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The oxidation metabolites of endomorphin 1 and its fragments induced by free radicals
Gong, P; Chen, FX; Zhao, QY; Ma, GF; Wang, R(王锐); Wang, R (reprint author), Lanzhou Univ, Sch Life Sci, Key Lab Preclinied Study New Drugs Gansu Prov, Sch Basic Med Sci,Inst Biochem & Mol Biol, Lanzhou 730000, Peoples R China.
2009-05
Source PublicationJOURNAL OF PEPTIDE SCIENCE   Impact Factor & Quartile
ISSN1075-2617
Volume15Issue:5Pages:337-344
AbstractEndomorphin 1 (EM1), an endogenous mu-opioid receptor agonist, acts as a free radical scavenger in vitro and an antioxidant in vivo. The modification of EM1 by ROS and the properties of the OM attracted our attention. In vitro assays were performed via RP-HPLC, spectrophotometric measurements, EPR and amino acid analysis, Schmorl's reaction to define the formation of melanin-like compounds transformed from EM1, collectively named EM1-melanin and by solubility assay, radioligand-binding assay, NADH oxidation, superoxide anion scavenging assay to study some physical and chemical properties of EM1-melanin. Possible pathways of the formation of EM1-melanin were proposed. Copyright (C) 2009 European Peptide Society and John Wiley & Sons, Ltd.
Keywordendomorphin 1 ROS EM1-melanin oxidative metabolite
Subject AreaBiochemistry & Molecular Biology ; Chemistry
PublisherWILEY
DOI10.1002/psc.1116
Publication PlaceHOBOKEN
Indexed BySCIE ; PubMed ; MEDLINE ; BIOSIS
Language英语
First Inst
Funding Project国家自然科学基金项目
Project NumberNational Natural Science Foundation of China [20525206, 20621091, 20772052] ; Ministry of Education of China
WOS IDWOS:000265419700002
Funding OrganizationNSFC ; MOE
SubtypeArticle
PMID 19206076
BIOSIS IDBIOSIS:PREV200900319212
Department
[Gong, Pin;
Chen, Fu Xin;
Zhao, Qianyu;
Ma, Guo Fen;
Wang, Rui] Lanzhou Univ, Sch Life Sci, Key Lab Preclinied Study New Drugs Gansu Prov, Sch Basic Med Sci,Inst Biochem & Mol Biol, Lanzhou 730000, Peoples R China;
[Gong, Pin;
Chen, Fu Xin;
Zhao, Qianyu;
Ma, Guo Fen;
Wang, Rui] Lanzhou Univ, State Key Lab Appl Organ Chem, Key Lab Preclinied Study New Drugs Gansu Prov, Sch Basic Med Sci,Inst Biochem & Mol Biol, Lanzhou 730000, Peoples R China...更多
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Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttps://ir.lzu.edu.cn/handle/262010/114692
Collection生命科学学院
基础医学院
Corresponding AuthorWang, R (reprint author), Lanzhou Univ, Sch Life Sci, Key Lab Preclinied Study New Drugs Gansu Prov, Sch Basic Med Sci,Inst Biochem & Mol Biol, Lanzhou 730000, Peoples R China.
Recommended Citation
GB/T 7714
Gong, P,Chen, FX,Zhao, QY,et al. The oxidation metabolites of endomorphin 1 and its fragments induced by free radicals[J]. JOURNAL OF PEPTIDE SCIENCE,2009,15(5):337-344.
APA Gong, P,Chen, FX,Zhao, QY,Ma, GF,Wang, R,&Wang, R .(2009).The oxidation metabolites of endomorphin 1 and its fragments induced by free radicals.JOURNAL OF PEPTIDE SCIENCE,15(5),337-344.
MLA Gong, P,et al."The oxidation metabolites of endomorphin 1 and its fragments induced by free radicals".JOURNAL OF PEPTIDE SCIENCE 15.5(2009):337-344.
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