兰州大学机构库 >化学化工学院
A smart tumor-microenvironment responsive nanoprobe for highly selective and efficient combination therapy
Fan, Yifan1; GuaN, Shanli2; Fang, Wenpeng1; Li, Pengyun2; Hu, Binbin1; Shan, Changfu1; Wu, Wenyu1; Cao, Jing1; Cheng, B(程博)2; Liu, WS(刘伟生)1; Tang, Y(唐瑜)1
2019-12
Source PublicationINORGANIC CHEMISTRY FRONTIERS
ISSN2052-1553
Volume6Issue:12Pages:3562-3568
AbstractThe therapeutic effects of chemotherapy and photodynamic therapy (PDT) are limited seriously by tumor hypoxia and low cell uptake capacity. Herein, a smart tumor-microenvironment (TME) responsive nanoprobe was developed using pH-responsive and decomposed CeOx/Fe2O3 as a carrier not only to strengthen cell uptake capacity, increase drug packaging efficiency and modulate tumor hypoxia, but also to act as an acceptor of Forster resonance energy transfer (FRET) and achieve energy quenching of an excited photosensitizer. Due to the urchin-like hollow structures of the CeOx/Fe2O3 carrier, the chemotherapy drug doxorubicin (DOX) and the photosensitizer chlorine e6 (Ce6) could be co-loaded to form the nanoprobe CeOx/Fe2O3-C&D. In normal tissue, the nanoprobe CeOx/Fe2O3-C&D showed weak cytotoxicity. Once in the TME, the CeOx/Fe2O3 nanoshells began to break up, DOX was released rapidly at the tumor site, and CeOx/Fe2O3 showed catalase-like activity to decompose endogenous H2O2 and produce O-2 persistently to overcome hypoxia in situ. Meanwhile the Ce6 was transformed from a "silent state" to an "activated state", generating the fluorescence signal and singlet oxygen (O-1(2)) by weakening the FRET efficiency. Therefore, our study showcases an innovative strategy to enhance cell uptake capacity, adjust tumor hypoxia and achieve highly selective and specific combination therapy.
DOI10.1039/c9qi01076a
Indexed BySCIE
Language英语
Funding ProjectNational Natural Science Foundation of China[21601074][21871121][31771447][31970624] ; Fundamental Research Funds for the Central Universities[lzujbky-2018-ot01][lzujbky-2019-sp01][lzujbky-2019-kb12][lzujbky-2018-k05] ; Foundation of the Ministry of Education Key Laboratory of Cell Activities and Stress Adaptations[lzujbky-2018-kb05]
WOS Research AreaChemistry
WOS SubjectChemistry, Inorganic & Nuclear
WOS IDWOS:000501285400016
PublisherROYAL SOC CHEMISTRY
Original Document TypeArticle
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.lzu.edu.cn/handle/262010/418624
Collection化学化工学院
生命科学学院
Corresponding AuthorCao, Jing; Cheng, Bo; Tang, Yu
Affiliation1.Lanzhou Univ, Coll Chem & Chem Engn, Key Lab Nonferrous Met Chem & Resources Utilizat, State Key Lab OfAppl Organ Chem, Lanzhou 730000, Gansu, Peoples R China
2.Lanzhou Univ, Sch Life Sci, Minist Educ, Key Lab Cell Act & Stress Adaptat, Lanzhou 730000, Gansu, Peoples R China
First Author AffilicationCollege of Chemistry and Chemical Engineering
Corresponding Author AffilicationCollege of Chemistry and Chemical Engineering;  School of Life Sciences
Recommended Citation
GB/T 7714
Fan, Yifan,GuaN, Shanli,Fang, Wenpeng,et al. A smart tumor-microenvironment responsive nanoprobe for highly selective and efficient combination therapy[J]. INORGANIC CHEMISTRY FRONTIERS,2019,6(12):3562-3568.
APA Fan, Yifan.,GuaN, Shanli.,Fang, Wenpeng.,Li, Pengyun.,Hu, Binbin.,...&Tang, Yu.(2019).A smart tumor-microenvironment responsive nanoprobe for highly selective and efficient combination therapy.INORGANIC CHEMISTRY FRONTIERS,6(12),3562-3568.
MLA Fan, Yifan,et al."A smart tumor-microenvironment responsive nanoprobe for highly selective and efficient combination therapy".INORGANIC CHEMISTRY FRONTIERS 6.12(2019):3562-3568.
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