兰州大学机构库 >化学化工学院
Nor-lignans and steroidal saponins from Asparagus gobicus
Yang, CX; Huang, SS; Yang, XP; Jia, ZJ(贾忠建); Jia, ZJ (reprint author), Lanzhou Univ, Coll Chem & Chem Engn, Natl Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China.
2004-05
发表期刊PLANTA MEDICA
ISSN0032-0943
卷号70期号:5
出版者GEORG THIEME VERLAG KG
摘要From the roots of Asparagus gobicus, four new nor-lignans, 3-methoxynyasin, iso-agatharesinol, gobicusins A, B and one new steroidal saponin, 3-O-[beta-D-xylopyranosyl(1-4)-beta-D-glicopyranosyl(1 -2)-beta-D-glucopyranosyl]-(25S)-5beta-spirostan-3beta-ol (11) were isolated, together with twelve known compounds. The structures of the new compounds were established by spectroscopic methods including 2D-NMR techniques (H-1-H-1 COSY, HMBC, HMQC) and chemical transformations. Nyasol (5) and 11 exhibited remarkable in vitro cytotoxic activity against cultured HO-8910 (human ovarian carcinoma) and Bel-7402 (human hepatoma) cells With IC50 vales of 30.6 and 29.4 muM, 5.2 and 5.2 muM, respectively.
出版地STUTTGART
关键词Asparagus gobicus Asparagaceae nor-lignans steroidal saponins cytotoxic activity
学科领域Plant Sciences ; Pharmacology & Pharmacy
作者部门Lanzhou Univ, Coll Chem & Chem Engn, Natl Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China
DOI10.1055/s-2004-818974
文章类型Article
收录类别SCIE ; PubMed ; MEDLINE ; BIOSIS
语种英语
WOS记录号WOS:000221553200012
PM记录号15124091
BIOSIS记录号BIOSIS:PREV200400314353
第一机构
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文献类型期刊论文
条目标识符http://ir.lzu.edu.cn/handle/262010/78625
Collection化学化工学院
通讯作者Jia, ZJ (reprint author), Lanzhou Univ, Coll Chem & Chem Engn, Natl Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China.
Recommended Citation:
GB/T 7714
Yang, CX,Huang, SS,Yang, XP,et al. Nor-lignans and steroidal saponins from Asparagus gobicus[J]. PLANTA MEDICA,2004,70(5).
APA Yang, CX,Huang, SS,Yang, XP,Jia, ZJ,&Jia, ZJ .(2004).Nor-lignans and steroidal saponins from Asparagus gobicus.PLANTA MEDICA,70(5).
MLA Yang, CX,et al."Nor-lignans and steroidal saponins from Asparagus gobicus".PLANTA MEDICA 70.5(2004).
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