兰州大学机构库 >基础医学院
Membrane-Active Action Mode of Polybia-CP, a Novel Antimicrobial Peptide Isolated from the Venom of Polybia paulista
Wang, Kairong; Yan, Jiexi; Chen, Ru; Dang, Wen; Zhang, Bangzhi; Zhang, Wei; Song, Jingjing; Wang, Rui
2012-06
Source PublicationANTIMICROBIAL AGENTS AND CHEMOTHERAPY   Impact Factor & Quartile Of Published Year  The Latest Impact Factor & Quartile
ISSN0066-4804
Volume56Issue:6Pages:3318-3323
AbstractThe extensive use of antibiotics in medicine, the food industry, and agriculture has resulted in the frequent emergence of multidrug-resistant bacteria, which creates an urgent need for new antibiotics. it is now widely recognized that antimicrobial peptides (AMPs) could play a promising role in fighting multidrug-resistant bacteria. Antimicrobial peptide polybia-CP was purified from the venom of the social wasp Polybia paulista. In this study, we synthesized polybia-CP and studied its action mode of antibacterial activity. Our results revealed that polybia-CP has potent antibacterial activity against both Gram-positive and Gram-negative bacteria. The results from both the real bacterial membrane and the in vitro model membrane showed that polybia-CP is membrane active and that its action target is the membrane of bacteria. It is difficult for bacteria to develop resistance to polybia-CP, which may thus offer a new strategy for defending against resistant bacteria in medicine and the food and farming industries.
Subject AreaMicrobiology ; Pharmacology & Pharmacy
PublisherAMER SOC MICROBIOLOGY
DOI10.1128/AAC.05995-11
Publication PlaceWASHINGTON
Indexed BySCIE ; PubMed ; MEDLINE ; BIOSIS
Language英语
First Inst
Funding Project国家自然科学基金项目 ; 国家科技重大专项 ; 春晖计划 ; 中央高校基本科研业务费专项资金
Project NumberNational Natural Science Foundation of China [90813012, 20932003] ; Ministry of Science and Technology [2012ZX09504001-003] ; Ministry of Education of China [2010082] ; Fundamental Research Funds for the Central Universities [lzujbky-2010-129]
WOS IDWOS:000304432800069
Funding OrganizationNSFC ; MOST ; MOE ; LZU
SubtypeArticle
PMID 22450985
BIOSIS IDBIOSIS:PREV201200453278
Department[Wang, Kairong;
Yan, Jiexi;
Chen, Ru;
Dang, Wen;
Zhang, Bangzhi;
Zhang, Wei;
Song, Jingjing;
Wang, Rui] Lanzhou Univ, Key Lab Preclin Study New Drugs Gansu Prov, Sch Basic Med Sci, Sch Life Sci,Inst Biochem & Mol Biol, Lanzhou 730000, Peoples R China
Citation statistics
Document Type期刊论文
Identifierhttps://ir.lzu.edu.cn/handle/262010/121551
Collection基础医学院
生命科学学院
Corresponding AuthorWang, Rui
Affiliation
Lanzhou Univ, Key Lab Preclin Study New Drugs Gansu Prov, Sch Basic Med Sci, Sch Life Sci,Inst Biochem & Mol Biol, Lanzhou 730000, Peoples R China
First Author AffilicationSchool of Life Sciences
Corresponding Author AffilicationSchool of Life Sciences
First Signature AffilicationSchool of Life Sciences
Recommended Citation
GB/T 7714
Wang, Kairong,Yan, Jiexi,Chen, Ru,et al. Membrane-Active Action Mode of Polybia-CP, a Novel Antimicrobial Peptide Isolated from the Venom of Polybia paulista[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY,2012,56(6):3318-3323.
APA Wang, Kairong.,Yan, Jiexi.,Chen, Ru.,Dang, Wen.,Zhang, Bangzhi.,...&Wang, Rui.(2012).Membrane-Active Action Mode of Polybia-CP, a Novel Antimicrobial Peptide Isolated from the Venom of Polybia paulista.ANTIMICROBIAL AGENTS AND CHEMOTHERAPY,56(6),3318-3323.
MLA Wang, Kairong,et al."Membrane-Active Action Mode of Polybia-CP, a Novel Antimicrobial Peptide Isolated from the Venom of Polybia paulista".ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 56.6(2012):3318-3323.
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