兰州大学机构库 >公共卫生学院
DosR antigen Rv1737c induces activation of macrophages dependent on the TLR2 pathway
Gao, Xiaoling1; Wu, Cong2; He, Wenhua2; Wang, XX(王晓霞)2; Li, Yonghong1; Wang, Yongxiang2; Jia, Yanjuan1; Yuan, Rui2; Li, Haojie2; Zhang, BZ(张本忠)2
2019-10
Source PublicationCELLULAR IMMUNOLOGY
ISSN0008-8749
Volume344
AbstractLatent Mycobacterium tuberculosis (Mtb) infection (LTBI) is the main clinical manifestation after Mtb exposure. During the latent phase, Mtb retards the attempts of eradication by the host immune system. The dormancy survival regulator (DosR) is held as essential for Mtb persistence. Rv1737c is predominantly expressed by the Mtb in latent infection. However, the role of Rv1737c in the immune evasion is still largely unknown. In this study, we have characterized the Rv1737c functions in the recruitment and activation of macrophages, which play a cardinal role in the innate and adaptive immunity. For the first time, we have revealed that Rv1737c induced the tolerogenic phenotype of macrophages by upregulating the expression of indoleamine 2,3-dioxygenase 1 (IDO1). Rv1737c-activated macrophages upregulated interleukin (IL)-4, IL-10, and Foxp3 T cells proliferation in vitro. Furthermore, the interaction of Rv1737c with macrophages was found to depend on the Toll-like receptor 2 (TLR2) pathway. It augmented nuclear factor kappa B (NF-kappa B) phosphorylation and co-stimulatory molecule expression. Thus, this study provides a crucial insight into a strategy adopted by Mtb to survive in the host by inducing tolerogenic macrophage expansion.
KeywordMycobacterium tuberculosis DosR antigens TLR2 Macrophages Immune modulation
DOI10.1016/j.cellimm.2019.103947
Indexed BySCIE
Language英语
Funding ProjectNational Natural Science Foundation of China[81360264]
WOS Research AreaCell Biology ; Immunology
WOS SubjectCell Biology ; Immunology
WOS IDWOS:000484766300004
PublisherACADEMIC PRESS INC ELSEVIER SCIENCE
Original Document TypeArticle
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.lzu.edu.cn/handle/262010/294274
Collection公共卫生学院
Corresponding AuthorGao, Xiaoling; Zhang, Benzhong
Affiliation1.Gansu Prov Hosp, Inst Clin Res & Translat Med, Lanzhou 730000, Gansu, Peoples R China
2.Lanzhou Univ, Sch Publ Hlth, Lanzhou 730000, Gansu, Peoples R China
Corresponding Author AffilicationSchool of Public health
Recommended Citation
GB/T 7714
Gao, Xiaoling,Wu, Cong,He, Wenhua,et al. DosR antigen Rv1737c induces activation of macrophages dependent on the TLR2 pathway[J]. CELLULAR IMMUNOLOGY,2019,344.
APA Gao, Xiaoling.,Wu, Cong.,He, Wenhua.,Wang, Xiaoxia.,Li, Yonghong.,...&Zhang, Benzhong.(2019).DosR antigen Rv1737c induces activation of macrophages dependent on the TLR2 pathway.CELLULAR IMMUNOLOGY,344.
MLA Gao, Xiaoling,et al."DosR antigen Rv1737c induces activation of macrophages dependent on the TLR2 pathway".CELLULAR IMMUNOLOGY 344(2019).
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