The yak genome and adaptation to life at high altitude

doi:10.1038/ng.2343

兰州大学机构库 >生命科学学院

	The yak genome and adaptation to life at high altitude
	Qiu, Q(邱强); Zhang, GJ; Ma, T; Qian, WB; Wang, JY; Ye, ZQ; Cao, CC; Hu, QJ; Kim, J; Larkin, DM; Auvil, L; Capitanu, B; Ma, J; Lewin, HA; Qian, XJ; Lang, YS...更多 Qiu, Q(邱强); Zhang, GJ; Ma, T; Qian, WB; Wang, JY; Ye, ZQ; Cao, CC; Hu, QJ; Kim, J; Larkin, DM; Auvil, L; Capitanu, B; Ma, J; Lewin, HA; Qian, XJ; Lang, YS; Zhou, R; Wang, LZ; Wang, K; Xia, JQ; Liao, SG; Pan, SK; Lu, X; Hou, HL; Wang, Y; Zang, XT; Yin, Y; Ma, H; Zhang, J; Wang, ZF(王召锋); Zhang, YM(张迎梅); Zhang, DW(张大伟); Yonezawa, T; Hasegawa, M; Zhong, Y; Liu, WB; Zhang, Y; Huang, ZY; Zhang, SX(张胜祥); Long, RJ(龙瑞军); Yang, HM; Wang, J; Lenstra, JA; Cooper, DN; Wu, Y(武一); Wang, J; Shi, P; Wang, J; Liu, JQ(刘建全); Liu, JQ (reprint author), Lanzhou Univ, Coll Life Sci, State Key Lab Grassland Agroecosyst, Lanzhou 730000, Peoples R China.收起
	2012-08
Source Publication	NATURE GENETICS
ISSN	1061-4036
Volume	44 Issue:8 Pages:946-+
Abstract	Domestic yaks (Bos grunniens) provide meat and other necessities for Tibetans living at high altitude on the Qinghai-Tibetan Plateau and in adjacent regions. Comparison between yak and the closely related low-altitude cattle (Bos taurus) is informative in studying animal adaptation to high altitude. Here, we present the draft genome sequence of a female domestic yak generated using Illumina-based technology at 65-fold coverage. Genomic comparisons between yak and cattle identify an expansion in yak of gene families related to sensory perception and energy metabolism, as well as an enrichment of protein domains involved in sensing the extracellular environment and hypoxic stress. Positively selected and rapidly evolving genes in the yak lineage are also found to be significantly enriched in functional categories and pathways related to hypoxia and nutrition metabolism. These findings may have important implications for understanding adaptation to high altitude in other animal species and for hypoxia-related diseases in humans.
Subject Area	Genetics & Heredity
Publisher	NATURE PUBLISHING GROUP
DOI	10.1038/ng.2343
Publication Place	NEW YORK
Indexed By	SCIE ; PubMed ; MEDLINE ; BIOSIS
Language	英语
First Inst	是
Funding Project	国家自然科学基金项目 ; 国家国际科技合作专项 ; 高等学校学科创新引智计划（111计划）
Project Number	Natural Science Foundation of China [30725004, 40972018] ; Ministry of Science and Technology of China [2010DFB63500] ; International Collaboration 111 Projects of China ; 985 and 211 Projects of Lanzhou University ; Shenzhen Municipal Government [ZYC200903240077A] ; Hundreds-Talent Program from the Chinese Academy of Sciences
WOS ID	WOS:000306854700023
Funding Organization	NSFC ; MOST ; MOE ; SAFEA ; LZU
Subtype	Article
PMID	22751099
BIOSIS ID	BIOSIS:PREV201200581654
Department	[Qiu, Qiang; Ma, Tao; Hu, Quanjun; Zhou, Ran; Wang, Lizhong; Wang, Kun; Lu, Xu; Ma, Hui; Zhang, Jian; Wang, Zhaofeng...更多 [Qiu, Qiang; Ma, Tao; Hu, Quanjun; Zhou, Ran; Wang, Lizhong; Wang, Kun; Lu, Xu; Ma, Hui; Zhang, Jian; Wang, Zhaofeng; Zhang, Yingmei; Zhang, Dawei; Zhang, Shengxiang; Long, Ruijun; Wu, Yi; Liu, Jianquan] Lanzhou Univ, Coll Life Sci, State Key Lab Grassland Agroecosyst, Lanzhou 730000, Peoples R China; [Zhang, Guojie; Qian, Wubin; Wang, Junyi; Cao, Changchang; Qian, Xiaoju; Lang, Yongshan; Xia, Jinquan; Liao, Shengguang; Pan, Shengkai; Hou, Haolong; Wang, Yan; Zang, Xuetao; Yin, Ye; Liu, Wenbin; Zhang, Yan; Huang, Zhiyong; Yang, Huanming; Wang, Jian; Wang, Jun; Wang, Jian] Beijing Genom Inst BGI Shenzhen, Shenzhen, Peoples R China; [Ye, Zhiqiang; Shi, Peng] Chinese Acad Sci, State Key Lab Genet Resources & Evolut, Inst Kunming Zool, Kunming, Peoples R China; [Ye, Zhiqiang] Chinese Acad Sci, Grad Sch, Beijing, Peoples R China; [Kim, Jaebum; Ma, Jian] Univ Illinois, Inst Genom Biol, Urbana, IL USA; [Kim, Jaebum] Konkuk Univ, Dept Anim Biotechnol, Seoul, South Korea; [Larkin, Denis M.] Aberystwyth Univ, Inst Biol Environm & Rural Sci, Aberystwyth, Ceredigion, Wales; [Auvil, Loretta; Capitanu, Boris] Univ Illinois, Natl Ctr Supercomp Applicat, Urbana, IL USA; [Ma, Jian] Univ Illinois, Dept Bioengn, Urbana, IL USA; [Lewin, Harris A.] Univ Calif Davis, Dept Ecol & Evolut, Davis, CA 95616 USA; [Yonezawa, Takahiro; Hasegawa, Masami; Zhong, Yang] Fudan Univ, Sch Life Sci, Shanghai 200433, Peoples R China; [Lenstra, Johannes A.] Univ Utrecht, Fac Vet Med, Utrecht, Netherlands; [Cooper, David N.] Cardiff Univ, Inst Med Genet, Sch Med, Cardiff, S Glam, Wales; [Wang, Jun] Univ Copenhagen, Dept Biol, Copenhagen, Denmark; [Liu, Jianquan] Sichuan Univ, Key Lab Bioresources & Ecoenvironm, Coll Life Sci, Chengdu 610064, Peoples R China收起
Citation statistics	Cited Times:485[WOS] [WOS Record] [Related Records in WOS]
Document Type	期刊论文
Identifier	https://ir.lzu.edu.cn/handle/262010/115204
Collection	生命科学学院草地农业科技学院
Corresponding Author	Liu, JQ (reprint author), Lanzhou Univ, Coll Life Sci, State Key Lab Grassland Agroecosyst, Lanzhou 730000, Peoples R China.
Recommended Citation GB/T 7714	Qiu, Q,Zhang, GJ,Ma, T,et al. The yak genome and adaptation to life at high altitude[J]. NATURE GENETICS,2012,44(8):946-+.
APA	Qiu, Q.,Zhang, GJ.,Ma, T.,Qian, WB.,Wang, JY.,...&Liu, JQ .(2012).The yak genome and adaptation to life at high altitude.NATURE GENETICS,44(8),946-+.
MLA	Qiu, Q,et al."The yak genome and adaptation to life at high altitude".NATURE GENETICS 44.8(2012):946-+.

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