兰州大学机构库
Risk stratification and outcomes of intracranial hemorrhage in patients with immune thrombocytopenia under 60 years of age
Indexed BySCIE
2020-07-03
Source PublicationPLATELETS
ISSN0953-7104
AbstractIntracranial hemorrhage (ICH) is a devastating complication of immune thrombocytopenia (ITP). However, information on ICH in ITP patients under the age of 60 years is limited, and no predictive tools are available in clinical practice. A total of 93 adult patients with ITP who developed ICH before 60 years of age were retrospectively identified from 2005 to 2019 by 27 centers in China. For each case, 2 controls matched by the time of ITP diagnosis and the duration of ITP were provided by the same center. Multivariate analysis identified head trauma (OR = 3.216, 95%CI 1.296-7.979,P=.012), a platelet count <= 15,000/mu L at the time of ITP diagnosis (OR = 1.679, 95%CI 1.044-2.698,P=.032) and severe/life-threatening bleeding (severe bleedingvs. mild bleeding, OR = 1.910, 95%CI 1.088-3.353,P=.024; life-threatening bleedingvs. mild bleeding, OR = 2.620, 95%CI 1.360-5.051,P=.004) as independent risk factors for ICH. Intraparenchymal hemorrhage (OR = 5.191, 95%CI 1.717-15.692,P=.004) and a history of severe bleeding (OR = 4.322, 95%CI 1.532-12.198,P=.006) were associated with the 30-day outcome of ICH. These findings may facilitate ICH risk stratification and outcome prediction in patients with ITP.
KeywordImmune thrombocytopenia intracranial hemorrhage outcome risk stratification
DOI10.1080/09537104.2020.1786042
Language英语
Funding ProjectBeijing Municipal Science and Technology Commission[Z171100001017084] ; National Natural Science Foundation of China[81970113][81730004][81670116] ; Beijing Natural Science Foundation[H2018206423][7171013] ; National Key Research and Development Program of China[2017YFA0105500][2017YFA0105503] ; Foundation for Innovative Research Groups of the National Natural Science Foundation of China[81621001]
WOS Research AreaCell Biology ; Hematology
WOS SubjectCell Biology ; Hematology
WOS IDWOS:000547013500001
PublisherTAYLOR & FRANCIS INC
Original Document TypeArticle ; Early Access
Citation statistics
Document Type期刊论文
Identifierhttp://ir.lzu.edu.cn/handle/262010/421928
Collection兰州大学
Corresponding AuthorZhang, Xiao-Hui
Affiliation1.Peking Univ, Peoples Hosp, Inst Hematol, Beijing, Peoples R China
2.Natl Clin Res Ctr Hematol Dis, Beijing, Peoples R China
3.Beijing Key Lab Hematopoiet Stem Cell Transplanta, Beijing, Peoples R China
4.Peking Univ, Collaborat Innovat Ctr Hematol, Beijing, Peoples R China
5.Shandong Univ, Qilu Hosp, Dept Hematol, Jinan, Peoples R China
6.Chinese Peoples Liberat Army Gen Hosp, Dept Geriatr Hematol, Beijing, Peoples R China
7.Peking Univ, Dept Clin Epidemiol, Peoples Hosp, Beijing, Peoples R China
8.Nanchang Univ, Dept Hematol, Affiliated Hosp 1, Nanchang, Jiangxi, Peoples R China
9.Hainan Gen Hosp, Dept Hematol, Haikou, Hainan, Peoples R China
10.Sichuan Univ, West China Hosp, Dept Hemotol, Chengdu, Peoples R China
11.Xinjiang Med Univ, Dept Hematol, Affiliated Hosp 1, Urumqi, Peoples R China
12.Inner Mongolia Med Univ, Dept Hematol, Affiliated Hosp, Hohhot, Peoples R China
13.Fujian Med Univ, Fujian Inst Hematol, Union Hosp, Fuzhou, Peoples R China
14.Zhengzhou Univ, Dept Hematol, Affiliated Canc Hosp, Zhengzhou, Peoples R China
15.Kunming Med Univ, Dept Hematol, Affiliated Hosp 2, Kunming, Yunnan, Peoples R China
16.First Hosp Jilin Univ, Dept Hematol, Changchun, Peoples R China
17.Lanzhou Univ, Dept Hematol, Hosp 2, Lanzhou, Peoples R China
18.Shandong Univ, Dept Hematol, Shandong Prov Hosp, Jinan, Peoples R China
19.Tianjin Med Univ Gen Hosp, Dept Hematol, Tianjin, Peoples R China
20.Minist Hlth, Dept Hematol, Beijing Hosp, Beijing, Peoples R China
21.Shanxi Med Univ, Dept Hematol, Affiliated Hosp 2, Taiyuan, Peoples R China
22.Shanxi Med Univ, Dept Hematol, Affiliated Shanxi Big Hosp, Taiyuan, Peoples R China
23.Guangzhou First Peoples Hosp, Dept Hematol, Guangzhou, Peoples R China
24.Third Mil Med Univ, Xinqiao Hosp, Chongqing, Peoples R China
25.Peking Univ, Dept Hematol, Hosp 1, Beijing, Peoples R China
26.Shanghai Jiao Tong Univ, Rui Jin Hosp, Sch Med, Shanghai, Peoples R China
27.Nanfang Med Univ, Nanfang Hosp, Guangzhou, Peoples R China
28.Capital Med Univ, Beijing Luhe Hosp, Beijing, Peoples R China
29.Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Hematol, Beijing, Peoples R China
30.Capital Med Univ, Fuxing Hosp, Beijing, Peoples R China
31.Hebei Med Univ, Dept Hematol, Hosp 2, Shijiazhuang, Hebei, Peoples R China
32.Chinese Acad Sci, Collaborat Innovat Ctr Genet & Dev, Beijing Inst Genom, Key Lab Genom & Precis Med, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Zhao, Peng,Hou, Ming,Liu, Yi,et al. Risk stratification and outcomes of intracranial hemorrhage in patients with immune thrombocytopenia under 60 years of age[J]. PLATELETS,2020.
APA Zhao, Peng.,Hou, Ming.,Liu, Yi.,Liu, Hui-Xin.,Huang, Rui-Bin.,...&Zhang, Xiao-Hui.(2020).Risk stratification and outcomes of intracranial hemorrhage in patients with immune thrombocytopenia under 60 years of age.PLATELETS.
MLA Zhao, Peng,et al."Risk stratification and outcomes of intracranial hemorrhage in patients with immune thrombocytopenia under 60 years of age".PLATELETS (2020).
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