兰州大学机构库 >基础医学院
Hypoxia-inducible Factor 1 Alpha (HIF-1 alpha) as a Prognostic Indicator in Patients with Gastric Tumors: A Meta-analysis
Zhang, ZG; Zhang, QN; Wang, XH; Tian, JH(田金徽); Wang, XH (reprint author), Lanzhou Univ, Evidence Based Med Ctr, Lanzhou 730000, Peoples R China.
2013
Source PublicationASIAN PAC J CANCER P   Impact Factor & Quartile
ISSN1513-7368
Volume14Issue:7Pages:4195-4198
AbstractBackground and Objective: Though researched for years, the prognostic role of hypoxia-inducible factor 1 alpha (HIF-1 alpha) in gastric cancer is still controversial. We thus undertook a systematic review to assess the relationship. Method: A systematically literature search of Pubmed, Embase, Web of Science, China Biological Medicine Disc and Cochrane Library was undertaken in February 2013, and the reference lists of articles were retrieved. Results: 12 trials (1,555 participants) were included to assess the association between HIF-1 alpha expression and survival. Summary hazard ratios (HRs) were calculated. HIF-1 alpha expression was significantly correlated with poor overall survival of gastric cancer patients (HR=1.34, 95% CI: 1.13-1.58; P=0.0009), but not with poor disease free survival of gastric cancer patients (HR=1.67, 95% CI: 0.99-2.82; P=0.06). Conclusion: HIF-1 alpha was associated with poor OS, but not DFS, especially for Asian patients. But studies evaluating relationships of HIF-1 alpha with OS and DFS in non-Asian gastric cancer patients appear needed.
KeywordStomach neoplasm Hypoxia-inducible factor survival meta-analysis
Subject AreaOncology
PublisherASIAN PACIFIC ORGANIZATION CANCER PREVENTION
DOI10.7314/APJCP.2013.14.7.4195
Publication PlaceGYEONGGI-DO
Indexed BySCIE ; PubMed ; MEDLINE
Language英语
First Inst
WOS IDWOS:000328269400032
SubtypeArticle
PMID 23991975
Department[Zhang, Zhi-Gang;
Wang, Xiao-Hu;
Tian, Jin-Hui] Lanzhou Univ, Evidence Based Med Ctr, Lanzhou 730000, Peoples R China;
[Zhang, Zhi-Gang;
Zhang, Qiu-Ning;
Wang, Xiao-Hu;
Tian, Jin-Hui] Lanzhou Univ, Clin Med Coll 1, Lanzhou 730000, Peoples R China;
[Zhang, Qiu-Ning;
Wang, Xiao-Hu] Gansu Prov Tumor Hosp, Dept Radiat Oncol, Lanzhou, Peoples R China
Citation statistics
Cited Times:19[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttps://ir.lzu.edu.cn/handle/262010/121660
Collection基础医学院
Corresponding AuthorWang, XH (reprint author), Lanzhou Univ, Evidence Based Med Ctr, Lanzhou 730000, Peoples R China.
Recommended Citation
GB/T 7714
Zhang, ZG,Zhang, QN,Wang, XH,et al. Hypoxia-inducible Factor 1 Alpha (HIF-1 alpha) as a Prognostic Indicator in Patients with Gastric Tumors: A Meta-analysis[J]. ASIAN PAC J CANCER P,2013,14(7):4195-4198.
APA Zhang, ZG,Zhang, QN,Wang, XH,Tian, JH,&Wang, XH .(2013).Hypoxia-inducible Factor 1 Alpha (HIF-1 alpha) as a Prognostic Indicator in Patients with Gastric Tumors: A Meta-analysis.ASIAN PAC J CANCER P,14(7),4195-4198.
MLA Zhang, ZG,et al."Hypoxia-inducible Factor 1 Alpha (HIF-1 alpha) as a Prognostic Indicator in Patients with Gastric Tumors: A Meta-analysis".ASIAN PAC J CANCER P 14.7(2013):4195-4198.
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