兰州大学机构库

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Intramolecular cyclization of the antimicrobial peptide Polybia-MPI with triazole stapling: influence on stability and bioactivity 期刊论文
JOURNAL OF PEPTIDE SCIENCE, 2017, 卷号: 23, 期号: 18, 页码: 824-832
Authors:  Liu, BJ;  Zhang, W;  Gou, SH;  Huang, HF;  Yao, J;  Yang, ZB;  Liu, H;  Zhong, C;  Liu, BY;  Ni, JM...Liu, BJ;  Zhang, W;  Gou, SH;  Huang, HF;  Yao, J;  Yang, ZB;  Liu, H;  Zhong, C;  Liu, BY;  Ni, JM;  Wang, R;  Wang, R (reprint author), Lanzhou Univ, Key Lab Preclin Study New Drugs Gansu Prov, Sch Basic Med Sci, Lanzhou 730000, Peoples R China.
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antimicrobial peptides  intramolecular cyclization  click chemistry  stability  antimicrobial activity  secondary structure  mechanism of action  
Novel antimicrobial peptide CPF-C1 analogs with superior stabilities and activities against multidrug-resistant bacteria 期刊论文
CHEMICAL BIOLOGY & DRUG DESIGN, 2017, 卷号: 90, 期号: 3, 页码: 690-702
Authors:  Xie, JQ;  Zhao, Q;  Li, SS;  Yan, ZB;  Li, J;  Li, Y;  Mou, LY;  Zhang, BZ;  Yang, WL;  Miao, XK...Xie, JQ;  Zhao, Q;  Li, SS;  Yan, ZB;  Li, J;  Li, Y;  Mou, LY;  Zhang, BZ;  Yang, WL;  Miao, XK;  Jiang, XX;  Wang, R;  Wang, R (reprint author), Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou, Guangdong, Peoples R China.
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analogs  antibiofilm  antimicrobial peptides  multidrug-resistant bacteria  stability  
Peripheral and central sites of action for anti-allodynic activity induced by the bifunctional opioid/NPFF receptors agonist BN-9 in inflammatory pain model 期刊论文
EUROPEAN JOURNAL OF PHARMACOLOGY, 2017, 卷号: 813, 期号: 2, 页码: 122-129
Authors:  Zhang, R;  Xu, B;  Zhang, MN;  Zhang, T;  Wang, ZL;  Zhao, G;  Zhao, GH;  Li, N;  Fang, Q;  Wang, R...Zhang, R;  Xu, B;  Zhang, MN;  Zhang, T;  Wang, ZL;  Zhao, G;  Zhao, GH;  Li, N;  Fang, Q;  Wang, R;  Wang, R (reprint author), Lanzhou Univ, Key Lab Preclin Study New Drugs Gansu Prov, Sch Basic Med Sci, 199 Donggang West Rd, Lanzhou 730000, Gansu, Peoples R China.
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BN-9  Opioid  Neuropeptide FF  Bifunctional agonist  Inflammatory pain  
MEL-N16: A Series of Novel Endomorphin Analogs with Good Analgesic Activity and a Favorable Side Effect Profile 期刊论文
ACS CHEMICAL NEUROSCIENCE, 2017, 卷号: 8, 期号: 17, 页码: 2180-2193
Authors:  Liu, X;  Zhao, L;  Wang, Y;  Zhou, JJ;  Wang, D;  Zhang, YX;  Zhang, XH;  Wang, ZJ;  Yang, DX;  Mou, LY...Liu, X;  Zhao, L;  Wang, Y;  Zhou, JJ;  Wang, D;  Zhang, YX;  Zhang, XH;  Wang, ZJ;  Yang, DX;  Mou, LY;  Wang, R;  Wang, R (reprint author), Lanzhou Univ, Sch Basic Med Sci, Key Lab Preclin Study New Drugs Gansu Prov, 199 Donggang West Rd, Lanzhou 730000, Gansu, Peoples R China.
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antinociception  blood-brain barrier  endomorphin  side effect  stability  opioid peptide  
Sulforaphane increases Nrf2 expression and protects alveolar epithelial cells against injury caused by cigarette smoke extract 期刊论文
MOLECULAR MEDICINE REPORTS, 2017, 卷号: 16, 期号: 4, 页码: 1241-1247
Authors:  Jiao, ZX;  Chang, JC;  Li, J;  Nie, DM;  Cui, HJ;  Guo, DF;  Jiao, ZX (reprint author), Lanzhou Univ, Sch Basic Med Sci, Res Inst Pathol, 199 West Donggang Rd, Lanzhou 730000, Gansu, Peoples R China.
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cigarette smoke extract  alveolar epithelial cells  sulforaphane  nuclear factor erythroid 2 like 2  
Intrahippocampal injection of Cortistatin-14 impairs recognition memory consolidation in mice through activation of sst(2), ghrelin and GABA(A/B) receptors 期刊论文
BRAIN RESEARCH, 2017, 卷号: 1666, 期号: 2, 页码: 38-47
Authors:  Jiang, JH;  Peng, YL;  He, Z;  Wei, LJ;  Jin, WD;  Wang, XL;  Chang, M;  Chang, M (reprint author), Lanzhou Univ, Key Lab Preclin Study New Drugs Gansu Prov, Sch Life Sci, Inst Biochem & Mol Biol, Lanzhou 730000, Peoples R China.
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Cortistatin-14  Memory impairment  Hippocampus  SST receptors  Ghrelin receptor  GABA(A/B) receptors  
Pharmacological characterization of rat VD-hemopressin(alpha), an alpha-hemoglobin-derived peptide exhibiting cannabinoid agonist-like effects in mice 期刊论文
NEUROPEPTIDES, 2017, 卷号: 63, 期号: 9, 页码: 83-90
Authors:  Zheng, T;  Zhang, T;  Zhang, R;  Wang, ZL;  Han, ZL;  Li, N;  Li, XH;  Zhang, MN;  Xu, B;  Yang, XL...Zheng, T;  Zhang, T;  Zhang, R;  Wang, ZL;  Han, ZL;  Li, N;  Li, XH;  Zhang, MN;  Xu, B;  Yang, XL;  Fang, Q;  Wang, R;  Wang, R (reprint author), Lanzhou Univ, Sch Basic Med Sci, Key Lab Preclin Study New Drugs Gansu Prov, 199 Donggang West Rd, Lanzhou 730000, Gansu, Peoples R China.
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(r)VD-hemopressin(alpha)  Cannabinoid  Neurite outgrowth  Antinociception  Hypothermia  Hypoactivity  Mice  
Structure-Based Optimization of Multifunctional Agonists for Opioid and Neuropeptide FF Receptors with Potent Nontolerance Forming Analgesic Activities 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2016, 卷号: 59, 期号: 22, 页码: 10198-10208
Authors:  Wang, ZL;  Pan, JX;  Song, JJ;  Tang, HH;  Yu, HP;  Li, XH;  Li, N;  Zhang, T;  Zhang, R;  Zhang, MN...Wang, ZL;  Pan, JX;  Song, JJ;  Tang, HH;  Yu, HP;  Li, XH;  Li, N;  Zhang, T;  Zhang, R;  Zhang, MN;  Xu, B;  Fang, Q;  Wang, R(王锐);  Wang, R (reprint author), Lanzhou Univ, Sch Basic Med Sci, Key Lab Preclin Study New Drugs Gansu Prov, 199 Donggang West Rd, Lanzhou 730000, Peoples R China.
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Pharmacological characterization of EN-9, a novel chimeric peptide of endomorphin-2 and neuropeptide FF that produces potent antinociceptive activity and limited tolerance 期刊论文
NEUROPHARMACOLOGY, 2016, 卷号: 108, 页码: 364-372
Authors:  Wang, ZL;  Li, N;  Wang, P;  Tang, HH;  Han, ZL;  Song, JJ;  Li, XH;  Yu, HP;  Zhang, T;  Zhang, R...Wang, ZL;  Li, N;  Wang, P;  Tang, HH;  Han, ZL;  Song, JJ;  Li, XH;  Yu, HP;  Zhang, T;  Zhang, R;  Xu, B;  Zhang, MN;  Fang, Q(方泉);  Wang, R(王锐);  Wang, R (reprint author), Lanzhou Univ, Sch Basic Med Sci, Key Lab Preclin Study New Drugs Gansu Prov, 199 Donggang West Rd, Lanzhou 730000, Peoples R China.
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Chimeric peptide  Endomorphin-2  Neuropeptide FF  Opioid  Antinociception  Non-tolerance  
Enhanced autophagy reveals vulnerability of P-gp mediated epirubicin resistance in triple negative breast cancer cells 期刊论文
APOPTOSIS, 2016, 卷号: 21, 期号: 4, 页码: 473-488
Authors:  Zhang, LH;  Yang, AJ;  Wang, M;  Liu, W;  Wang, CY;  Xie, XF;  Chen, X;  Dong, JF;  Li, M;  Li, M (reprint author), Lanzhou Univ, Sch Basic Med Sci, Inst Integrated Tradit Chinese & Western Med, Lanzhou 730000, Gansu, Peoples R China....Zhang, LH;  Yang, AJ;  Wang, M;  Liu, W;  Wang, CY;  Xie, XF;  Chen, X;  Dong, JF;  Li, M;  Li, M (reprint author), Lanzhou Univ, Sch Basic Med Sci, Inst Integrated Tradit Chinese & Western Med, Lanzhou 730000, Gansu, Peoples R China.;  Li, M (reprint author), Lanzhou Univ, Sch Basic Med Sci, Inst Pathol, 199 West Donggang Rd6, Lanzhou 730000, Gansu, Peoples R China.;  Li, M (reprint author), Lanzhou Univ, Key Lab Preclin Study New Drugs Gansu Prov, Lanzhou 730000, Gansu, Peoples R China.
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Autophagy  P-gp  NF-kappa B  Epirubicin  Chemotherapy resistance  Triple negative breast cancer