兰州大学机构库 >化学化工学院
Fabrication of biocleavable crosslinked polyprodrug vesicles via reversible donor-acceptor interactions for enhanced anticancer drug delivery
Zhang, Xiaolong1,2; Hua, Qi1,2; Meng, Ping1,2; Wang, Mingqi1,2; Wang, Yunfei1,2; Sun, Lu1,2; Ma, LW(马丽微)1,2; Wang, BY(王宝燕)1,2; Yu, Cuiyun3,4; Wei, H(魏华)1,2,3,4
Indexed BySCI
2019-06-07
Source PublicationPOLYMER CHEMISTRY
Volume10Issue:21Pages:2666-2673
Abstract

Incorporation of various dynamic stimuli-responsive bonds to nanocarriers has been repeatedly highlighted to provide an elegant solution to the tradeoff between extracellular stability and intracellular high therapeutic efficiency; however, most of the developed systems still suffer from drug leakage-associated side effects due to insufficient stability and unsatisfactory therapeutic efficiency attributed to low drug loading capacity. To further address these critical issues, herein we reported a coordination-driven formation of biocleavable crosslinked polyprodrug vesicles (CPV) based on the reversible coordination interactions between the electron acceptor-containing polyprodrug and electron donor-based crosslinker, 1,6-hexanediamine. The resulting CPV exhibited a high drug loading content of 34.8%, and simultaneously enhanced extracellular micelle stability and promoted intracellular redox-triggered decrosslinking and drug release. More importantly, a comparison study further revealed that the CPV outperformed the noncrosslinked analogues in terms of greater stability, faster redox-triggered decrosslinking and drug release, a more compact structure with a smaller size toward higher cellular uptake, and greater in vitro cytotoxicity. This work thus developed a robust reversible crosslinking strategy to address high stability vs. sufficient therapeutic efficiency dilemma of polyprodrug-based nanocarriers.

Funding ProjectNational Key R&D Program of China[2018YFB1900201]
DOI10.1039/c9py00404a
ISSN1759-9954
Language英语
WOS Research AreaPolymer Science
WOS SubjectPolymer Science
WOS IDWOS:000469253500005
PublisherROYAL SOC CHEMISTRY
First Inst
Citation statistics
Document Type期刊论文
Identifierhttp://ir.lzu.edu.cn/handle/262010/270470
Collection化学化工学院
Affiliation1.Lanzhou Univ, Key Lab Nonferrous Met Chem & Resources Utilizat, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China
2.Lanzhou Univ, Coll Chem & Chem Engn, Lanzhou 730000, Gansu, Peoples R China
3.Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Peoples R China
4.Univ South China, Dept Pharm & Pharmacol, Hengyang 421001, Peoples R China
First Author AffilicationCollege of Chemistry and Chemical Engineering
Recommended Citation
GB/T 7714
Zhang, Xiaolong,Hua, Qi,Meng, Ping,et al. Fabrication of biocleavable crosslinked polyprodrug vesicles via reversible donor-acceptor interactions for enhanced anticancer drug delivery[J]. POLYMER CHEMISTRY,2019,10(21):2666-2673.
APA Zhang, Xiaolong.,Hua, Qi.,Meng, Ping.,Wang, Mingqi.,Wang, Yunfei.,...&Wei, Hua.(2019).Fabrication of biocleavable crosslinked polyprodrug vesicles via reversible donor-acceptor interactions for enhanced anticancer drug delivery.POLYMER CHEMISTRY,10(21),2666-2673.
MLA Zhang, Xiaolong,et al."Fabrication of biocleavable crosslinked polyprodrug vesicles via reversible donor-acceptor interactions for enhanced anticancer drug delivery".POLYMER CHEMISTRY 10.21(2019):2666-2673.
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