovery of neuronal structures depends on the degree of neuronal damage after global cerebral ischemia in mice
作者: Zhu, LR; Wang, L; Ju, FR; Khan, A; Cheng, XF; Zhang, SX
收录类别: SCIE ; MEDLINE
出版日期: 2017-03
刊名: EXPERIMENTAL NEUROLOGY
卷号: 289, 页码:1-8
出版者: ELSEVIER
出版地: SAN DIEGO
英文摘要: It has been observed by in vivo imaging that damaged neuronal structures can be reversibly restored after ischemic insults with the application of timely therapeutic interventions. However, what degree of neuronal damage can be restored and the time frame for reversible recovery of neuronal structures remain unclear. Here, transcranial two-photon imaging, histological staining and electron microscopy were used to investigate the reversible recovery of neuronal structures from dendrites to soma after different durations of global cerebral ischemia in mice. Intravital imaging revealed that the damage to dendritic structures was reversible when ischemia time was <1 h, but they became difficult to restore after >3 h of ischemia. Data from fixed YFP brain slice and Golgi staining indicated that the damage of dendritic structures progressively extended to deeper dendritic shafts with the extension of ischemia time. Furthermore, longer duration of ischemia caused an increasing number of degenerating neurons. Importantly, significant chromatin margination and karyopyknosis of neuron were observed after 6 h of ischemia. These data suggested that neuronal structures could be reversibly restored when ischemia time was <1 h, but irreversible and progressive damage to neurons occurred with longer duration of ischemia. Consistently, behavioral performance of post-ischemic animals experienced an ischemia time-dependent recovery. Taken together, our data suggested that recovery of neuronal structures following ischemia was dependent on the duration of ischemia, and prevention of neuronal loss is a key target for therapeutic interventions in ischemic stroke. (C) 2016 Elsevier Inc. All rights reserved.
关键词: Global cerebral ischemia ; Reperfusion ; Neuronal structures ; Recovery ; Two-photon imaging
作者部门: [Zhu, Lirui ; Wang, Lei ; Ju, Furong ; Khan, Akbar ; Cheng, Xiaofeng ; Zhang, Shengxiang] Lanzhou Univ, Sch Life Sci, Gansu Key Lab Biomonitoring & Bioremediat Environ, Lanzhou 730000, Peoples R China
通讯作者: Zhang, SX (reprint author), Lanzhou Univ, Sch Life Sci, 222 South Tianshui Rd, Lanzhou 730000, Gansu, Peoples R China.
学科分类: Neurosciences & Neurology
文章类型: Article
所属项目编号: National Natural Science Foundation of China [81171174, 31471045] ; Specialized Research Fund for the Doctoral Program of Higher Education [SRFDP: 20130211110002]
所属项目名称: 国家自然科学基金项目 ; 高等学校博士学科点专项科研基金
项目资助者: NSFC ; MOE
语种: 英语
DOI: 10.1016/j.expneurol.2016.12.002
ISSN号: 0014-4886
WOS记录号: WOS:000393541700001
PM记录号: 27940018
IR记录号: WOS:000393541700001
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内容类型: 期刊论文
URI标识: http://ir.lzu.edu.cn/handle/262010/189423
Appears in Collections:生命科学学院_期刊论文

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Recommended Citation:
Zhu, LR,Wang, L,Ju, FR,et al. Reversible recovery of neuronal structures depends on the degree of neuronal damage after global cerebral ischemia in mice[J]. EXPERIMENTAL NEUROLOGY,2017,289:1-8.
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