兰州大学机构库 >基础医学院
Endomorphin 1 effectively protects cadmium chloride-induced hepatic damage in mice
Gong, P; Chen, FX; Ma, GF; Feng, Y; Zhao, QY; Wang, R(王锐); Wang, R (reprint author), Lanzhou Univ, Key Lab Preclinied Study New Drugs Gansu Prov, Sch Basic Med Sci, Inst Biochem & Mol Biol, Lanzhou 730000, Peoples R China.
2008-09-29
Source PublicationTOXICOLOGY   Impact Factor & Quartile
ISSN0300-483X
Volume251Issue:1-3Pages:35-44
AbstractThe antioxidative capacity of endomorphin 1 (EM1), an endogenous mu-opioid receptor agonist, has been demonstrated by in vivo assays. The present study reports the effect of EM1 on hepatic damage induced by cadmium chloride (Cd(II)) in adult male mouse. Mouse were given intraperitoneally (i.p.) a single dose of Cd(II) (1 mg/kg body weight per day) and the animals were co-administrated with a dose of EM1 (50 mu M/kg body weight per day) for 6 days. Since hepatic damage induced by Cd(II) is related to oxidative stress, lipid peroxidation (LPO), protein carbonyl (PCO), superoxide dismutase (SOD), catalase (CAT) and reduced glutathione (GSH) were evaluated. The parameter indicating tissue damage such as liver histopathology was also determined. In addition, the concentrations of Cd and zinc (Zn) in the liver were analyzed. The intoxication of Cd(II) lead to the enhanced production of LPO and PCO, treatment with EM1 can effectively ameliorate the increase of LPO and PCO compared to the Cd(II) group. The increased activities of CAT, SOD and the elevated GSH induced by Cd(II) may relate to an adaptive-response to the oxidative damage, the effect of EM1 can restore the elevated antioxidant defense. Our results suggested that the structure features and the ability of chelating metal of EM1 may play a major role in the antioxidant effect of EM1 in vivo and opioid receptors may be involved in the protection of hepatic damage induced by Cd(II). (C) 2008 Elsevier Ireland Ltd. All rights reserved.
KeywordEndomorphin 1 Cadmium Oxidative damage Antioxidant
Subject AreaPharmacology & Pharmacy ; Toxicology
PublisherELSEVIER
DOI10.1016/j.tox.2008.07.051
Publication PlaceCLARE
Indexed BySCIE ; PubMed ; MEDLINE ; BIOSIS
Language英语
First Inst
Funding Project国家自然科学基金项目
Project NumberNational Natural Science Foundation of China [20525206, 20621091, 20772052] ; Ministry of Education of China
WOS IDWOS:000260367000005
Funding OrganizationNSFC ; MOE
SubtypeArticle
PMID 18703112
BIOSIS IDBIOSIS:PREV200800705280
Department
[Gong, Pin;
Chen, Fu Xin;
Ma, Guo Fen;
Feng, Yun;
Zhao, QianYu;
Wang, Rui] Lanzhou Univ, Key Lab Preclinied Study New Drugs Gansu Prov, Sch Basic Med Sci, Inst Biochem & Mol Biol, Lanzhou 730000, Peoples R China;
[Gong, Pin;
Chen, Fu Xin;
Ma, Guo Fen;
Feng, Yun...更多
Citation statistics
Cited Times:30[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttps://ir.lzu.edu.cn/handle/262010/121391
Collection基础医学院
Corresponding AuthorWang, R (reprint author), Lanzhou Univ, Key Lab Preclinied Study New Drugs Gansu Prov, Sch Basic Med Sci, Inst Biochem & Mol Biol, Lanzhou 730000, Peoples R China.
Recommended Citation
GB/T 7714
Gong, P,Chen, FX,Ma, GF,et al. Endomorphin 1 effectively protects cadmium chloride-induced hepatic damage in mice[J]. TOXICOLOGY,2008,251(1-3):35-44.
APA Gong, P.,Chen, FX.,Ma, GF.,Feng, Y.,Zhao, QY.,...&Wang, R .(2008).Endomorphin 1 effectively protects cadmium chloride-induced hepatic damage in mice.TOXICOLOGY,251(1-3),35-44.
MLA Gong, P,et al."Endomorphin 1 effectively protects cadmium chloride-induced hepatic damage in mice".TOXICOLOGY 251.1-3(2008):35-44.
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