兰州大学机构库 >药学院
Discovery of luotonin A analogues as potent fungicides and insecticides: Design, synthesis and biological evaluation inspired by natural alkaloid
Yang, Guan-Zhou1; Zhang, Jian1; Peng, Jing-Wen1; Zhang, Zhi-Jun1; Zhao, Wen-Bin1; Wang, Ren-Xuan1; Ma, Kun-Yuan1; Li, Jun-Cai1; Liu, YQ(刘映前)1; Zhao, Zhong-Min1; Shang, Xiao-Fei1,2
2020-05-15
Source PublicationEUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
ISSN0223-5234
Volume194
AbstractThe prevention and control of plant diseases and insect pests is the most crucial issue facing crop protection. To discover novel pesticide candidates with diverse chemical structures from natural products, a series of luotonin A analogues were designed, synthesized and evaluated for their antifungal and insecticidal activities. Most of these compounds exhibited potent activity against Botrytis cinerea, Magnaporthe oryzae and Aphis craccivora. Among them, the antifungal activity of compound 10s against B. cinerea was comparable to azoxystrobin (EC50 = 0.09 mM) and against M. oryzae (EC50 = 0.19 mM) was slightly weaker than that of azoxystrobin (EC50 = 0.17 mM). Compounds 10k and 10o are the most active compounds against A. craccivora having identical mortality value of 42.05% at 50 mu g/mL, respectively, which were slightly lower than pymetrozine (51.14%) at the same concentration. Revealed morphological changes of the fungal cell surface by scanning electron microscopy indicated that luotonin A analogues might exert their antifungal activity by destroying fungal cell membrane and cell wall. Furthermore, the results of the in vivo protective and curative activities of the compound lOs against S. sclerotiorum and B. cinerea showed that the curative effect was stronger than its protective effect and the curative effects reached 67.17% and 73.82% at 80 mu g/mL respectively. The above results further demonstrated the potential of luotonin A analogues as novel fungicides and insecticides. (C) 2020 Elsevier Masson SAS. All rights reserved.
KeywordLuotonin A Insecticidal activity Fungicidal activity Synthesis
DOI10.1016/j.ejmech.2020.112253
Indexed BySCIE
Language英语
Funding ProjectNational Key Research and Development Program of China[2017YFD0201404] ; Key Program for International S&T Cooperation Projects of China Gansu Province[18YF1WA115] ; National Natural Science Foundation of China[31371975][21672092][31772790] ; Fundamental Research Funds for the Central Universities[lzujbky-2016-147][lzujbky-2017-k23]
WOS Research AreaPharmacology & Pharmacy
WOS SubjectChemistry, Medicinal
WOS IDWOS:000525871500011
PublisherELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
Original Document TypeArticle
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.lzu.edu.cn/handle/262010/418439
Collection药学院
Corresponding AuthorLiu, Ying-Qian
Affiliation1.Lanzhou Univ, Sch Pharm, Lanzhou 730000, Peoples R China
2.Chinese Acad Agr Sci, Lanzhou Inst Husb & Pharmaceut Sci, Lanzhou 730000, Peoples R China
First Author AffilicationSchool of Pharmacy
Corresponding Author AffilicationSchool of Pharmacy
Recommended Citation
GB/T 7714
Yang, Guan-Zhou,Zhang, Jian,Peng, Jing-Wen,et al. Discovery of luotonin A analogues as potent fungicides and insecticides: Design, synthesis and biological evaluation inspired by natural alkaloid[J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2020,194.
APA Yang, Guan-Zhou.,Zhang, Jian.,Peng, Jing-Wen.,Zhang, Zhi-Jun.,Zhao, Wen-Bin.,...&Shang, Xiao-Fei.(2020).Discovery of luotonin A analogues as potent fungicides and insecticides: Design, synthesis and biological evaluation inspired by natural alkaloid.EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,194.
MLA Yang, Guan-Zhou,et al."Discovery of luotonin A analogues as potent fungicides and insecticides: Design, synthesis and biological evaluation inspired by natural alkaloid".EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 194(2020).
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