兰州大学机构库
A negative association between urinary iodine concentration and the prevalence of hyperuricemia and gout: a cross-sectional and population-based study in Mainland China
2020-02-20
Source PublicationEUROPEAN JOURNAL OF NUTRITION
ISSN1436-6207
AbstractBackground and aims Iodine is one of the most important trace elements in the human body. It is not only the main component of thyroid hormones but also has extrathyroid biological functions. To date, there have been no large-scale epidemiological studies on the relationship between hyperuricemia and iodine intake, although both are closely related to health. A population-based epidemiological survey in China offers such an opportunity. Methods This population-based cross-sectional study recruited 75,653 adults aged >= 18 years from 2015 to 2017 with a randomized, multistage, stratified sampling strategy. Serum uric acid levels and urinary iodine concentrations (UICs) were measured. Results Stratified by UIC, the prevalence of hyperuricemia was 17.8%, 18.8%, 16.0% and 13.7% in the UIC < 100, 100-199, 200-299, and >= 300 mu g/L groups, respectively; the prevalence of gout was 4.0%, 3.4%, 2.4% and 1.7%, respectively. The prevalence of gout decreased significantly as the UIC increased. The prevalence of hyperuricemia and gout were markedly higher in postmenopausal females than in the premenopausal population (hyperuricemia: 15.9% vs. 8.3%, X-2 = 520.072, p < 0.001; gout: 3.6% vs. 1.3%, X-2 = 219.889, p < 0.001), and the prevalence decreased as the UIC increased. Subjects in the more than adequate and excessive iodine groups had lower likelihoods of having hyperuricemia [aOR = 0.81 (95% CI 0.77-0.85), aOR = 0.68 (95% CI 0.64-0.72)] and lower odds of having gout than subjects in the adequate iodine (AI) group [aOR = 0.77 (95% CI 0.68-0.86), aOR = 0.59 (95% CI 0.51-0.68)]. Conclusions UIC was inversely associated with the occurrence of hyperuricemia and gout. More in-depth research and prospective studies are needed to explore the molecular mechanisms and confirm the observed association.
KeywordIodine Hyperuricemia Gout Prevalence Urinary iodine concentration
DOI10.1007/s00394-020-02199-z
Indexed BySCIE
Language英语
Funding ProjectResearch Fund for Public Welfare from the National Health and Family Planning Commission of China[201402005]
WOS Research AreaNutrition & Dietetics
WOS SubjectNutrition & Dietetics
WOS IDWOS:000516365100003
PublisherSPRINGER HEIDELBERG
Original Document TypeArticle ; Early Access
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.lzu.edu.cn/handle/262010/416949
Collection兰州大学
Corresponding AuthorShan, Zhongyan; Teng, Weiping
Affiliation1.China Med Univ, Hosp 1, Dept Endocrinol & Metab, 155 Nanjing Bei St, Shenyang 110001, Liaoning, Peoples R China
2.China Med Univ, Hosp 1, Inst Endocrinol, 155 Nanjing Bei St, Shenyang 110001, Liaoning, Peoples R China
3.Chinese Peoples Liberat Army Gen Hosp, Dept Endocrinol, Beijing 100853, Peoples R China
4.Third Mil Med Univ, Southwest Hosp, Dept Endocrinol, Chongqing 400038, Peoples R China
5.Dalian Med Univ, Affiliated Hosp 1, Dept Endocrinol, Dalian 116011, Liaoning, Peoples R China
6.Ningxia Med Univ Gen Hosp, Dept Endocrinol, Yinchuan 750004, Ningxia, Peoples R China
7.Ningxia Med Univ Gen Hosp, Cerebrovasc Dis Hosp, Yinchuan 750004, Ningxia, Peoples R China
8.Nanchang Univ, Affiliated Hosp 2, Dept Endocrinol & Metab, Nanchang 330006, Jiangxi, Peoples R China
9.Harbin Med Univ, Affiliated Hosp 1, Dept Endocrinol, Harbin 150001, Heilongjiang, Peoples R China
10.Hohhot First Hosp, Dept Endocrinol, Hohhot 010000, Inner Mongolia, Peoples R China
11.Cent South Univ, Xiangya Hosp 2, Dept Endocrinol & Metab, Changsha 410011, Hunan, Peoples R China
12.Nanjing Univ Chinese Med, Affiliated Hosp Integrated Tradit Chinese & Weste, Res Ctr Endocrine & Metab Dis, Nanjing 210028, Jiangsu, Peoples R China
13.Fujian Med Univ, Union Hosp, Fujian Inst Endocrinol, Dept Endocrinol & Metab, Fuzhou 350001, Fujian, Peoples R China
14.Zhengzhou Univ, Affiliated Hosp 1, Dept Internal Med, Div Endocrinol, Zhengzhou 450052, Henan, Peoples R China
15.Guangxi Med Univ, Affiliated Hosp 1, Dept Endocrine, Nanning 530021, Guangxi, Peoples R China
16.Hainan Gen Hosp, Dept Endocrinol, Haikou 570311, Hainan, Peoples R China
17.Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Endocrinol, Xian 710061, Shanxi, Peoples R China
18.Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Endocrinol, Wuhan 430022, Hubei, Peoples R China
19.Lanzhou Univ, Hosp 1, Dept Endocrinol, Lanzhou 730000, Gansu, Peoples R China
20.Sichuan Univ, West China Hosp, Dept Endocrinol & Metab, State Key Lab Biotherapy, Chengdu 610041, Sichuan, Peoples R China
21.Jilin Univ, Hosp 1, Dept Endocrinol & Metab, Changchun 130021, Jilin, Peoples R China
22.Shanghai Univ Med & Hlth Sci, Affiliated Zhoupu Hosp, Dept Endocrinol, Shanghai 201318, Peoples R China
23.An Hui Med Univ, Hosp 1, Dept Endocrinol, Hefei 230000, Anhui, Peoples R China
24.First Peoples Hosp Yunnan Prov, Dept Endocrinol, Kunming 650032, Yunnan, Peoples R China
25.Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Endocrinol & Metab, Guangzhou 510120, Guangdong, Peoples R China
26.Shanxi Med Univ, Hosp 1, Dept Endocrinol, Taiyuan 030001, Shanxi, Peoples R China
27.Peoples Hosp Tibet Autonomous Reg, Dept Endocrinol & Metab, Lhasa 850000, Tibet, Peoples R China
28.Qinghai Prov Peoples Hosp, Dept Endocrinol, Xining 810000, Qinghai, Peoples R China
29.Zhejiang Prov Ctr Dis Control & Prevent, Hangzhou 310051, Zhejiang, Peoples R China
30.Guiyang Med Univ, Affiliated Hosp, Dept Endocrinol & Metab, Guiyang 550004, Guizhou, Peoples R China
31.Hebei Med Univ, Hosp 2, Dept Endocrinol, Shijiazhuang 050000, Hebei, Peoples R China
32.Xinjiang Med Univ, Affiliated Hosp 1, Dept Endocrinol, Urumqi 830054, Xinjiang, Peoples R China
33.Tianjin Med Univ Gen Hosp, Dept Endocrinol & Metab, Tianjin 300052, Peoples R China
First Author AffilicationFirst Clinical School
Corresponding Author AffilicationFirst Clinical School
Recommended Citation
GB/T 7714
Lu, Xixuan,Shi, Xiaoguang,Li, Yanbo,et al. A negative association between urinary iodine concentration and the prevalence of hyperuricemia and gout: a cross-sectional and population-based study in Mainland China[J]. EUROPEAN JOURNAL OF NUTRITION,2020.
APA Lu, Xixuan.,Shi, Xiaoguang.,Li, Yanbo.,Chi, Haiyi.,Liao, Eryuan.,...&Teng, Weiping.(2020).A negative association between urinary iodine concentration and the prevalence of hyperuricemia and gout: a cross-sectional and population-based study in Mainland China.EUROPEAN JOURNAL OF NUTRITION.
MLA Lu, Xixuan,et al."A negative association between urinary iodine concentration and the prevalence of hyperuricemia and gout: a cross-sectional and population-based study in Mainland China".EUROPEAN JOURNAL OF NUTRITION (2020).
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