兰州大学机构库 >药学院
Biologically active quinoline and quinazoline alkaloids part I
Shang, Xiao-Fei1,3; Morris-Natschke, Susan L.2; Liu, YQ(刘映前)1; Guo, Xiao3; Xu, Xiao-Shan1; Goto, Masuo2; Li, Jun-Cai1; Yang, Guan-Zhou1; Lee, Kuo-Hsiung2,4
Indexed BySCIE ; PUBMED
2018-05
Source PublicationMEDICINAL RESEARCH REVIEWS
ISSN0198-6325
Volume38Issue:3Pages:775-828
AbstractQuinoline and quinazoline alkaloids, two important classes of N-based heterocyclic compounds, have attracted tremendous attention from researchers worldwide since the 19th century. Over the past 200 years, many compounds from these two classes were isolated from natural sources, and most of them and their modified analogs possess significant bioactivities. Quinine and camptothecin are two of the most famous and important quinoline alkaloids, and their discoveries opened new areas in antimalarial and anticancer drug development, respectively. In this review, we survey the literature on bioactive alkaloids from these two classes and highlight research achievements prior to the year 2008 (Part I). Over 200 molecules with a broad range of bioactivities, including antitumor, antimalarial, antibacterial and antifungal, antiparasitic and insecticidal, antiviral, antiplatelet, anti-inflammatory, herbicidal, antioxidant and other activities, were reviewed. This survey should provide new clues or possibilities for the discovery of new and better drugs from the original naturally occurring quinoline and quinazoline alkaloids.
Keywordbioactivities camptothecin quinazoline alkaloids quinine quinoline alkaloids
DOI10.1002/med.21466
First Inst
Language英语
Project NumberNational Natural Science Foundation of China [31371975, 21672092, 31302136] ; Fundamental Research Funds for the Central Universities [lzujbky-2016-147] ; Youth Science Foundation of Gansu Province [1506RJYA144] ; NIH grant from the National Cancer Institute [CA177584]
Funding Project国家自然科学基金项目 ; 中央高校基本科研业务费专项资金 ; 甘肃省自然科学基金计划 ; 甘肃省青年科技基金计划
Funding OrganizationNSFC ; LZU ; GSSTD
WOS Research AreaPharmacology & Pharmacy
WOS SubjectChemistry, Medicinal ; Pharmacology & Pharmacy
WOS IDWOS:000430126600002
PublisherWILEY
Original Document TypeReview
PMID 28902434
Citation statistics
Cited Times:56[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.lzu.edu.cn/handle/262010/198088
Collection药学院
Corresponding AuthorLiu, Ying-Qian; Lee, Kuo-Hsiung
Affiliation1.Lanzhou Univ, Sch Pharm, Lanzhou 730000, Gansu, Peoples R China
2.Univ N Carolina, UNC Eshelman Sch Pharm, Nat Prod Res Labs, Chapel Hill, NC USA
3.Chinese Acad Agr Sci, Lanzhou Inst Husb & Pharmaceut Sci, Key Lab Vet Pharmaceut Dev, Minist Agr, Lanzhou, Gansu, Peoples R China
4.China Med Univ & Hosp, Chinese Med Res & Dev Ctr, Taichung, Taiwan
First Author AffilicationSchool of Pharmacy
Corresponding Author AffilicationSchool of Pharmacy
Recommended Citation
GB/T 7714
Shang, Xiao-Fei,Morris-Natschke, Susan L.,Liu, Ying-Qian,et al. Biologically active quinoline and quinazoline alkaloids part I[J]. MEDICINAL RESEARCH REVIEWS,2018,38(3):775-828.
APA Shang, Xiao-Fei.,Morris-Natschke, Susan L..,Liu, Ying-Qian.,Guo, Xiao.,Xu, Xiao-Shan.,...&Lee, Kuo-Hsiung.(2018).Biologically active quinoline and quinazoline alkaloids part I.MEDICINAL RESEARCH REVIEWS,38(3),775-828.
MLA Shang, Xiao-Fei,et al."Biologically active quinoline and quinazoline alkaloids part I".MEDICINAL RESEARCH REVIEWS 38.3(2018):775-828.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Altmetrics Score
Google Scholar
Similar articles in Google Scholar
[Shang, Xiao-Fei]'s Articles
[Morris-Natschke, Susan L.]'s Articles
[Liu, Ying-Qian]'s Articles
Baidu academic
Similar articles in Baidu academic
[Shang, Xiao-Fei]'s Articles
[Morris-Natschke, Susan L.]'s Articles
[Liu, Ying-Qian]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Shang, Xiao-Fei]'s Articles
[Morris-Natschke, Susan L.]'s Articles
[Liu, Ying-Qian]'s Articles
Terms of Use
No data!
Social Bookmark/Share
No comment.
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.