兰州大学机构库
In vivo imaging via a red-emitting fluorescent probe to diagnosing liver cancer or drug-induced liver disease
Yang, Yuexia1; Zhang, Liang2; Li, Jiajun3; Wang, Jiemin1; Cao, Ting1; Zheng, Lei1; Cao, Yuping1; Qin, Wenwu1; Liu, Yun2
2021-07-11
Source PublicationAnalytica Chimica Acta
ISSN0003-2670
Volume1168
AbstractLeucine aminopeptidase (LAP) as an important proteolytic enzyme, has been mainly found in hepatobiliary cells, and overexpressed in hepatoma cells. Herein, a new highly selective red-emitting fluorescent probe (DCDHF-Ala) for LAP has been synthesized based on 2-dicyanomethyldiene-3-cyano-2, 5-dihydrofuran (DCDHF) as fluorophore, and alanine (Ala) as the detection group. More importantly, it's the first time to use Ala as a reactive group for LAP. DCDHF-Ala has a low detection limit (0.20 U/L), excellent water solubility and cell membrane permeability. In addition, the probe has been successfully applied to fluorescent imaging in cells and zebrafish. It's especially worth mentioning that, DCDHF-Ala has a high biosafety and enables a real-time detection of LAP levels in mice model. What's the most important is that DCDHF-Ala may be an effective tool to qualitatively monitor the upregulation of LAP induced by liver injury and liver cancer. © 2021 Elsevier B.V.
KeywordAmino acids Cells Cytology Diagnosis Fluorescence imaging Fluorescence spectroscopy Mammals Probes Dihydrofurans Fluorescent probes In-vitro In-vivo Leucine aminopeptidase Liver cancers Liver injuries Mouse imaging Red-emitting Red-emitting fluorescent probe
PublisherElsevier B.V.
DOI10.1016/j.aca.2021.338621
Indexed ByEI
Language英语
EI Accession Number20212010350344
EI KeywordsDiseases
EI Classification Number461.2 Biological Materials and Tissue Engineering ; 461.6 Medicine and Pharmacology ; 461.9 Biology ; 741.3 Optical Devices and Systems ; 746 Imaging Techniques ; 804.1 Organic Compounds ; 941.3 Optical Instruments ; 941.4 Optical Variables Measurements
Original Document TypeJournal article (JA)
Citation statistics
Document Type期刊论文
Identifierhttp://ir.lzu.edu.cn/handle/262010/451880
Collection兰州大学
Affiliation1.Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, State Key Laboratory of Applied Organic Chemistry and Key Laboratory of Special Function Materials and Structure Design (MOE), College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou; 730000, China;
2.Department of Radiology, Xinqiao Hospital, Army Medical University, Chongqing; 400037, China;
3.State Key Laboratory of Veterinary Etiological Biology and Key Laboratory of Animal Virology of Ministry of Agriculture, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Xujiaping 1, Lanzhou; Gansu Province; 730046, China
First Author AffilicationCollege of Chemistry and Chemical Engineering
Recommended Citation
GB/T 7714
Yang, Yuexia,Zhang, Liang,Li, Jiajun,et al. In vivo imaging via a red-emitting fluorescent probe to diagnosing liver cancer or drug-induced liver disease[J]. Analytica Chimica Acta,2021,1168.
APA Yang, Yuexia.,Zhang, Liang.,Li, Jiajun.,Wang, Jiemin.,Cao, Ting.,...&Liu, Yun.(2021).In vivo imaging via a red-emitting fluorescent probe to diagnosing liver cancer or drug-induced liver disease.Analytica Chimica Acta,1168.
MLA Yang, Yuexia,et al."In vivo imaging via a red-emitting fluorescent probe to diagnosing liver cancer or drug-induced liver disease".Analytica Chimica Acta 1168(2021).
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