兰州大学机构库 >信息科学与工程学院
A Longitudinal Study of Atrophy in Amnestic Mild Cognitive Impairment and Normal Aging Revealed by Cortical Thickness
Yao, Zhijun1; Hu, Bin1,3; Liang, Chuanjiang1; Zhao, Lina1; Jackson, Mike2
2012-11-02
Source PublicationPLoS One   Impact Factor & Quartile Of Published Year  The Latest Impact Factor & Quartile
ISSN1932-6203
Volume7Issue:11Pages:-
AbstractIn recent years, amnestic mild cognitive impairment (aMCI) has attracted significant attention as an indicator of high risk for Alzheimer's disease. An understanding of the pathology of aMCI may benefit the development of effective clinical treatments for dementia. In this work, we measured the cortical thickness of 109 aMCI subjects and 99 normal controls (NC) twice over two years. The longitudinal changes and the cross-sectional differences between the two types of participants were explored using the vertex thickness values. The thickness of the cortex in aMCI was found significantly reduced in both longitudinal and between-group comparisons, mainly in the temporal lobe, superolateral parietal lobe and some regions of the frontal cortices. Compared to NC, the aMCI showed a significantly high atrophy rate in the left lateral temporal lobe and left parahippocampal gyrus over two years. Additionally, a significant positive correlation between brain atrophy and the decline of Mini-Mental State Examination (MMSE) scores was also found in the left superior and left middle temporal gyrus in aMCI. These findings demonstrated specific longitudinal spatial patterns of cortical atrophy in aMCI and NC. The higher atrophy rate in aMCI might be responsible for the accelerated functional decline in the aMCI progression process.
Subject AreaScience & Technology - Other Topics
PublisherPLOS
DOI10.1371/journal.pone.0048973
Publication PlaceSAN FRANCISCO
Indexed BySCIE ; PubMed ; MEDLINE ; BIOSIS
Language英语
First Inst
Funding Project国家自然科学基金项目 ; 国家重点基础研究发展计划以及国家重大科学研究计划(973计划) ; 中央高校基本科研业务费专项资金 ; 美国国立卫生研究院项目
Project NumberNational Basic Research Program of China (973 Program) [2011CB711000] ; National Natural Science Foundation of China [60973138, 61003240] ; EU's Seventh Framework Programme OPTIMI [248544] ; Study of Brain Network of The Group of Mild Cognitive Impairment [Lzujbky-2011-61] ; Alzheimer's Disease Neuroimaging Initiative (ADNI) (National Institutes of Health) [U01 AG024904] ; National Institutes of Health [P30 AG010129, K01 AG030514] ; Dana Foundation
WOS IDWOS:000310702400051
Funding OrganizationNSFC ; MOST ; LZU ; NIH
SubtypeArticle
PMID 23133666
BIOSIS IDBIOSIS:PREV201300037099
Department[Yao, Zhijun;
Hu, Bin;
Liang, Chuanjiang;
Zhao, Lina] Lanzhou Univ, Sch Informat Sci & Engn, Lanzhou 730000, Peoples R China;
[Jackson, Mike] Birmingham City Univ, Birmingham City Business Sch, Birmingham, W Midlands, England;
[Hu, Bin] Birmingham City Univ, Sch Comp Telecomminicat & Networks, Birmingham, W Midlands, England
Citation statistics
Document Type期刊论文
Identifierhttps://ir.lzu.edu.cn/handle/262010/116220
Collection信息科学与工程学院
Corresponding AuthorHu, Bin
Affiliation
1.Lanzhou Univ, Sch Informat Sci & Engn, Lanzhou 730000, Peoples R China
2.Birmingham City Univ, Birmingham City Business Sch, Birmingham, W Midlands, England
3.Birmingham City Univ, Sch Comp Telecomminicat & Networks, Birmingham, W Midlands, England
Recommended Citation
GB/T 7714
Yao, Zhijun,Hu, Bin,Liang, Chuanjiang,et al. A Longitudinal Study of Atrophy in Amnestic Mild Cognitive Impairment and Normal Aging Revealed by Cortical Thickness[J]. PLoS One,2012,7(11):-.
APA Yao, Zhijun,Hu, Bin,Liang, Chuanjiang,Zhao, Lina,&Jackson, Mike.(2012).A Longitudinal Study of Atrophy in Amnestic Mild Cognitive Impairment and Normal Aging Revealed by Cortical Thickness.PLoS One,7(11),-.
MLA Yao, Zhijun,et al."A Longitudinal Study of Atrophy in Amnestic Mild Cognitive Impairment and Normal Aging Revealed by Cortical Thickness".PLoS One 7.11(2012):-.
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