| The Effect of Increased Iodine Intake on Serum Thyrotropin: A Cross-Sectional, Chinese Nationwide Study | |
| 2020-09-21 | |
| Source Publication | THYROID
 |
| ISSN | 1050-7256 |
| Abstract | Background:Subclinical hypothyroidism is diagnosed based on serum thyrotropin (TSH) reference intervals, which in turn are affected by many factors. Methods:Data were acquired from a Chinese nationally representative cross-sectional study of 78,470 participants (TIDE study). The total study population were participants from the TIDE program, and the reference population was a subset of the total population defined by the National Academy of Clinical Biochemistry (NACB) guidelines. Serum concentrations of thyroid hormones, TSH, thyroid antibodies, and urine iodine concentration (UIC) were measured. Results:The geometric mean serum TSH (2.5th-97.5th) for the reference population (defined by the NACB) and total population was 2.28 mIU/L (0.74-7.04 mIU/L) and 2.34 mIU/L (0.61-8.33 mIU/L), respectively. In the reference population, increase in UIC was significantly associated with increase in the 50th and 97.5th centiles and decrease in the 2.5th centile of TSH. The median TSH was significantly higher in women than in men (2.41 mIU/L vs. 2.16 mIU/L,p-value <0.001). Increased age was significantly associated with an increased TSH, 97.5th centile. For each 10-year increase in the population age, the TSH 97.5th centile increased by 0.534 mIU/L. The prevalence of subclinical hypothyroidism diagnosed according to the assay-recommended interval (Roche 0.27-4.2 mIU/L) and NACB standard interval in the TIDE study (0.74-7.04 mIU/L) differed significantly (Roche 13.61% vs. TIDE 3.00%,p < 0.05). However, there was no significant difference in future cardiovascular disease, reflected by the Framingham risk score, between the 0.27-4.2 and 4.2-7.04 mIU/L TSH groups. Conclusions:Serum TSH concentration significantly increased with increase in iodine intake. Thus, iodine intake must be considered in establishing TSH reference intervals. To avoid overdiagnosis and overtreatment of subclinical hypothyroidism, different areas should use individual serum TSH reference intervals. |
| Keyword | iodine TSH reference interval subclinical hypothyroidism |
| DOI | 10.1089/thy.2019.0842 |
| Indexed By | SCIE |
| Language | 英语 |
| Funding Project | Research Fund for Public Welfare, National Health and Family Planning Commission of China[201402005] ; Clinical Research Fund of the Chinese Medical Association[15010010589] |
| WOS Research Area | Endocrinology & Metabolism |
| WOS Subject | Endocrinology & Metabolism |
| WOS ID | WOS:000573837300001 |
| Publisher | MARY ANN LIEBERT, INC |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.lzu.edu.cn/handle/262010/441294 |
| Collection | 兰州大学 |
| Corresponding Author | Shan, Zhongyan; Teng, Weiping |
| Affiliation | 1.China Med Univ, Hosp 1, Dept Endocrinol & Metab, Shenyang, Peoples R China 2.China Med Univ, Hosp 1, Inst Endocrinol, Shenyang, Peoples R China 3.Chinese Peoples Liberat Army Gen Hosp, Dept Endocrinol, Beijing, Peoples R China 4.Third Mil Med Univ, Southwest Hosp, Dept Endocrinol, Chongqing, Peoples R China 5.Dalian Med Univ, Affiliated Hosp 1, Dept Endocrinol, Dalian, Peoples R China 6.Ningxia Med Univ, Cardiovasc & Cerebrovascular Dis Hosp, Dept Endocrinol, Yinchuan, Ningxia, Peoples R China 7.Nanchang Univ, Affiliated Hosp 2, Dept Endocrinol & Metab, Nanchang, Jiangxi, Peoples R China 8.Harbin Med Univ, Affiliated Hosp 1, Dept Endocrinol, Harbin, Peoples R China 9.Hohhot First Hosp, Dept Endocrinol, Hohhot, Peoples R China 10.Cent South Univ, Xiangya Hosp 2, Dept Endocrinol & Metab, Changsha, Peoples R China 11.Nanjing Univ Chinese Med, Res Ctr Endocrine & Metab Dis, Affiliated Hosp Integrated Tradit Chinese & Weste, Nanjing, Peoples R China 12.Fujian Med Univ, Union Hosp, Fujian Inst Endocrinol, Dept Endocrinol & Metab, Fuzhou, Peoples R China 13.Zhengzhou Univ, Div Endocrinol, Dept Internal Med, Affiliated Hosp 1, Zhengzhou, Peoples R China 14.Guangxi Med Univ, Affiliated Hosp 1, Dept Endocrine, Nanning, Peoples R China 15.Hainan Gen Hosp, Dept Endocrinol, Haikou, Hainan, Peoples R China 16.Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Endocrinol, Xian, Peoples R China 17.Huazhong Univ Sci & Technol, Dept Endocrinol, Union Hosp, Tongji Med Coll, Wuhan, Peoples R China 18.Lanzhou Univ, Hosp 1, Dept Endocrinol, Lanzhou, Peoples R China 19.Sichuan Univ, Dept Endocrinol & Metab, State Key Lab Biotherapy, West China Hosp, Chengdu, Peoples R China 20.Jilin Univ, Hosp 1, Dept Endocrinol & Metab, Changchun, Peoples R China 21.Shanghai Univ Med & Hlth Sci, Affiliated Zhoupu Hosp, Dept Endocrinol, Shanghai, Peoples R China 22.An Hui Med Univ, Hosp 1, Dept Endocrinol, Hefei, Peoples R China 23.First Peoples Hosp Yunnan Prov, Dept Endocrinol, Kunming, Yunnan, Peoples R China 24.Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Endocrinol & Metab, Guangzhou, Peoples R China 25.Shanxi Med Univ, Hosp 1, Dept Endocrinol, Taiyuan, Peoples R China 26.Peoples Hosp Tibet Autonomous Reg, Dept Endocrinol & Metab, Lhasa, Peoples R China 27.Qinghai Prov Peoples Hosp, Dept Endocrinol, Xining, Peoples R China 28.Zhejiang Prov Ctr Dis Control & Prevent, Hangzhou, Peoples R China 29.Guiyang Med Univ, Affiliated Hosp, Dept Endocrinol & Metab, Guiyang, Peoples R China 30.Hebei Med Univ, Hosp 2, Dept Endocrinol, Shijiazhuang, Hebei, Peoples R China 31.Xinjiang Med Univ, Affiliated Hosp 1, Dept Endocrinol, Urumqi, Peoples R China 32.Tianjin Med Univ, Gen Hosp, Dept Endocrinol & Metab, Tianjin, Peoples R China |
| First Author Affilication | First Clinical School |
| Corresponding Author Affilication | First Clinical School |
| Recommended Citation GB/T 7714 | Zhao, Lei,Teng, Di,Shi, Xiaoguang,et al. The Effect of Increased Iodine Intake on Serum Thyrotropin: A Cross-Sectional, Chinese Nationwide Study[J]. THYROID,2020. |
| APA | Zhao, Lei.,Teng, Di.,Shi, Xiaoguang.,Li, Yongze.,Ba, Jianming.,...&Teng, Weiping.(2020).The Effect of Increased Iodine Intake on Serum Thyrotropin: A Cross-Sectional, Chinese Nationwide Study.THYROID. |
| MLA | Zhao, Lei,et al."The Effect of Increased Iodine Intake on Serum Thyrotropin: A Cross-Sectional, Chinese Nationwide Study".THYROID (2020). |
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