兰州大学机构库 >生命科学学院
MicroRNA-155 Functions as an OncomiR in Breast Cancer by Targeting the Suppressor of Cytokine Signaling 1 Gene
Jiang, SA; Zhang, HW; Lu, MH; He, XH; Li, Y; Gu, H; Liu, MF; Wang, ED; Liu, MF (reprint author), Chinese Acad Sci, State Key Lab Mol Biol, Inst Biochem & Cell Biol, Shanghai Inst Biol Sci, 320 Yueyang Rd, Shanghai 200031, Peoples R China.
ESI NOTE2017-07-19;Highly Cited Papers
2010-04-15
Source PublicationCANCER RESEARCH
ISSN0008-5472
Volume70Issue:8Pages:3119-3127
AbstractMicroRNA-155 (miR-155) is overexpressed in many human cancers; however, the mechanisms by which miR-155 functions as a putative oncomiR are largely unknown. Here, we report that the tumor suppressor gene suppressor of cytokine signaling 1 (socs1) is an evolutionarily conserved target of miR-155 in breast cancer cells. We found that mir-155 expression is inversely correlated with socs1 expression in breast cancer cell lines as well as in a subset of primary breast tumors. We also identified a 24A-->G mutation in the miR-155 binding site of the SOCS1 3' untranslated region in a breast tumor that reduced miR-155 repression, implicating a mechanism for miRNA targets to avoid repression. Ectopic expression of miR-155 significantly promoted the proliferation of breast cancer cells, the formation of soft agar foci in vitro, and the development of tumors in nude mice. In breast cancer cells, RNA interference silencing of socs1 recapitulates the oncogenic effects of miR-155, whereas restoration of socs1 expression attenuates the protumorigenesis function of miR-155, suggesting that miR-155 exerts its oncogenic role by negatively regulating socs1. Overexpression of miR-155 in breast cancer cells leads to constitutive activation of signal transducer and activator of transcription 3 (STAT3) through the Janus-activated kinase (JAK) pathway, and stimulation of breast cancer cells by the inflammatory cytokines IFN-gamma and interleukin-6 (IL-6), lipopolysaccharide (LPS), and polyriboinosinic: polyribocytidylic acid [poly(I:C)] significantly upregulates mir-155 expression, suggesting that miR-155 may serve as a bridge between inflammation and cancer. Taken together, our study reveals that miR-155 is an oncomiR in breast cancer and that miR-155 may be a potential target in breast cancer therapy. Cancer Res; 70(8); 3119-27. (C) 2010 AACR.
Subject AreaOncology
PublisherAMER ASSOC CANCER RESEARCH
DOI10.1158/0008-5472.CAN-09-4250
Publication PlacePHILADELPHIA
Indexed BySCIE ; PubMed ; MEDLINE ; ESI
Language英语
First Inst
Funding Project国家自然科学基金项目 ; 国家重点基础研究发展计划以及国家重大科学研究计划(973计划)
Project NumberMinistry of Science and Technology of China [2005CB724603] ; National Natural Science Foundation of China [30770474, 90919016, 30970621] ; Chinese Academy of Sciences [KSCX1-YW-R-64, KSCX2-YW-R-096] ; Science and Technology Commission of Shanghai Municipality [06PJ14105]
WOS IDWOS:000278486100016
Funding OrganizationNSFC ; MOST
SubtypeArticle
PMID 20354188
Department
[Wang, En-Duo] Chinese Acad Sci, State Key Lab Mol Biol, Inst Biochem & Cell Biol, Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China;
[Jiang, Shuai;
Lu, Ming-Hua;
He, Xiao-Hong;
Liu, Mo-Fang] Chinese Acad Sci, Core Facil Noncoding RNA, Shanghai 200031, Peoples R China;
[Jiang, Shuai;
Gu, Hua;
Liu, Mo-Fang] Chinese Acad Sci, Ctr Cell Signaling, Inst Biochem & Cell Biol, Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China;
[Zhang, Hong-Wei] Fudan Univ, Zhongshan Hosp, Dept Gen Surg, Shanghai 200433, Peoples R China;
[He, Xiao-Hong] Lanzhou Univ, Coll Life Sci, Lanzhou 730000, Peoples R China...更多
Citation statistics
Cited Times:496[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttps://ir.lzu.edu.cn/handle/262010/114864
Collection生命科学学院
Corresponding AuthorLiu, MF (reprint author), Chinese Acad Sci, State Key Lab Mol Biol, Inst Biochem & Cell Biol, Shanghai Inst Biol Sci, 320 Yueyang Rd, Shanghai 200031, Peoples R China.
Recommended Citation
GB/T 7714
Jiang, SA,Zhang, HW,Lu, MH,et al. MicroRNA-155 Functions as an OncomiR in Breast Cancer by Targeting the Suppressor of Cytokine Signaling 1 Gene[J]. CANCER RESEARCH,2010,70(8):3119-3127.
APA Jiang, SA.,Zhang, HW.,Lu, MH.,He, XH.,Li, Y.,...&Liu, MF .(2010).MicroRNA-155 Functions as an OncomiR in Breast Cancer by Targeting the Suppressor of Cytokine Signaling 1 Gene.CANCER RESEARCH,70(8),3119-3127.
MLA Jiang, SA,et al."MicroRNA-155 Functions as an OncomiR in Breast Cancer by Targeting the Suppressor of Cytokine Signaling 1 Gene".CANCER RESEARCH 70.8(2010):3119-3127.
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