兰州大学机构库
An Inverse Relationship Between Iodine Intake and Thyroid Antibodies: A National Cross-Sectional Survey in Mainland China
2020-07-23
Source PublicationTHYROID
ISSN1050-7256
AbstractBackground:Iodine intake is associated with thyroid autoimmunity. In this study, we evaluated the changes in thyroid autoimmunity after 20 years of universal salt iodization (USI) in China. Methods:A total of 78,470 subjects (18 years or older) from 31 provincial regions of mainland China participated in the study. Serum thyroid peroxidase antibody (TPOAb), thyroglobulin antibody (TgAb), TSH receptor antibody, thyrotropin (TSH), and urinary iodine concentration (UIC) were measured. Results:Positive TPOAb and TgAb were detected in 10.19% [CI 9.80-10.59] and 9.70% [CI 9.28-10.13] of the subjects, respectively. The prevalence of positive isolated TPOAb (i-TPOAb), positive isolated TgAb (i-TgAb), and double positive TPOAb and TgAb (d-Ab) was 4.52%, 4.16%, and 5.94%, respectively. The prevalence of thyroid antibody positivity was the highest in the iodine-deficient (UIC <100 mu g/L) groups. The prevalence of i-TPOAb was inversely associated with more than adequate iodine intake (MAI) and excessive iodine intake (EI); the odds ratio (OR) was 0.89 [CI 0.81-0.98] for MAI and 0.90 [CI 0.81-0.99] for EI. We observed that i-TgAb, like i-TPOAb, was a high-risk factor for subnormal TSH levels (OR = 3.64 [CI 2.62-5.05]) and elevated TSH levels (OR = 1.62 [CI 1.49-1.77]). The prevalence of thyroid antibody positivity varied among five ethnic groups. Conclusions:After two decades of USI, the prevalence of thyroid antibody positivity has remained low. MAI and EI had an inverse relationship with TPOAb positivity, which reveals that UIC between 100 and 299 mu g/L is optimal and safe for thyroid autoimmunity. These conclusions need to be confirmed in a follow-up study because this study was a cross-sectional study.
Keywordiodine thyroid antibody universal salt iodization China prevalence
DOI10.1089/thy.2020.0037
Indexed BySCIE
Language英语
Funding ProjectResearch Fund for Public Welfare from the National Health and Family Planning Commission of China[201402005]
WOS Research AreaEndocrinology & Metabolism
WOS SubjectEndocrinology & Metabolism
WOS IDWOS:000556078900001
PublisherMARY ANN LIEBERT, INC
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.lzu.edu.cn/handle/262010/441298
Collection兰州大学
Corresponding AuthorShan, Zhongyan; Teng, Weiping
Affiliation1.China Med Univ, Hosp 1, Inst Endocrinol, Dept Endocrinol & Metab, Shenyang, Peoples R China
2.Chinese Peoples Liberat Army Gen Hosp, Dept Endocrinol, Beijing, Peoples R China
3.Third Mil Med Univ, Southwest Hosp, Dept Endocrinol, Chongqing, Peoples R China
4.Dalian Med Univ, Affiliated Hosp 1, Dept Endocrinol, Dalian, Peoples R China
5.Ningxia Med Univ, Cardiovasc & Cerebrovasc Dis Hosp, Dept Endocrinol, Yinchuan, Ningxia, Peoples R China
6.Nanchang Univ, Affiliated Hosp 2, Dept Endocrinol & Metab, Nanchang, Jiangxi, Peoples R China
7.Harbin Med Univ, Affiliated Hosp 1, Dept Endocrinol, Harbin, Peoples R China
8.Hohhot First Hosp, Dept Endocrinol, Hohhot, Peoples R China
9.Cent South Univ, Xiangya Hosp 2, Dept Endocrinol & Metab, Changsha, Peoples R China
10.Nanjing Univ Chinese Med, Affiliated Hosp Integrated Tradit Chinese & Weste, Res Ctr Endocrine & Metab Dis, Nanjing, Peoples R China
11.Fujian Med Univ, Fujian Inst Endocrinol, Dept Endocrinol & Metab, Union Hosp, Fuzhou, Peoples R China
12.Zhengzhou Univ, Affiliated Hosp 1, Dept Internal Med, Div Endocrinol, Zhengzhou, Peoples R China
13.Guangxi Med Univ, Affiliated Hosp 1, Dept Endocrine, Nanning, Peoples R China
14.Hainan Gen Hosp, Dept Endocrinol, Haikou, Hainan, Peoples R China
15.Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Endocrinol, Xian, Peoples R China
16.Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Endocrinol, Wuhan, Peoples R China
17.Lanzhou Univ, Hosp 1, Dept Endocrinol, Lanzhou, Peoples R China
18.Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Dept Endocrinol & Metab, Chengdu, Peoples R China
19.Jilin Univ, Hosp 1, Dept Endocrinol & Metab, Changchun, Peoples R China
20.Shanghai Univ Med & Hlth Sci, Affiliated Zhoupu Hosp, Dept Endocrinol, Shanghai, Peoples R China
21.An Hui Med Univ, Hosp 1, Dept Endocrinol, Hefei, Peoples R China
22.First Peoples Hosp Yunnan Prov, Dept Endocrinol, Kunming, Yunnan, Peoples R China
23.Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Endocrinol & Metab, Guangzhou, Peoples R China
24.Shanxi Med Univ, Hosp 1, Dept Endocrinol, Taiyuan, Peoples R China
25.Peoples Hosp Tibet Autonomous Reg, Dept Endocrinol & Metab, Lhasa, Peoples R China
26.Qinghai Prov Peoples Hosp, Dept Endocrinol, Xining, Peoples R China
27.Zhejiang Prov Ctr Dis Control & Prevent, Hangzhou, Peoples R China
28.Guiyang Med Univ, Affiliated Hosp, Dept Endocrinol & Metab, Guiyang, Peoples R China
29.Hebei Med Univ, Hosp 2, Dept Endocrinol, Shijiazhuang, Hebei, Peoples R China
30.Xinjiang Med Univ, Affiliated Hosp 1, Dept Endocrinol, Urumqi, Peoples R China
31.Tianjin Med Univ, Gen Hosp, Dept Endocrinol & Metab, Tianjin, Peoples R China
First Author AffilicationFirst Clinical School
Corresponding Author AffilicationFirst Clinical School
Recommended Citation
GB/T 7714
Teng, Di,Yang, Wenqing,Shi, Xiaoguang,et al. An Inverse Relationship Between Iodine Intake and Thyroid Antibodies: A National Cross-Sectional Survey in Mainland China[J]. THYROID,2020.
APA Teng, Di.,Yang, Wenqing.,Shi, Xiaoguang.,Li, Yongze.,Ba, Jianming.,...&Teng, Weiping.(2020).An Inverse Relationship Between Iodine Intake and Thyroid Antibodies: A National Cross-Sectional Survey in Mainland China.THYROID.
MLA Teng, Di,et al."An Inverse Relationship Between Iodine Intake and Thyroid Antibodies: A National Cross-Sectional Survey in Mainland China".THYROID (2020).
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