兰州大学机构库
Biochanin A Inhibits Glioblastoma Growth via Restricting Glycolysis and Mitochondrial Oxidative Phosphorylation
Dong, Qiang1,2; Li, Qiao1; Duan, Lei1; Yin, Hang1; Wang, Xiaoqing2; Liu, Yang2; Wang, Bo1; Li, Kun1; Yao, Xuan1; Yuan, Guoqiang2; Pan, Yawen1,2
2021-07-08
Source PublicationFRONTIERS IN ONCOLOGY
ISSN2234-943X
Volume11
AbstractAbnormal metabolism serves a critical role in glioblastoma (GBM). Biochanin A (BCA), a flavonoid phenolic compound found in edible and herbal plants, has antioxidative and antitumor activities. However, it remains unclear whether BCA has an effect on energy metabolism. The aim of the present study was to evaluate the anticancer effects and molecular mechanism of the effect of BCA on energy metabolism. We observed that BCA inhibited the growth of U251 cells by the mitochondria-mediated intrinsic apoptotic pathway. BCA treatment reduced metabolic function, repressed mitochondrial membrane potential, and increased the production of reactive oxygen species (ROS) in GBM. In addition, we found that BCA decreased aerobic glycolysis by inactivation of the AKT/mTOR pathway. Taken together, the results demonstrate that treatment with BCA inhibited the proliferation of GBM by regulating metabolic reprogramming.
Keywordbiochanin A glioblastoma energy metabolism reactive oxygen species proliferation
PublisherFRONTIERS MEDIA SA
DOI10.3389/fonc.2021.652008
Indexed BySCOPUS ; SCIE
Language英语
WOS Research AreaOncology
WOS SubjectOncology
WOS IDWOS:000675596500001
Original Document TypeArticle
Citation statistics
Document Type期刊论文
Identifierhttp://ir.lzu.edu.cn/handle/262010/452310
Collection兰州大学
Affiliation1.Lanzhou Univ, Hosp 2, Dept Neurosurg, Lanzhou, Peoples R China;
2.Key Lab Neurol Gansu Prov, Lanzhou, Peoples R China
First Author AffilicationSecond Clinical School
Recommended Citation
GB/T 7714
Dong, Qiang,Li, Qiao,Duan, Lei,et al. Biochanin A Inhibits Glioblastoma Growth via Restricting Glycolysis and Mitochondrial Oxidative Phosphorylation[J]. FRONTIERS IN ONCOLOGY,2021,11.
APA Dong, Qiang.,Li, Qiao.,Duan, Lei.,Yin, Hang.,Wang, Xiaoqing.,...&Pan, Yawen.(2021).Biochanin A Inhibits Glioblastoma Growth via Restricting Glycolysis and Mitochondrial Oxidative Phosphorylation.FRONTIERS IN ONCOLOGY,11.
MLA Dong, Qiang,et al."Biochanin A Inhibits Glioblastoma Growth via Restricting Glycolysis and Mitochondrial Oxidative Phosphorylation".FRONTIERS IN ONCOLOGY 11(2021).
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