兰州大学机构库 >基础医学院
Sodium Tanshinone IIA Sulfonate Prevents Radiation-Induced Toxicity in H9c2 Cardiomyocytes
Zhang, WJ; Li, Y; Li, R; Wang, YY; Zhu, MW; Wang, BW; Li, YL; Li, DY; Xie, P; Liu, B(刘斌); Liu, B (reprint author), Lanzhou Univ, Sch Stomatol, Lanzhou 730000, Gansu, Peoples R China.; Xie, P (reprint author), Gansu Prov Hosp Lanzhou, Dept Cardiol, Lanzhou 730000, Gansu, Peoples R China.
Indexed BySCIE
2017
Source PublicationEVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
ISSN1741-427X
AbstractThe present study was designed to elucidate the key parameters associated with X-ray radiation induced oxidative stress and the effects of STS on X-ray-induced toxicity in H9c2 cardiomyocytes. Cytotoxicity of STS and radiation was assessed by MTT. Antioxidant activity was evaluated by SOD and MDA. Apoptosis was measured by the flow cytometry, Hoechst 33258, clonogenic survival assay, and western blot. It was found that the cell viability of H9c2 cells exposed to X-ray radiation was significantly decreased in a dose-dependent manner and was associated with cell cycle arrest at the G0/G1 phase as well as apoptosis. STS treatment significantly reversed the morphological changes, attenuated radiation-induced apoptosis, and improved the antioxidant activity in the H9c2 cells. STS significantly increased the Bcl-2 and Bcl-2/Bax levels and decreased the Bax and caspase-3 levels, compared with the cells treated with radiation alone. STS treatment also resulted in a significant increase in p38-MAPK activation. STS could protect the cells fromX-ray-induced cell cycle arrest, oxidative stress, and apoptosis. Therefore, we suggest the STS could be useful for the treatment of radiation-induced cardiovascular injury.
Subject AreaIntegrative & Complementary Medicine
PublisherHINDAWI
Publication PlaceLONDON
DOI10.1155/2017/4537974
First Inst
Language英语
Project NumberCardiovascular Institute of Gansu Provincial Hospital ; School of Stomatology of Lanzhou University
Funding Project兰州大学医学科研基金
Funding OrganizationLZU ; GS-OTHER
SubtypeArticle
WOS IDWOS:000398499000001
IRIDWOS:000398499000001
Department
[Zhang, Wenjing] Gansu Univ Tradit Chinese Med, Sch Clin Med, Lanzhou 730000, Gansu, Peoples R China;
[Li, Yi] Lanzhou Univ, Sch Basic Med Sci, Inst Med Genet, Lanzhou 730000, Peoples R China;
[Li, Yi] Gansu Cardiovasc Inst, Lanzhou 730050, Peoples R China;
[Li, Rui;
Zhu, Mengwen;
Liu, Bin] Lanzhou Univ, Sch Stomatol, Lanzhou 730000, Gansu, Peoples R China;
[Wang, Yaya] Ningxia Med Univ, Sch Clin Med, Yinchuan 750000, Ningxia Hui Aut, Peoples R China;
[Wang, Bowen;
Li, Yanling;
Xie, Ping] Gansu Prov Hosp Lanzhou, Dept Cardiol, Lanzhou 730000, Gansu, Peoples R China...更多
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Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.lzu.edu.cn/handle/262010/190436
Collection基础医学院
Corresponding AuthorLiu, B (reprint author), Lanzhou Univ, Sch Stomatol, Lanzhou 730000, Gansu, Peoples R China.; Xie, P (reprint author), Gansu Prov Hosp Lanzhou, Dept Cardiol, Lanzhou 730000, Gansu, Peoples R China.
Affiliation23BASICMED
Recommended Citation
GB/T 7714
Zhang, WJ,Li, Y,Li, R,et al. Sodium Tanshinone IIA Sulfonate Prevents Radiation-Induced Toxicity in H9c2 Cardiomyocytes[J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2017.
APA Zhang, WJ.,Li, Y.,Li, R.,Wang, YY.,Zhu, MW.,...&Xie, P .(2017).Sodium Tanshinone IIA Sulfonate Prevents Radiation-Induced Toxicity in H9c2 Cardiomyocytes.EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE.
MLA Zhang, WJ,et al."Sodium Tanshinone IIA Sulfonate Prevents Radiation-Induced Toxicity in H9c2 Cardiomyocytes".EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2017).
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