兰州大学机构库 >化学化工学院
Eu3+/Tb3+ supramolecular assembly hybrids for ultrasensitive and ratiometric detection of anthrax spore biomarker in water solution and actual spore samples
Su, Pingru1; Wang, Xiaoyuan3; Wang, Tao1; Feng, Xiaoxia1; Zhang, Meina1; Liang, Lijuan1; Cao, Jing1; Liu, WS(刘伟生)1; Tang, Y(唐瑜)1,2
2021-04-01
Source PublicationTalanta
ISSN00399140
Volume225
AbstractRare earth (RE) complexes have found a variety of applications in materials science and biomedicine because of their unique luminescence properties. However, the poor stability and solubility in water of multicomponent RE assemblies significantly limit their practical applications. We rationally designed and developed a novel Eu3+/Tb3+ supramolecular assembly hybrids (Eu/Tb-SAH) by supramolecular host-guest recognition and coordination recognition with the excellent characteristics of water dispersion stability, biocompatibility and luminous properties. As anthrax spore biomarker, 2,6-pyridinedicarboxylic acid (DPA) can coordinate with Tb3+ and sensitize Tb3+, resulting in a proportional change of fluorescence intensity and lifetime on the ms timescales, thereby realizing rapid and sensitive detection of DPA in water media or actual spores. To confirm our prediction, accurate and selective detection of DPA was achieved with Eu/Tb-SAH as a nanoprobe through steady-state ratiometric fluorescence and time-resolved technology, of which the limit of detection (LOD) are 27.3 nM and 1.06 nM, respectively. This was obviously lower than the amount of anthrax spores infecting the human body (60 μM). Besides, the filter paper was used to carry out visual detection of DPA and read the corresponding data through smart phones. This work paves a new way to fabricate luminescent RE nanomaterials and provides new ideas for the design of ratiometic lifetime imaging biosensors in the meantime. © 2020 Elsevier B.V.
KeywordBiocompatibility Biomarkers Diseases Fluorescence Rare earths Smartphones Fluorescence intensities Luminescence properties Luminous properties Proportional change Ratiometric detection Ratiometric fluorescence Solubility in waters Supramolecular assemblies
PublisherElsevier B.V.
DOI10.1016/j.talanta.2020.122063
Indexed ByEI
Language英语
EI Accession Number20210209743886
EI KeywordsSupramolecular chemistry
EI Classification Number461.9.1 Immunology - 718.1 Telephone Systems and Equipment - 741.1 Light/Optics - 801.4 Physical Chemistry - 804.2 Inorganic Compounds
Citation statistics
Document Type期刊论文
Identifierhttp://ir.lzu.edu.cn/handle/262010/443805
Collection化学化工学院
Affiliation1.State Key Laboratory of Applied Organic Chemistry, Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou; 730000, China;
2.State Key Laboratory of Baiyunobo Rare Earth Resource Researches and Comprehensive Utilization, Baotou Research Institute of Rare Earths, Baotou; 014030, China;
3.Department of Laboratory Medicine, Pulmonary Hospital of Lanzhou, Lanzhou; 7380000, China
First Author AffilicationCollege of Chemistry and Chemical Engineering
Recommended Citation
GB/T 7714
Su, Pingru,Wang, Xiaoyuan,Wang, Tao,et al. Eu3+/Tb3+ supramolecular assembly hybrids for ultrasensitive and ratiometric detection of anthrax spore biomarker in water solution and actual spore samples[J]. Talanta,2021,225.
APA Su, Pingru.,Wang, Xiaoyuan.,Wang, Tao.,Feng, Xiaoxia.,Zhang, Meina.,...&Tang, Yu.(2021).Eu3+/Tb3+ supramolecular assembly hybrids for ultrasensitive and ratiometric detection of anthrax spore biomarker in water solution and actual spore samples.Talanta,225.
MLA Su, Pingru,et al."Eu3+/Tb3+ supramolecular assembly hybrids for ultrasensitive and ratiometric detection of anthrax spore biomarker in water solution and actual spore samples".Talanta 225(2021).
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