兰州大学机构库 >化学化工学院
Highly selective fluorescence probe with peptide backbone for imaging mercury ions in living cells based on aggregation-induced emission effect
Li, Yongxin1; Zhang, Yaoling2; Wang, Min3; Wang, Daojiong4; Chen, Kai4; Lin, Pengcheng3; Ge, Yushu4; Liu, WS(刘伟生)1; Wu, J(吴疆)1,4
2021-08-05
Source PublicationJournal of Hazardous Materials
ISSN03043894
Volume415
AbstractMercury is an anthropogenic toxic heavy metal found in the environment. It is highly desirable to develop a fluorescence probe that can selectively and sensitively detect mercury ions using a turn-on response. This paper reports the successful development of a peptide fluorescence probe, TP-2 (TPE-Trp-Pro-Gln-His-Glu-NH2), which uses aggregation-induced emission effects and high selectivity to detect Hg2+. After fluorescence was activated, Hg2+ was efficiently detected using the change in fluorescence intensity. The detection limit for Hg2+ in the buffer solution was 41 nM (R2 = 0.9952). Owing to its high sensitivity, high cell permeability, and low biotoxicity, the probe could perform live cell imaging under biological conditions. This study demonstrated that TP-2 can detect Hg2+ in complex biological environments. © 2021 Elsevier B.V.
KeywordAggregation-induced emissions Cell imaging Cell-based Emission effects Fluorescence probes Living cell Mercury ion Peptide backbones Peptide probe Selective fluorescence Aggregation-induced emissions Cell imaging Cell-based Emission effects Fluorescence probes Living cell Mercury ion Peptide backbones Peptide probe Selective fluorescence
PublisherElsevier B.V.
DOI10.1016/j.jhazmat.2021.125712
Indexed ByEI
Language英语
EI Accession Number20211410167571
EI KeywordsIons
EI Classification Number461.2 Biological Materials and Tissue Engineering ; 461.9 Biology ; 549.3 Nonferrous Metals and Alloys excluding Alkali and Alkaline Earth Metals ; 741.1 Light/Optics
Original Document TypeJournal article (JA)
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.lzu.edu.cn/handle/262010/451213
Collection化学化工学院
Affiliation1.Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province and State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou; 730000, China;
2.Qinghai Institute of Salt Lakes, Chinese Academy of Sciences, Xining; 810008, China;
3.Key Laboratory for Tibet Plateau Phytochemistry of Qinghai Province, College of Pharmacy, Qinghai Nationalities University, Xining; 810007, China;
4.Collaborative Innovation Center of Chemistry for Life Sciences, School of Life Sciences, University of Science and Technology of China, Hefei; 230027, China
First Author AffilicationCollege of Chemistry and Chemical Engineering
Recommended Citation
GB/T 7714
Li, Yongxin,Zhang, Yaoling,Wang, Min,et al. Highly selective fluorescence probe with peptide backbone for imaging mercury ions in living cells based on aggregation-induced emission effect[J]. Journal of Hazardous Materials,2021,415.
APA Li, Yongxin.,Zhang, Yaoling.,Wang, Min.,Wang, Daojiong.,Chen, Kai.,...&Wu, Jiang.(2021).Highly selective fluorescence probe with peptide backbone for imaging mercury ions in living cells based on aggregation-induced emission effect.Journal of Hazardous Materials,415.
MLA Li, Yongxin,et al."Highly selective fluorescence probe with peptide backbone for imaging mercury ions in living cells based on aggregation-induced emission effect".Journal of Hazardous Materials 415(2021).
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