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题名: Determination of dissociation constants of trimethoprim and sulfamethoxazole and their concentrations in co-trimoxazole tablets by capillary zone electrophoresis
其他题名: 毛细管区带电泳法测定甲氧苄胺嘧啶和磺胺甲基异—唑的离解常数及其在复方新诺明中的含量
作者: Li, QF; Zhang, HY; Wang, HW; Chen, XG(陈兴国); Hu, ZD(胡之德)
收录类别: SCIE ; CSCD
出版日期: 2000-07
刊名: CHINESE JOURNAL OF ANALYTICAL CHEMISTRY
卷号: 28, 期号:7, 页码:793-797
期刊主办单位: 中国化学会 ; 中国科学院长春应用化学研究所
出版者: FENXI HUAXUE
出版地: CHANGCHUN
中文摘要: 报道了利用 30 mml/L HAc-NaAc为缓冲液测定复方新诺明中甲氧苄胺嘧啶(TMP)和磺胺甲基异噁唑(SMZ)的离解常数及含量的毛细管区带电泳(CZE)方法。该方法具有简便、快速、准确等特点。测得TMP和SMZ的pKa分别为6.60和5.90。其平均回收率分别为101.5%和99.6%,最低检出限为0.48 mg/L和0.028 mg/L,RSD为1.26%和1.12%。
英文摘要: A rapid and reliable capillary zone electrophoresis method has been established for the determination of trimethoprim and sufamethoxazole in co-trimoxazole tablets as well as their dissociation constants. With 30 mmol/L acetate as buffer electrolyte (pH = 5.55), the two components in cotrimoxazole tablets were separated, and ethanol used as solvent in analysis procedure did not interfere with their determination. The relative standard deviation for trimethoprim and sufamethoxazole was 1.3% and 1.1%, respectively. The detection limit was 0.48 mg/L for trimethoprim and 0. 028 mg/L for sufamethoxazole. The recovery of trimethoprim was 101.5% and that of sufamethoxazole was 99.6%. The contents of trimethoprim and sufamethoxazole obtained by the method were in good agreement with the nominal values. It was that the capillary electrophoresis method could be employed conveniently to determine the dissociation constants of trimethoprim and sulfamethoxazole. The dissociation constant of trimethoprim and sulfamethoxazole obtained from capillary electrophoresis method was 6.60 and 5.90, respectively. The determined dissociation constants were closed to the values appeared in some common physical and chemical handbooks.
关键词: capillary zone electrophoresis ; co-trimoxazole tablets ; trimethoprim ; sulfamethoxazole ; dissociation constant ; 毛细管区带电泳 ; 复方新诺明 ; 甲氧苄胺嘧啶 ; 磺胺甲基异噁唑 ; 离解常数
作者部门: Lanzhou Univ, Dept Chem, Lanzhou 730000, Peoples R China ; Lanzhou Univ, Dept Biol, Lanzhou 730000, Peoples R China
通讯作者: Hu, ZD (reprint author), Lanzhou Univ, Dept Chem, Lanzhou 730000, Peoples R China.
学科分类: Chemistry
文章类型: Article
所属项目编号: 国家自然科学基金!(No.2945194和29675007) ; 中国博士后科研基金
所属项目名称: 国家自然科学基金项目 ; 中国博士后科学基金 
项目资助者: NSFC ; CPSF
语种: 中文
ISSN号: 0253-3820
WOS记录号: WOS:000088489300001
CSCD记录号: CSCD:586729
第一机构:
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内容类型: 期刊论文
URI标识: http://ir.lzu.edu.cn/handle/262010/80792
Appears in Collections:化学化工学院_期刊论文

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Recommended Citation:
Li, QF; Zhang, HY; Wang, HW; Chen, XG; Hu, ZD.Determination of dissociation constants of trimethoprim and sulfamethoxazole and their concentrations in co-trimoxazole tablets by capillary zone electrophoresis,CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,2000,28(7):
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