兰州大学机构库 >核科学与技术学院
Investigation of the limitations of the highly pixilated CdZnTe detector for PET applications
Komarov, Sergey1; Yin, Yongzhi2; Wu, Heyu1; Wen, Jie3; Krawczynski, Henric4; Meng, Ling-Jian5; Tai, Yuan-Chuan1
2012-11-21
Source PublicationPHYSICS IN MEDICINE AND BIOLOGY   Impact Factor & Quartile Of Published Year  The Latest Impact Factor & Quartile
ISSN0031-9155
Volume57Issue:22Pages:7355-7380
AbstractWe are investigating the feasibility of a high resolution positron emission tomography (PET) insert device based on the CdZnTe detector with 350 mu m anode pixel pitch to be integrated into a conventional animal PET scanner to improve its image resolution. In this paper, we have used a simplified version of the multi pixel CdZnTe planar detector, 5 mm thick with 9 anode pixels only. This simplified 9 anode pixel structure makes it possible to carry out experiments without a complete application-specific integrated circuits readout system that is still under development. Special attention was paid to the double pixel (or charge sharing) detections. The following characteristics were obtained in experiment: energy resolution full-width-at-half-maximum (FWHM) is 7% for single pixel and 9% for double pixel photoelectric detections of 511 keV gammas; timing resolution (FWHM) from the anode signals is 30 ns for single pixel and 35 ns for double pixel detections (for photoelectric interactions only the corresponding values are 20 and 25 ns); position resolution is 350 mu m in x,y-plane and similar to 0.4 mm in depth-of-interaction. The experimental measurements were accompanied by Monte Carlo (MC) simulations to find a limitation imposed by spatial charge distribution. Results from MC simulations suggest the limitation of the intrinsic spatial resolution of the CdZnTe detector for 511 keV photoelectric interactions is 170 mu m. The interpixel interpolation cannot recover the resolution beyond the limit mentioned above for photoelectric interactions. However, it is possible to achieve higher spatial resolution using interpolation for Compton scattered events. Energy and timing resolution of the proposed 350 mu m anode pixel pitch detector is no better than 0.6% FWHM at 511 keV, and 2 ns FWHM, respectively. These MC results should be used as a guide to understand the performance limits of the pixelated CdZnTe detector due to the underlying detection processes, with the understanding of the inherent limitations of MC methods.
Subject AreaEngineering ; Radiology, Nuclear Medicine & Medical Imaging
PublisherIOP
DOI10.1088/0031-9155/57/22/7355
Publication PlaceBRISTOL
Indexed BySCIE ; EI
Language英语
First Inst
Funding Project美国能源部项目
Project NumberOffice of Science (BER), U.S. Department of Energy [DE-FG02-08ER64681]
WOS IDWOS:000310838700013
Funding OrganizationUS DOE
SubtypeArticle
EI ID20124715685160
Department[Komarov, Sergey;
Wu, Heyu;
Tai, Yuan-Chuan] Washington Univ, Dept Radiol, St Louis, MO 63110 USA;
[Yin, Yongzhi] Lanzhou Univ, Sch Nucl Sci & Technol, Lanzhou 73000, Gansu, Peoples R China;
[Wen, Jie] Washington Univ, Dept Elect & Syst Engn, St Louis, MO 63110 USA;
[Krawczynski, Henric] Washington Univ, Dept Phys, St Louis, MO 63110 USA;
[Meng, Ling-Jian] Univ Illinois, Dept Nucl Plasma & Radiol Engn, Urbana, IL 61822 USA
Citation statistics
Document Type期刊论文
Identifierhttps://ir.lzu.edu.cn/handle/262010/117193
Collection核科学与技术学院
Corresponding AuthorKomarov, Sergey
Affiliation
1.Washington Univ, Dept Radiol, St Louis, MO 63110 USA
2.Lanzhou Univ, Sch Nucl Sci & Technol, Lanzhou 73000, Gansu, Peoples R China
3.Washington Univ, Dept Elect & Syst Engn, St Louis, MO 63110 USA
4.Washington Univ, Dept Phys, St Louis, MO 63110 USA
5.Univ Illinois, Dept Nucl Plasma & Radiol Engn, Urbana, IL 61822 USA
Recommended Citation
GB/T 7714
Komarov, Sergey,Yin, Yongzhi,Wu, Heyu,et al. Investigation of the limitations of the highly pixilated CdZnTe detector for PET applications[J]. PHYSICS IN MEDICINE AND BIOLOGY,2012,57(22):7355-7380.
APA Komarov, Sergey.,Yin, Yongzhi.,Wu, Heyu.,Wen, Jie.,Krawczynski, Henric.,...&Tai, Yuan-Chuan.(2012).Investigation of the limitations of the highly pixilated CdZnTe detector for PET applications.PHYSICS IN MEDICINE AND BIOLOGY,57(22),7355-7380.
MLA Komarov, Sergey,et al."Investigation of the limitations of the highly pixilated CdZnTe detector for PET applications".PHYSICS IN MEDICINE AND BIOLOGY 57.22(2012):7355-7380.
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