| Red emission ratio fluorescent probe for the activity of vanin-1 and imaging in vivo | |
| Qian, Jing1; Zhang, Liang2; Wang, Jiemin1; Teng, Zhidong3; Cao, Ting1; Zheng, Lei1; Cao, Yuping1; Qin, Wenwu1; Liu, Yun2; Guo, Huichen3 | |
| 2021-01-05 | |
| Source Publication | Journal of Hazardous Materials
 |
| ISSN | 03043894 |
| Volume | 401 |
| Abstract | Pantetheinase, also known as Vanin-1, catalyzes pantetheine to decompose into the precursor of CoA — pantothenic acid and aminothiol cysteamine. Studies have shown that Vanin-1 plays an important role in many important physiological pathologies. In this paper, a new red emission ratio fluorescent probe DCM-PA (I640 nm/I564 nm) has been implemented to detect the activity of Vanin-1 in cells and vivo. DCM-PA has short response time (30 min), high selectivity and low sensitivity (DL =0.69 ng/mL). Also, we have applied DCM-PA for imaging in cells and mice, and the results have indicated that the probe has a non-negligible potential for monitoring the activity of Vanin-1 in situ, benefiting further to study the role of Vanin-1 in physiology and pathology. In addition, the up-regulation of this enzyme by starvation confirmed the inevitable connection between diabetes and abnormal expression of Vanin-1. © 2020 Elsevier B.V. |
| Keyword | Fluorescence Mammals Pathology PhysiologyAminothiols Fluorescent probes High selectivity Low sensitivity Pantothenic acid Red emissions Short response time Up-regulation |
| Publisher | Elsevier B.V., Netherlands |
| DOI | 10.1016/j.jhazmat.2020.123863 |
| Indexed By | EI |
| Language | 英语 |
| EI Accession Number | 20203809200865 |
| EI Keywords | Probes |
| EI Classification Number | 461.6 Medicine and Pharmacology ; 461.9 Biology ; 741.1 Light/Optics |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.lzu.edu.cn/handle/262010/440616 |
| Collection | 兰州大学 |
| Corresponding Author | Qin, Wenwu |
| Affiliation | 1.State Key Laboratory of Applied Organic Chemistry, Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province and Key Laboratory of Special Function Materials and Structure Design (MOE), College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou; 730000, China; 2.Department of Radiology, Xinqiao Hospital, Army Medical University, Chongqing; 400037, China; 3.State Key Laboratory of Veterinary Etiological Biology and Key Laboratory of Animal Virology of Ministry of Agriculture, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Xujiaping 1, Lanzhou; Gansu Province; 730046, China |
| First Author Affilication | College of Chemistry and Chemical Engineering |
| Corresponding Author Affilication | College of Chemistry and Chemical Engineering |
| Recommended Citation GB/T 7714 | Qian, Jing,Zhang, Liang,Wang, Jiemin,et al. Red emission ratio fluorescent probe for the activity of vanin-1 and imaging in vivo[J]. Journal of Hazardous Materials,2021,401. |
| APA | Qian, Jing.,Zhang, Liang.,Wang, Jiemin.,Teng, Zhidong.,Cao, Ting.,...&Guo, Huichen.(2021).Red emission ratio fluorescent probe for the activity of vanin-1 and imaging in vivo.Journal of Hazardous Materials,401. |
| MLA | Qian, Jing,et al."Red emission ratio fluorescent probe for the activity of vanin-1 and imaging in vivo".Journal of Hazardous Materials 401(2021). |
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