兰州大学机构库 >第二临床医学院
Impact of type 2 diabetes mellitus on short-term and long-term outcomes of patients with esophageal squamous cell cancer undergoing resection: a propensity score analysis
Yao, W; Meng, YQ; Lu, MJ; Fan, WZ; Huang, JH; Li, JP; Zhu, ZH; Zhu, ZH (reprint author), Sun Yat Sen Univ, Ctr Canc, State Key Lab Oncol South China, Collaborat Innovat Ctr Canc Med, Guangzhou 510060, Guangdong, Peoples R China.; Li, JP (reprint author), Sun Yat Sen Univ, Affiliated Hosp 1, Dept Intervent Oncol, 58 Zhongshan Second Rd, Guangzhou 510080, Guangdong, Peoples R China.
收录类别SCIE ; PUBMED
2018-04-27
发表期刊CANCER COMMUNICATIONS
卷号38期号:9
出版者BIOMED CENTRAL LTD
出版地LONDON
摘要Background: The association between type 2 diabetes mellitus (T2DM) and the risk of esophageal cancer remains unclear. The present study aimed to evaluate the impact of T2DM on short-term outcomes and long-term survival in patients with esophageal squamous cell cancer (ESCC). Methods: The present retrospective study included 862 patients diagnosed with ESCC between January 2001 and December 2010. Among them, 280 patients had T2DM. A 1: 1 propensity score-matched cohort consisting of 280 patients with and 280 without T2DM was selected from the 862 patients. The associations between T2DM and clinicopathologic characteristics were assessed using the X-2 or Fisher's exact test. Survival of ESCC patients with and without T2DM was calculated by using the Kaplan-Meier method and compared by using the Cox regression model between the two groups. Results: The occurrence rate of anastomotic leakage was significantly higher in patients with T2DM than in those without T2DM (P < 0.001). In the subgroup with weight loss rate <= 5.05%, ESCC patients with T2DM had a significant longer overall survival than did those without T2DM (P = 0.003), whereas in the subgroup with weight loss rate > 5.05%, the patients without T2DM showed a longer survival (P = 0.001). Univariate and multivariate analysis results showed that T2DM was not an independent prognostic factor for patient survival. Conclusions: Type 2 diabetes mellitus is not an independent prognostic factor in patients with ESCC. However, the combination of T2DM with severe weight loss Dwould be a predictor of poor prognosis.
关键词Type 2 diabetes mellitus Esophageal cancer Prognosis Overall survival
作者部门
[Yao, Wang;
Meng, Yuqi;
Lu, Mingjian;
Huang, Jinhua;
Zhu, Zhihua] Sun Yat Sen Univ, Ctr Canc, State Key Lab Oncol South China, Collaborat Innovat Ctr Canc Med, Guangzhou 510060, Guangdong, Peoples R China;
[Yao, Wang;
Fan, Wenzhe;
Li, Jiaping] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Intervent Oncol, 58 Zhongshan Second Rd, Guangzhou 510080, Guangdong, Peoples R China;
[Meng, Yuqi] Lanzhou Univ, Hosp 2, Dept Thorac Surg, Lanzhou 730030, Gansu, Peoples R China;
[Lu, Mingjian] Guangzhou Med Univ, Affiliated Canc Hosp & Inst, Dept Radiol, Guangzhou 510060, Guangdong, Peoples R China...更多
DOI10.1186/s40880-018-0275-2
ISSN2523-3548
文章类型Article
语种英语
WOS记录号WOS:000434483000002
PM记录号29764483
第一机构
Citation statistics
文献类型期刊论文
条目标识符http://ir.lzu.edu.cn/handle/262010/197869
Collection第二临床医学院
通讯作者Zhu, ZH (reprint author), Sun Yat Sen Univ, Ctr Canc, State Key Lab Oncol South China, Collaborat Innovat Ctr Canc Med, Guangzhou 510060, Guangdong, Peoples R China.; Li, JP (reprint author), Sun Yat Sen Univ, Affiliated Hosp 1, Dept Intervent Oncol, 58 Zhongshan Second Rd, Guangzhou 510080, Guangdong, Peoples R China.
Recommended Citation:
GB/T 7714
Yao, W,Meng, YQ,Lu, MJ,et al. Impact of type 2 diabetes mellitus on short-term and long-term outcomes of patients with esophageal squamous cell cancer undergoing resection: a propensity score analysis[J]. CANCER COMMUNICATIONS,2018,38(9).
APA Yao, W.,Meng, YQ.,Lu, MJ.,Fan, WZ.,Huang, JH.,...&Li, JP .(2018).Impact of type 2 diabetes mellitus on short-term and long-term outcomes of patients with esophageal squamous cell cancer undergoing resection: a propensity score analysis.CANCER COMMUNICATIONS,38(9).
MLA Yao, W,et al."Impact of type 2 diabetes mellitus on short-term and long-term outcomes of patients with esophageal squamous cell cancer undergoing resection: a propensity score analysis".CANCER COMMUNICATIONS 38.9(2018).
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