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题名: Impact of type 2 diabetes mellitus on short-term and long-term outcomes of patients with esophageal squamous cell cancer undergoing resection: a propensity score analysis
作者: Yao, W; Meng, YQ; Lu, MJ; Fan, WZ; Huang, JH; Li, JP; Zhu, ZH
收录类别: SCIE ; PUBMED
出版日期: 2018-04-27
刊名: CANCER COMMUNICATIONS
卷号: 38, 期号:9
出版者: BIOMED CENTRAL LTD
出版地: LONDON
英文摘要: Background: The association between type 2 diabetes mellitus (T2DM) and the risk of esophageal cancer remains unclear. The present study aimed to evaluate the impact of T2DM on short-term outcomes and long-term survival in patients with esophageal squamous cell cancer (ESCC). Methods: The present retrospective study included 862 patients diagnosed with ESCC between January 2001 and December 2010. Among them, 280 patients had T2DM. A 1: 1 propensity score-matched cohort consisting of 280 patients with and 280 without T2DM was selected from the 862 patients. The associations between T2DM and clinicopathologic characteristics were assessed using the X-2 or Fisher's exact test. Survival of ESCC patients with and without T2DM was calculated by using the Kaplan-Meier method and compared by using the Cox regression model between the two groups. Results: The occurrence rate of anastomotic leakage was significantly higher in patients with T2DM than in those without T2DM (P < 0.001). In the subgroup with weight loss rate <= 5.05%, ESCC patients with T2DM had a significant longer overall survival than did those without T2DM (P = 0.003), whereas in the subgroup with weight loss rate > 5.05%, the patients without T2DM showed a longer survival (P = 0.001). Univariate and multivariate analysis results showed that T2DM was not an independent prognostic factor for patient survival. Conclusions: Type 2 diabetes mellitus is not an independent prognostic factor in patients with ESCC. However, the combination of T2DM with severe weight loss Dwould be a predictor of poor prognosis.
关键词: Type 2 diabetes mellitus ; Esophageal cancer ; Prognosis ; Overall survival
作者部门: [Yao, Wang ; Meng, Yuqi ; Lu, Mingjian ; Huang, Jinhua ; Zhu, Zhihua] Sun Yat Sen Univ, Ctr Canc, State Key Lab Oncol South China, Collaborat Innovat Ctr Canc Med, Guangzhou 510060, Guangdong, Peoples R China ; [Yao, Wang ; Fan, Wenzhe ; Li, Jiaping] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Intervent Oncol, 58 Zhongshan Second Rd, Guangzhou 510080, Guangdong, Peoples R China ; [Meng, Yuqi] Lanzhou Univ, Hosp 2, Dept Thorac Surg, Lanzhou 730030, Gansu, Peoples R China ; [Lu, Mingjian] Guangzhou Med Univ, Affiliated Canc Hosp & Inst, Dept Radiol, Guangzhou 510060, Guangdong, Peoples R China
通讯作者: Zhu, ZH (reprint author), Sun Yat Sen Univ, Ctr Canc, State Key Lab Oncol South China, Collaborat Innovat Ctr Canc Med, Guangzhou 510060, Guangdong, Peoples R China. ; Li, JP (reprint author), Sun Yat Sen Univ, Affiliated Hosp 1, Dept Intervent Oncol, 58 Zhongshan Second Rd, Guangzhou 510080, Guangdong, Peoples R China.
文章类型: Article
语种: 英语
DOI: 10.1186/s40880-018-0275-2
ISSN号: 2523-3548
WOS记录号: WOS:000434483000002
PM记录号: 29764483
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内容类型: 期刊论文
URI标识: http://ir.lzu.edu.cn/handle/262010/197869
Appears in Collections:第二临床医学院_期刊论文

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Recommended Citation:
Yao, W,Meng, YQ,Lu, MJ,et al. Impact of type 2 diabetes mellitus on short-term and long-term outcomes of patients with esophageal squamous cell cancer undergoing resection: a propensity score analysis[J]. CANCER COMMUNICATIONS,2018,38(9).
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