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兰州大学机构库  > 化学化工学院  > 期刊论文
题名: Nor-lignans and steroidal saponins from Asparagus gobicus
作者: Yang, CX; Huang, SS; Yang, XP; Jia, ZJ(贾忠建)
收录类别: SCIE ; PubMed ; MEDLINE ; BIOSIS
出版日期: 2004-05
刊名: PLANTA MEDICA
卷号: 70, 期号:5
出版者: GEORG THIEME VERLAG KG
出版地: STUTTGART
英文摘要: From the roots of Asparagus gobicus, four new nor-lignans, 3-methoxynyasin, iso-agatharesinol, gobicusins A, B and one new steroidal saponin, 3-O-[beta-D-xylopyranosyl(1-4)-beta-D-glicopyranosyl(1 -2)-beta-D-glucopyranosyl]-(25S)-5beta-spirostan-3beta-ol (11) were isolated, together with twelve known compounds. The structures of the new compounds were established by spectroscopic methods including 2D-NMR techniques (H-1-H-1 COSY, HMBC, HMQC) and chemical transformations. Nyasol (5) and 11 exhibited remarkable in vitro cytotoxic activity against cultured HO-8910 (human ovarian carcinoma) and Bel-7402 (human hepatoma) cells With IC50 vales of 30.6 and 29.4 muM, 5.2 and 5.2 muM, respectively.
关键词: Asparagus gobicus ; Asparagaceae ; nor-lignans ; steroidal saponins ; cytotoxic activity
作者部门: Lanzhou Univ, Coll Chem & Chem Engn, Natl Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China
通讯作者: Jia, ZJ (reprint author), Lanzhou Univ, Coll Chem & Chem Engn, Natl Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China.
学科分类: Plant Sciences;Pharmacology & Pharmacy
文章类型: Article
语种: 英语
DOI: 10.1055/s-2004-818974
ISSN号: 0032-0943
WOS记录号: WOS:000221553200012
PM记录号: 15124091
BIOSIS记录号: BIOSIS:PREV200400314353
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内容类型: 期刊论文
URI标识: http://ir.lzu.edu.cn/handle/262010/78625
Appears in Collections:化学化工学院_期刊论文

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Yang, CX; Huang, SS; Yang, XP; Jia, ZJ.Nor-lignans and steroidal saponins from Asparagus gobicus,PLANTA MEDICA,2004,70(5):
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