兰州大学机构库 >化学化工学院
Bioactive Glycosides from the Twigs of Litsea cubeba
Wang, LY; Chen, MH; Wu, J; Sun, H; Liu, W; Qu, YH; Li, YC; Wu, YZ; Li, R; Zhang, D; Wang, SJ; Lin, S; Lin, S (reprint author), Chinese Acad Med Sci, State Key Lab Bioact Subst & Funct Nat Med, Inst Mat Med, Beijing 100050, Peoples R China.; Lin, S (reprint author), Chinese Acad Med Sci, Inst Med Biotechnol, Beijing 100050, Peoples R China.; Lin, S (reprint author), Peking Union Med Coll, Beijing 100050, Peoples R China.
收录类别SCIE ; PUBMED ; MEDLINE
2017-06
发表期刊JOURNAL OF NATURAL PRODUCTS
卷号80期号:6页码:1808-1818
出版者AMER CHEMICAL SOC
出版地WASHINGTON
摘要The air-dried twigs of Litsea cubeba, a traditional Chinese medicinal tree, afforded 10 new aromatic glycosides (1-10) and 26 known analogues. Their structures were assigned by extensive 1D and 2D NMR experiments, and the absolute configurations were resolved by chemical methods, electronic circular dichroism, specific rotation, and X-ray crystallographic analysis. Compound 4 is the first example of a naturally occurring homoneolignan glucoside. Compounds 4, 6-8, and the known neolignan glucosides (11, 12, and 14) at respective 10 mu M concentrations were found to reduce acetaminophen-induced HepG2 cell injury with 30.5-46.0% inhibitions. Furthermore, compounds 12 and 15 demonstrated moderate inhibitory activities against HDACl, with IC50 values of 3.6 and 4.6 mu M, respectively.
作者部门
[Wang, Ling-Yan;
Sun, Hua;
Liu, Wei;
Qu, Yu-Hong;
Li, Yan-Cheng;
Wu, Yu-Zhuo;
Li, Rui;
Zhang, Dan;
Wang, Su-Juan;
Lin, Sheng] Chinese Acad Med Sci, State Key Lab Bioact Subst & Funct Nat Med, Inst Mat Med, Beijing 100050, Peoples R China...更多
学科领域Plant Sciences ; Pharmacology & Pharmacy
所属项目编号National Natural Science Foundation of China (NNSFC) [81522050] ; Beijing Excellent Talents Program [2013D009008000002] ; Excellent Young Scholar Fund of State Key Laboratory of Bioactive Substance and Function of Natural Medicines [GTZB201202]
资助项目国家自然科学基金项目
项目资助者NSFC
DOI10.1021/acs.jnatprod.6b01189
ISSN0163-3864
文章类型Article
语种英语
WOS记录号WOS:000404322100013
PM记录号28541690
IR记录号WOS:000404322100013
第一机构
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文献类型期刊论文
条目标识符http://ir.lzu.edu.cn/handle/262010/190178
Collection化学化工学院
通讯作者Lin, S (reprint author), Chinese Acad Med Sci, State Key Lab Bioact Subst & Funct Nat Med, Inst Mat Med, Beijing 100050, Peoples R China.; Lin, S (reprint author), Chinese Acad Med Sci, Inst Med Biotechnol, Beijing 100050, Peoples R China.; Lin, S (reprint author), Peking Union Med Coll, Beijing 100050, Peoples R China.
作者单位16CHEM
Recommended Citation:
GB/T 7714
Wang, LY,Chen, MH,Wu, J,et al. Bioactive Glycosides from the Twigs of Litsea cubeba[J]. JOURNAL OF NATURAL PRODUCTS,2017,80(6):1808-1818.
APA Wang, LY.,Chen, MH.,Wu, J.,Sun, H.,Liu, W.,...&Lin, S .(2017).Bioactive Glycosides from the Twigs of Litsea cubeba.JOURNAL OF NATURAL PRODUCTS,80(6),1808-1818.
MLA Wang, LY,et al."Bioactive Glycosides from the Twigs of Litsea cubeba".JOURNAL OF NATURAL PRODUCTS 80.6(2017):1808-1818.
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