兰州大学机构库 >基础医学院
Dual antifungal properties of cationic antimicrobial peptides polybia-MPI: Membrane integrity disruption and inhibition of biofilm formation
Wang, KR; Yan, JX; Dang, W; Xie, JQ; Yan, B; Yan, WJ; Sun, MY; Zhang, BZ(张邦治); Ma, MX; Zhao, YY; Jia, FJ; Zhu, RR; Chen, W; Wang, R(王锐); Wang, R (reprint author), Lanzhou Univ, Sch Basic Med Sci, Key Lab Preclin Study New Drugs Gansu Prov, 222 Tian Shui South Rd, Lanzhou 730000, Peoples R China.
2014-06
Source PublicationPEPTIDES   Impact Factor & Quartile
ISSN0196-9781
Volume56Pages:22-29
AbstractWith the increasing emergence of resistant fungi, the discovery and development of novel antifungal therapeutics were urgently needed. Compared with conventional antibiotics, the limited propensity of AMPs to induce resistance in pathogens has attracted great interest. In the present study, the antifungal activity and its mechanism-of-action of polybia-MPI, a cationic peptide from the venom of Social wasp Poly bia Paulista was investigated. We demonstrated that polybia-MPI could potently inhibit the growth of Candida albi cans (C. albicans) and Candida glabrata (C. glabrata). The 50% inhibitory concentrations (IC50) of Polybia-MPI against cancer cells were much higher than the MICs against the tested C. albi cans and C. glabrata cells, indicating that polybia-MPI had high selectivity between the fungal and mammalian cells. Our results also indicated that membrane disturbance mechanism was involved in the antifungal activity. Furthermore, polybia-MPI could inhibit the bio film forming of C. glabrata, which was frequently associated with clinically significant biofilm. These results suggest that polybia-MPI has great advantages in the development of antifungal agents. 2014 Elsevier Inc. All rights reserved.
KeywordAntifungal activity Antimicrobial peptide Polybia-MPI Biofilm formation
Subject AreaBiochemistry & Molecular Biology ; Pharmacology & Pharmacy
PublisherELSEVIER
DOI10.1016/j.peptides.2014.03.005
Publication PlaceNEW YORK
Indexed BySCIE ; PubMed ; MEDLINE ; BIOSIS
Language英语
First Inst
Funding Project国家自然科学基金项目 ; 国家科技重大专项 ; 高等学校博士学科点专项科研基金 ; 中央高校基本科研业务费专项资金
Project NumberNational Natural Science Foundation of China [91213302, 21272102, 31200584, 21272108] ; Key National S&T Program "Major New Drug Development" of the Ministry of Science and Technology [2012ZX09504001-003] ; Research Fund for the Doctoral Program of Higher Education of China [20120211120045] ; Fundamental Research Funds for the Central Universities [lzujbky-2013-164, lzujbky-2013-168]
WOS IDWOS:000336521500004
Funding OrganizationNSFC ; MOST ; MOE ; LZU
SubtypeArticle
PMID 24642357
BIOSIS IDBIOSIS:PREV201400486522
Department
[Wang, Kairong;
Yan, Jiexi;
Dang, Wen;
Xie, Junqiu;
Yan, Bo;
Yan, Wenjin;
Sun, Mengyang;
Zhang, Bangzhi;
Ma, Mingxia;
Zhao, Yanyan...更多
Citation statistics
Cited Times:50[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttps://ir.lzu.edu.cn/handle/262010/121696
Collection基础医学院
Corresponding AuthorWang, R (reprint author), Lanzhou Univ, Sch Basic Med Sci, Key Lab Preclin Study New Drugs Gansu Prov, 222 Tian Shui South Rd, Lanzhou 730000, Peoples R China.
Recommended Citation
GB/T 7714
Wang, KR,Yan, JX,Dang, W,et al. Dual antifungal properties of cationic antimicrobial peptides polybia-MPI: Membrane integrity disruption and inhibition of biofilm formation[J]. PEPTIDES,2014,56:22-29.
APA Wang, KR.,Yan, JX.,Dang, W.,Xie, JQ.,Yan, B.,...&Wang, R .(2014).Dual antifungal properties of cationic antimicrobial peptides polybia-MPI: Membrane integrity disruption and inhibition of biofilm formation.PEPTIDES,56,22-29.
MLA Wang, KR,et al."Dual antifungal properties of cationic antimicrobial peptides polybia-MPI: Membrane integrity disruption and inhibition of biofilm formation".PEPTIDES 56(2014):22-29.
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