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兰州大学机构库  > 化学化工学院  > 期刊论文
题名: Bioactive Glycosides from the Twigs of Litsea cubeba
作者: Wang, LY; Chen, MH; Wu, J; Sun, H; Liu, W; Qu, YH; Li, YC; Wu, YZ; Li, R; Zhang, D; Wang, SJ; Lin, S
收录类别: SCIE ; PUBMED ; MEDLINE
出版日期: 2017-06
刊名: JOURNAL OF NATURAL PRODUCTS
卷号: 80, 期号:6, 页码:1808-1818
出版者: AMER CHEMICAL SOC
出版地: WASHINGTON
英文摘要: The air-dried twigs of Litsea cubeba, a traditional Chinese medicinal tree, afforded 10 new aromatic glycosides (1-10) and 26 known analogues. Their structures were assigned by extensive 1D and 2D NMR experiments, and the absolute configurations were resolved by chemical methods, electronic circular dichroism, specific rotation, and X-ray crystallographic analysis. Compound 4 is the first example of a naturally occurring homoneolignan glucoside. Compounds 4, 6-8, and the known neolignan glucosides (11, 12, and 14) at respective 10 mu M concentrations were found to reduce acetaminophen-induced HepG2 cell injury with 30.5-46.0% inhibitions. Furthermore, compounds 12 and 15 demonstrated moderate inhibitory activities against HDACl, with IC50 values of 3.6 and 4.6 mu M, respectively.
作者部门: [Wang, Ling-Yan ; Sun, Hua ; Liu, Wei ; Qu, Yu-Hong ; Li, Yan-Cheng ; Wu, Yu-Zhuo ; Li, Rui ; Zhang, Dan ; Wang, Su-Juan ; Lin, Sheng] Chinese Acad Med Sci, State Key Lab Bioact Subst & Funct Nat Med, Inst Mat Med, Beijing 100050, Peoples R China ; [Wang, Ling-Yan ; Sun, Hua ; Liu, Wei ; Qu, Yu-Hong ; Li, Yan-Cheng ; Wu, Yu-Zhuo ; Li, Rui ; Zhang, Dan ; Wang, Su-Juan ; Lin, Sheng] Chinese Acad Med Sci, Inst Med Biotechnol, Beijing 100050, Peoples R China ; [Wang, Ling-Yan ; Sun, Hua ; Liu, Wei ; Qu, Yu-Hong ; Li, Yan-Cheng ; Wu, Yu-Zhuo ; Li, Rui ; Zhang, Dan ; Wang, Su-Juan ; Lin, Sheng] Peking Union Med Coll, Beijing 100050, Peoples R China ; [Wu, Jiang] Lanzhou Univ, Coll Chem & Chem Engn, Lanzhou 730000, Peoples R China
通讯作者: Lin, S (reprint author), Chinese Acad Med Sci, State Key Lab Bioact Subst & Funct Nat Med, Inst Mat Med, Beijing 100050, Peoples R China. ; Lin, S (reprint author), Chinese Acad Med Sci, Inst Med Biotechnol, Beijing 100050, Peoples R China. ; Lin, S (reprint author), Peking Union Med Coll, Beijing 100050, Peoples R China.
学科分类: Plant Sciences; Pharmacology & Pharmacy
文章类型: Article
所属项目编号: National Natural Science Foundation of China (NNSFC) [81522050] ; Beijing Excellent Talents Program [2013D009008000002] ; Excellent Young Scholar Fund of State Key Laboratory of Bioactive Substance and Function of Natural Medicines [GTZB201202]
所属项目名称: 国家自然科学基金项目
项目资助者: NSFC
语种: 英语
DOI: 10.1021/acs.jnatprod.6b01189
ISSN号: 0163-3864
WOS记录号: WOS:000404322100013
PM记录号: 28541690
IR记录号: WOS:000404322100013
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内容类型: 期刊论文
URI标识: http://ir.lzu.edu.cn/handle/262010/190178
Appears in Collections:化学化工学院_期刊论文

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作者单位: 16CHEM

Recommended Citation:
Wang, LY,Chen, MH,Wu, J,et al. Bioactive Glycosides from the Twigs of Litsea cubeba[J]. JOURNAL OF NATURAL PRODUCTS,2017,80(6):1808-1818.
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