兰州大学机构库

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Intramolecular cyclization of the antimicrobial peptide Polybia-MPI with triazole stapling: influence on stability and bioactivity 期刊论文
JOURNAL OF PEPTIDE SCIENCE, 2017, 卷号: 23, 期号: 18, 页码: 824-832
Authors:  Liu, BJ;  Zhang, W;  Gou, SH;  Huang, HF;  Yao, J;  Yang, ZB;  Liu, H;  Zhong, C;  Liu, BY;  Ni, JM...Liu, BJ;  Zhang, W;  Gou, SH;  Huang, HF;  Yao, J;  Yang, ZB;  Liu, H;  Zhong, C;  Liu, BY;  Ni, JM;  Wang, R;  Wang, R (reprint author), Lanzhou Univ, Key Lab Preclin Study New Drugs Gansu Prov, Sch Basic Med Sci, Lanzhou 730000, Peoples R China.
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antimicrobial peptides  intramolecular cyclization  click chemistry  stability  antimicrobial activity  secondary structure  mechanism of action  
Novel antimicrobial peptide CPF-C1 analogs with superior stabilities and activities against multidrug-resistant bacteria 期刊论文
CHEMICAL BIOLOGY & DRUG DESIGN, 2017, 卷号: 90, 期号: 3, 页码: 690-702
Authors:  Xie, JQ;  Zhao, Q;  Li, SS;  Yan, ZB;  Li, J;  Li, Y;  Mou, LY;  Zhang, BZ;  Yang, WL;  Miao, XK...Xie, JQ;  Zhao, Q;  Li, SS;  Yan, ZB;  Li, J;  Li, Y;  Mou, LY;  Zhang, BZ;  Yang, WL;  Miao, XK;  Jiang, XX;  Wang, R;  Wang, R (reprint author), Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou, Guangdong, Peoples R China.
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analogs  antibiofilm  antimicrobial peptides  multidrug-resistant bacteria  stability  
Antimicrobial activity and stability of protonectin with D-amino acid substitutions 期刊论文
JOURNAL OF PEPTIDE SCIENCE, 2017, 卷号: 23, 期号: 5, 页码: 392-402
Authors:  Qiu, S;  Zhu, RR;  Zhao, YY;  An, XP;  Jia, FJ;  Peng, JX;  Ma, ZL;  Zhu, YY;  Wang, JY;  Su, JH...Qiu, S;  Zhu, RR;  Zhao, YY;  An, XP;  Jia, FJ;  Peng, JX;  Ma, ZL;  Zhu, YY;  Wang, JY;  Su, JH;  Wang, QJ;  Wang, HL;  Li, Y;  Wang, KR;  Yan, WJ;  Wang, R(王锐);  Wang, R (reprint author), Lanzhou Univ, Sch Basic Med Sci, Lanzhou, Peoples R China.
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antimicrobial peptides  protonectin  stability  D-amino acid substitution  
Alleviative effect of ciliary neurotrophic factor analogue on high fat-induced hepatic steatosis is partially independent of the central regulation 期刊论文
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 2017, 卷号: 44, 期号: 3, 页码: 395-402
Authors:  Cui, MX;  Yang, LN;  Wang, XX;  Wang, L;  Li, RL;  Han, W;  Wu, YJ(吴勇杰);  Wu, YJ (reprint author), Lanzhou Univ, Sch Basic Med Sci, Inst Pharmacol, Lanzhou, Peoples R China.
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ciliary neurotrophic factor  HepG2 cell  high-fat diet  non-alcoholic fatty liver diseases  rat  
Catalytic Asymmetric Inverse-Electron-Demand 1,3-Dipolar Cycloaddition of C,N-Cyclic Azomethine Imines with Azlactones: Access to Chiral Tricyclic Tetrahydroisoquinolines 期刊论文
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2016, 卷号: 55, 期号: 28, 页码: 8100-8103
Authors:  Liu, XH;  Wang, YJ;  Yang, DX;  Zhang, JL;  Liu, DS;  Su, W;  Su, W (reprint author), Chinese Acad Sci, Shenzhen Inst Adv Technol, Inst Biomed & Biotechnol, Guangdong Key Lab Nanomed, Shenzhen 518055, Guangdong, Peoples R China.;  Liu, DS (reprint author), Tsinghua Univ, Dept Chem, Minist Educ, Key Lab Organ Optoelect & Mol Engn, Beijing 100084, Peoples R China.
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cycloaddition  hydrogen bonds  lactones  organocatalysis  synthetic methods  
Mg-II-Mediated Catalytic Asymmetric Dearomatization (CADA) Reaction of beta-Naphthols with Dialkyl Acetylenedicarboxylates 期刊论文
CHEMISTRY-A EUROPEAN JOURNAL, 2016, 卷号: 22, 期号: 25, 页码: 8483-8487
Authors:  Wang, LQ;  Yang, DX;  Li, D;  Wang, PX;  Wang, KZ;  Wang, J;  Jiang, XX;  Wang, R(王锐);  Wang, R (reprint author), Lanzhou Univ, Key Lab Preclin Study New Drugs Gansu Prov, Sch Basic Med Sci, Lanzhou 730000, Peoples R China.;  Jiang, XX (reprint author), Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R China....Wang, LQ;  Yang, DX;  Li, D;  Wang, PX;  Wang, KZ;  Wang, J;  Jiang, XX;  Wang, R(王锐);  Wang, R (reprint author), Lanzhou Univ, Key Lab Preclin Study New Drugs Gansu Prov, Sch Basic Med Sci, Lanzhou 730000, Peoples R China.;  Jiang, XX (reprint author), Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R China.
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cyclization  dearomatization  fluorine  magnesium  naphthols  
Catalytic Asymmetric Ring-Opening Reactions of Aziridines with 3-Aryl-Oxindoles 期刊论文
CHEMISTRY-AN ASIAN JOURNAL, 2016, 卷号: 11, 期号: 5, 页码: 691-695
Authors:  Wang, LQ;  Li, D;  Yang, DX;  Wang, KZ;  Wang, J;  Wang, PX;  Su, W;  Wang, R(王锐);  Wang, R (reprint author), Lanzhou Univ, Sch Basic Med Sci, Key Lab Preclin Study New Drugs Gansu Prov, Lanzhou 730000, Peoples R China.;  Su, W (reprint author), Chinese Acad Sci, Shenzhen Inst Adv Technol, Inst Biomed & Biotechnol, Guangdong Key Lab Nanomed, Shenzhen 518055, Guangdong, Peoples R China....Wang, LQ;  Li, D;  Yang, DX;  Wang, KZ;  Wang, J;  Wang, PX;  Su, W;  Wang, R(王锐);  Wang, R (reprint author), Lanzhou Univ, Sch Basic Med Sci, Key Lab Preclin Study New Drugs Gansu Prov, Lanzhou 730000, Peoples R China.;  Su, W (reprint author), Chinese Acad Sci, Shenzhen Inst Adv Technol, Inst Biomed & Biotechnol, Guangdong Key Lab Nanomed, Shenzhen 518055, Guangdong, Peoples R China.;  Wang, R (reprint author), Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, State Key Lab Chirosci, Kowloon, Hong Kong, Peoples R China.
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aziridines  3,3 '-fluorinated-binol  magnesium catalysis  oxindoles  ring-opening reactions  
MgII-Catalyzed Desymmetrization Reaction of meso-Aziridines with Hydroxylamines: Synthesis of Novel Chiral 1,2-Diamine Skeletons 期刊论文
CHEMISTRY-A EUROPEAN JOURNAL, 2016, 卷号: 22, 期号: 48, 页码: 17141-17144
Authors:  Li, Dan;  Yang, Dongxu;  Wang, Linqing;  Liu, Xihong;  Jiang, Xianxing;  Wang, R(王锐);  Yang, DX;  Wang, R (reprint author), Lanzhou Univ, Key Lab Preclin Study New Drugs Gansu Prov, Lanzhou 730000, Peoples R China.;  Jiang, XX (reprint author), Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R China.
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asymmetric synthesis  diamines  hydroxylamine  magnesium  oxazoline  
Catalytic Asymmetric Michael Reaction of 5H-Oxazol-4-Ones with alpha,beta-Unsaturated Acyl Imidazoles 期刊论文
CHEMISTRY-A EUROPEAN JOURNAL, 2015, 卷号: 21, 期号: 48, 页码: 17234-17238
Authors:  Zhang, BZ(张邦治);  Han, FX;  Wang, LQ;  Li, D;  Yang, DX;  Yang, XL;  Yang, JX;  Li, XF;  Zhao, DP;  Wang, R(王锐)...Zhang, BZ(张邦治);  Han, FX;  Wang, LQ;  Li, D;  Yang, DX;  Yang, XL;  Yang, JX;  Li, XF;  Zhao, DP;  Wang, R(王锐);  Wang, R (reprint author), Lanzhou Univ, Sch Basic Med Sci, Sch Life Sci, Key Lab Preclin Study New Drugs Gansu Prov, Lanzhou 730000, Peoples R China.
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asymmetric synthesis  heterocycles  ligand design  Michael addition  zinc  
Antimicrobial activities and action mechanism studies of transportan 10 and its analogues against multidrug-resistant bacteria 会议论文
JOURNAL OF PEPTIDE SCIENCE, Datong City, PEOPLES R CHINA, JUN 30-JUL 04, 2014
Authors:  Xie, JQ;  Gou, YM;  Zhao, Q;  Li, SS;  Zhang, W;  Song, JJ;  Mou, LY;  Li, JY;  Wang, KR;  Zhang, BZ...Xie, JQ;  Gou, YM;  Zhao, Q;  Li, SS;  Zhang, W;  Song, JJ;  Mou, LY;  Li, JY;  Wang, KR;  Zhang, BZ;  Yang, WL;  Wang, R(王锐);  Wang, R (reprint author), Lanzhou Univ, Sch Basic Med Sci, Key Lab Preclin Study New Drugs Gansu Prov, 222 Tian Shui South Rd, Lanzhou 730000, Peoples R China.
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Multidrug-resistant Bacteria  Cell-penetrating Peptides  Transportan 10  Structure-activity Relationships  Action Mechanism