兰州大学机构库 >基础医学院
Silencing the COPB2 gene decreases the proliferation, migration and invasion of human triple-negative breast cancer cells
Wu, Wencheng1; Wang, CY(王晨昱)1; Wang, Fengxia1; Wang, Yan2; Jin, Yanling1; Luo, Jing1; Wang, M(王敏)1; Zhang, CL(张晨丽)1; Wang, Shuya1; Zhang, FF(张芳芳)1; Li, M(李敏)1,3
2021-08
Source PublicationEXPERIMENTAL AND THERAPEUTIC MEDICINE
ISSN1792-0981
Volume22Issue:2
AbstractTriple-negative breast cancer (TNBC) is highly invasive, has a high rate of recurrence and is associated with a poor clinical outcome when compared with non-TNBC due to a lack of effective and targeted treatments. The coatomer protein complex subunit beta 2 (COPB2) is upregulated in various types of malignant cancer. The present study demonstrated that COPB2 expression levels were significantly upregulated in breast carcinoma HS-578T cells (clonal cells originating from TNBC) when compared with non-TNBC MCF-7 cells. HS-578T cells also exhibited higher rates of proliferation, invasion and transendothelial migration when compared with MCF-7 cells. Moreover, it was identified that genetically silencing the COPB2 gene using a lentivirus-short hairpin RNA inhibited the proliferative, colony formation, migratory and invasive properties of the TNBC HS-578T cells. Mediation of the COPB2 silencing effect may be associated with regulating the phosphorylation of serine/threonine kinase AKT in the PI3K/AKT signaling pathway. These results suggested the importance of COPB2 in promoting the proliferation of TNBC cells and identified COPB2 as a potential novel therapeutic target.
Keywordcoatomer protein complex subunit beta 2triple-negative breast cancermigrationinvasionphosphorylated-AKT
PublisherSPANDIDOS PUBL LTD
DOI10.3892/etm.2021.10224
Indexed BySCIE
Language英语
WOS Research AreaResearch & Experimental Medicine
WOS SubjectMedicine, Research & Experimental
WOS IDWOS:000657723400001
Original Document TypeArticle
Citation statistics
Document Type期刊论文
Identifierhttp://ir.lzu.edu.cn/handle/262010/450673
Collection基础医学院
Corresponding AuthorZhang, Fangfang
Affiliation1.Lanzhou Univ, Dept Pathol, Sch Basic Med Sci, 222 South Tianshui Rd, Lanzhou 730000, Gansu, Peoples R China;
2.Lanzhou Univ, Gansu Prov Hosp, Lanzhou 730000, Gansu, Peoples R China;
3.Lanzhou Univ, Gansu Prov Key Lab Preclin Study New Drug Dev, Lanzhou 730000, Gansu, Peoples R China
First Author AffilicationSchool of Basic Medical Sciences
Corresponding Author AffilicationSchool of Basic Medical Sciences
Recommended Citation
GB/T 7714
Wu, Wencheng,Wang, Chenyu,Wang, Fengxia,et al. Silencing the COPB2 gene decreases the proliferation, migration and invasion of human triple-negative breast cancer cells[J]. EXPERIMENTAL AND THERAPEUTIC MEDICINE,2021,22(2).
APA Wu, Wencheng.,Wang, Chenyu.,Wang, Fengxia.,Wang, Yan.,Jin, Yanling.,...&Li, Min.(2021).Silencing the COPB2 gene decreases the proliferation, migration and invasion of human triple-negative breast cancer cells.EXPERIMENTAL AND THERAPEUTIC MEDICINE,22(2).
MLA Wu, Wencheng,et al."Silencing the COPB2 gene decreases the proliferation, migration and invasion of human triple-negative breast cancer cells".EXPERIMENTAL AND THERAPEUTIC MEDICINE 22.2(2021).
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