兰州大学机构库
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Endomorphin-1 analogs containing alpha-methyl-beta-amino acids exhibit potent analgesic activity after peripheral administration 期刊论文
ORGANIC & BIOMOLECULAR CHEMISTRY, 2017, 卷号: 12, 期号: 23, 页码: 4951-4955
Authors:  Wang, Y;  Yang, JX;  Liu, X;  Zhao, L;  Yang, DX;  Zhou, JJ;  Wang, D;  Mou, LY;  Wang, R(王锐);  Wang, R (reprint author), Lanzhou Univ, Key Lab Preclin Study New Drugs Gansu Prov, Dept Pharmacol, Inst Biochem & Mol Biol,Sch Basic Med Sci, Lanzhou 730000, Peoples R China....Wang, Y;  Yang, JX;  Liu, X;  Zhao, L;  Yang, DX;  Zhou, JJ;  Wang, D;  Mou, LY;  Wang, R(王锐);  Wang, R (reprint author), Lanzhou Univ, Key Lab Preclin Study New Drugs Gansu Prov, Dept Pharmacol, Inst Biochem & Mol Biol,Sch Basic Med Sci, Lanzhou 730000, Peoples R China.
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Magnesium Catalysis Mediated Tetrazoles in Desymmetrization Reaction of Aziridines 期刊论文
ORGANIC LETTERS, 2017, 卷号: 19, 期号: 12, 页码: 3211-3214
Authors:  Li, D;  Wang, KZ;  Wang, LQ;  Wang, Y;  Wang, PX;  Liu, X;  Yang, DX;  Wang, R(王锐);  Wang, R (reprint author), Lanzhou Univ, Key Lab Preclin Study New Drugs Gansu Prov, Lanzhou 730000, Peoples R China.
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An Efficient Nickel-Catalyzed Asymmetric Oxazole-Forming Ugi-Type Reaction for the Synthesis of Chiral Aryl-Substituted THIQ Rings 期刊论文
CHEMISTRY-A EUROPEAN JOURNAL, 2017, 卷号: 23, 期号: 29, 页码: 6974-6978
Authors:  Li, D;  Yang, DX;  Wang, LQ;  Liu, XH;  Wang, KZ;  Wang, J;  Wang, PX;  Liu, YY;  Zhu, HY;  Wang, R(王锐)...Li, D;  Yang, DX;  Wang, LQ;  Liu, XH;  Wang, KZ;  Wang, J;  Wang, PX;  Liu, YY;  Zhu, HY;  Wang, R(王锐);  Wang, R (reprint author), Lanzhou Univ, Key Lab Preclin Study New Drugs Gansu Prov, Lanzhou 730000, Peoples R China.;  Wang, R (reprint author), Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, State Key Lab Chirosci, Kowloon, Hong Kong, Peoples R China.
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chirality  nickel  oxazole  tetrahydroquinoline  ugi reaction  
Efficient Catalytic Kinetic Resolution of Spiro-epoxyoxindoles with Concomitant Asymmetric Friedel-Crafts Alkylation of Indoles 期刊论文
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2017, 卷号: 56, 期号: 19, 页码: 5332-5335
Authors:  Zhu, GM;  Bao, GJ;  Li, YP;  Sun, WS(孙旺盛);  Li, J;  Hong, L;  Wang, R(王锐);  Hong, L (reprint author), Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R China.;  Wang, R (reprint author), Lanzhou Univ, Key Lab Preclin Study New Drugs Gansu Prov, Lanzhou 730000, Peoples R China.
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asymmetric catalysis  alkylation  kinetic resolution  organocatalysis  spiro-compounds  
Structure-constrained endomorphin analogs display differential antinociceptive mechanisms in mice after spinal administration 期刊论文
PEPTIDES, 2017, 卷号: 91, 页码: 40-48
Authors:  Wang, Y;  Zhou, JJ;  Liu, X;  Zhao, L;  Wang, ZJ;  Zhang, XH;  Wang, KZ;  Wang, LQ;  Wang, R(王锐);  Wang, R (reprint author), Lanzhou Univ, Sch Basic Med Sci, Key Lab Preclin Study New Drugs Gansu Prov, 199 Donggang West Rd, Lanzhou 730000, Peoples R China....Wang, Y;  Zhou, JJ;  Liu, X;  Zhao, L;  Wang, ZJ;  Zhang, XH;  Wang, KZ;  Wang, LQ;  Wang, R(王锐);  Wang, R (reprint author), Lanzhou Univ, Sch Basic Med Sci, Key Lab Preclin Study New Drugs Gansu Prov, 199 Donggang West Rd, Lanzhou 730000, Peoples R China.
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Spinal antinociception  Endomorphin  Dynorphin  Antagonist  Antibody  
Design of novel antimicrobial peptide dimer analogues with enhanced antimicrobial activity in vitro and in vivo by intermolecular triazole bridge strategy 期刊论文
PEPTIDES, 2017, 卷号: 88, 页码: 115-125
Authors:  Liu, BJ;  Huang, HF;  Yang, ZB;  Liu, BY;  Gou, SH;  Zhong, C;  Han, XF;  Zhang, Y;  Ni, JM;  Wang, R(王锐)...Liu, BJ;  Huang, HF;  Yang, ZB;  Liu, BY;  Gou, SH;  Zhong, C;  Han, XF;  Zhang, Y;  Ni, JM;  Wang, R(王锐);  Liu, BJ (reprint author), Lanzhou Univ, Sch Basic Med Sci, Key Lab Preclin Study New Drugs Gansu Prov, Lanzhou 730000, Peoples R China.;  Liu, BJ (reprint author), Lanzhou Univ, Sch Pharm, Lanzhou 730000, Peoples R China.
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Click chemistry  Dimer analogues  Antimicrobial activity  alpha Helical structure  Drug resistance  
Activation of NPFF2 receptor stimulates neurite outgrowth in Neuro 2A cells through activation of ERK signaling pathway 期刊论文
PEPTIDES, 2016, 卷号: 86, 页码: 24-32
Authors:  Yu, HP;  Zhang, N;  Zhang, T;  Wang, ZL;  Li, N;  Tang, HH;  Zhang, R;  Zhang, MN;  Xu, BA;  Fang, Q...Yu, HP;  Zhang, N;  Zhang, T;  Wang, ZL;  Li, N;  Tang, HH;  Zhang, R;  Zhang, MN;  Xu, BA;  Fang, Q;  Wang, R(王锐);  Wang, R (reprint author), Lanzhou Univ, Sch Basic Med Sci, Key Lab Preclin Study New Drugs Gansu Prov, 199 Donggang West Rd, Lanzhou 730000, Peoples R China.
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NPFF2 receptor  Neurite outgrowth  Neuro 2A cells  MEK/ERK signaling pathway  
Structure-Based Optimization of Multifunctional Agonists for Opioid and Neuropeptide FF Receptors with Potent Nontolerance Forming Analgesic Activities 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2016, 卷号: 59, 期号: 22, 页码: 10198-10208
Authors:  Wang, ZL;  Pan, JX;  Song, JJ;  Tang, HH;  Yu, HP;  Li, XH;  Li, N;  Zhang, T;  Zhang, R;  Zhang, MN...Wang, ZL;  Pan, JX;  Song, JJ;  Tang, HH;  Yu, HP;  Li, XH;  Li, N;  Zhang, T;  Zhang, R;  Zhang, MN;  Xu, B;  Fang, Q;  Wang, R(王锐);  Wang, R (reprint author), Lanzhou Univ, Sch Basic Med Sci, Key Lab Preclin Study New Drugs Gansu Prov, 199 Donggang West Rd, Lanzhou 730000, Peoples R China.
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Chiral Phosphoric Acid Catalyzed Asymmetric Oxidative Dearomatization of Naphthols with Quinones 期刊论文
ORGANIC LETTERS, 2016, 卷号: 18, 期号: 20, 页码: 5288-5291
Authors:  Zhu, GM;  Bao, GJ;  Li, YP;  Yang, JX;  Sun, WS(孙旺盛);  Li, J;  Hong, L;  Wang, R(王锐);  Wang, R (reprint author), Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R China.;  Wang, R (reprint author), Lanzhou Univ, Key Lab Preclin Study New Drugs Gansu Prov, Lanzhou 730000, Peoples R China....Zhu, GM;  Bao, GJ;  Li, YP;  Yang, JX;  Sun, WS(孙旺盛);  Li, J;  Hong, L;  Wang, R(王锐);  Wang, R (reprint author), Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R China.;  Wang, R (reprint author), Lanzhou Univ, Key Lab Preclin Study New Drugs Gansu Prov, Lanzhou 730000, Peoples R China.
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Sodium Iodide/Hydrogen Peroxide-Mediated Oxidation/Lactonization for the Construction of Spirocyclic Oxindole-Lactones 期刊论文
ADVANCED SYNTHESIS & CATALYSIS, 2016, 卷号: 358, 期号: 18, 页码: 2873-2877
Authors:  Li, GF;  Huang, LW;  Xu, JC;  Sun, WS(孙旺盛);  Xie, JQ;  Hong, L;  Wang, R(王锐);  Wang, R (reprint author), Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R China.;  Wang, R (reprint author), Lanzhou Univ, Key Lab Preclin Study New Drugs Gansu Prov, Lanzhou 730000, Peoples R China.
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hydrogen peroxide  indolepropionic acids  oxidation  sodium iodide  spirocyclic oxindole-lactones